Patents by Inventor James R. Hauske

James R. Hauske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic analgesic compounds and methods of use thereof
    Publication number: 20020016337
    Abstract: One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-coupled receptors, and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds as analgesics.
    Type: Application
    Filed: March 2, 2001
    Publication date: February 7, 2002
    Inventors: Gregory D. Cuny, Liming Shao, James R. Hauske, Michele L.R. Heffernan, Brian M. Aquila, Xinhe Wu, Fengjiang Wang, Thomas D. Bannister
  • 3-substituted piperidines comprising urea functionality, and methods of use thereof
    Publication number: 20010056090
    Abstract: One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various cellular receptors, including opioid receptors, other G-protein-coupled receptors and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as analgesics.
    Type: Application
    Filed: February 23, 2001
    Publication date: December 27, 2001
    Inventors: Brian M. Aquila, Gregory D. Cuny, James R. Hauske, Liming Shao, Xinhe Wu
  • Ring opening metathesis of alkenes
    Publication number: 20010034341
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Application
    Filed: January 23, 2001
    Publication date: October 25, 2001
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske
  • Antimicrobial agents uses and compositions related thereto
    Patent number: 6207679
    Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: March 27, 2001
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi
  • Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
    Patent number: 6180640
    Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: January 30, 2001
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, James R. Hauske, Michael Z. Hoemann, Richard F. Rossi, Roger L. Xie
  • Ring opening metathesis of alkenes
    Patent number: 6177464
    Abstract: Methods for performing ring-opening cross-metathesis reactions on solid support are disclosed. Substituted cyclic compounds, libraries of the compounds, and methods of using the compounds to treat bacterial infections are also disclosed.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: January 23, 2001
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, Jingrong Cao, James R. Hauske
  • Quinoline-indole antimicrobial agents, uses and compositions related thereto
    Patent number: 6172084
    Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 9, 2001
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi
  • Quinoline-indole antimicrobial agents, uses and compositions related thereto
    Patent number: 6103905
    Abstract: The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacteria microorganisms. Additionally, the present invention provides methods and pharmaceutical preparations that kill bacterial microorganisms.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: August 15, 2000
    Assignee: Sepracor, Inc.
    Inventors: Gregory D. Cuny, James R. Hauske, Donald L. Heefner, Michael Z. Hoemann, Gnanasambandam Kumaravel, Anita Melikian-Badalian, Richard F. Rossi, Roger L. Xie
  • Desosamino derivatives of macrolides
    Patent number: 5563135
    Abstract: Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and auto-immune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), ##STR1## wherein n is 1 or 2; A and B are taken together and form .dbd.O or A and B are taken separately and are each H or A is OH and B is H; R.sup.1 is a desosamino group; R.sup.2 is OH or a desosaminyloxy group; and R.sup.3 is an alkyl or allyl group.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 8, 1996
    Assignee: Pfizer Inc.
    Inventors: James R. Hauske, Gary R. Schulte
  • Desosamino derivatives of macrolides as immunosuppressants and antifungal agents
    Patent number: 5506233
    Abstract: Macrolides of the FK-506 type and methods of treatment of resistance to transplantation, fungal infections, and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: April 9, 1996
    Assignee: Pfizer Inc.
    Inventors: James R. Hauske, Gary R. Schulte
  • Phosponated derivatives of macrolides
    Patent number: 5359060
    Abstract: Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), ##STR1## wherein n is 1 or 2; A and B taken together form .dbd.O or A and B taken separately are each H or A is OH and B is H; R.sup.1 is a group of the formula ##STR2## R.sup.2 is OH or a desosaminyloxy group; and R.sup.3 is an alkyl or allyl group.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: October 25, 1994
    Assignee: Pfizer, Inc.
    Inventor: James R. Hauske
  • Acid polycyclic ether antibiotic
    Patent number: 5064855
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: January 28, 1991
    Date of Patent: November 12, 1991
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Gloria J. Kostek, Hiroshi Maeda, Junsuke Tone
  • Process for preparing macrolide antibiotics by culturing streptomyces hirsutus ATCC 53513
    Patent number: 4956283
    Abstract: An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: September 11, 1990
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Hiroshi Maeda, Junsuke Tone
  • Acidic polycyclic ether antibiotic
    Patent number: 4920050
    Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: April 24, 1990
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Gloria J. Kostek, Hiroshi Maeda, Junsuke Tone
  • C.12 modified erythromycin A derivatives
    Patent number: 4857641
    Abstract: Antibacterial 12,12'-anhydro-9R-hydroxy-9-deoxoerythromycin A derivatives, intermediate therefor and process of 12,12'-dehydration.
    Type: Grant
    Filed: August 14, 1987
    Date of Patent: August 15, 1989
    Assignee: Pfizer Inc.
    Inventor: James R. Hauske
  • Neutral macrolide antibiotics from Streptomyces
    Patent number: 4835141
    Abstract: An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.
    Type: Grant
    Filed: December 5, 1986
    Date of Patent: May 30, 1989
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, James R. Hauske, Hiroshi Maeda, Junsuke Tone
  • 9.alpha.-Aza-9.alpha.-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
    Patent number: 4518590
    Abstract: Certain novel 9-deoxo-4"-deoxy-4"-amino-9a-aza-9a-homoerythromycin A derivatives; a method of treating a bacterial infection in a mammalian subject using the novel erythromycin A derivatives; pharmaceutical compositions containing the novel erythromycin A derivatives; and intermediates and processes for making the novel erythromycin A derivatives.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: May 21, 1985
    Assignee: Pfizer Inc.
    Inventors: James R. Hauske, Arthur A. Nagel
  • 9.alpha.-Aza-9.alpha.-homoerythromycin compounds, pharmaceutical composition and therapeutic method
    Patent number: 4512982
    Abstract: Certain novel 9-deoxo-4"-deoxy-4"-amino-9a-aza-9a-homoerythromycin A derivatives; a method of treating a bacterial infection in a mammalian subject using these novel erythromycin A derivatives; pharmaceutical compositions containing the novel erythromycin A derivatives; and intermediates and processes for making the novel erythromycin A derivatives.
    Type: Grant
    Filed: April 13, 1984
    Date of Patent: April 23, 1985
    Assignee: Pfizer Inc.
    Inventors: James R. Hauske, Arthur A. Nagel
  • Azahomoerythromycin D derivative and intermediates therefor
    Patent number: 4465674
    Abstract: Antibacterial 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin D, pharmaceutically-acceptable salts thereof, pharmaceutical compositions comprising antibacterially-effective amounts thereof, a method of treatment of bacterial infections with antibacterially effective amounts thereof, and intermediates for the synthesis thereof from erythromycin D.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: August 14, 1984
    Assignee: Pfizer Inc.
    Inventors: Gene M. Bright, James R. Hauske
  • Semi-synthetic macrolides
    Patent number: 4413119
    Abstract: The reaction product of dimethyl diazomethylphosphonate with 4"-deoxy-4"-oxo-oleandomycin and erythromycin A derivatives as antibacterial agents, and intermediates leading thereto.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: November 1, 1983
    Assignee: Pfizer Inc.
    Inventor: James R. Hauske