Patents by Inventor James R. Millis

James R. Millis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHYLENEMALONIC ACID AND INTERMEDIATES, PROCESSES FOR THEIR PREPARATION AND ENGINEERED MICROORGANISMS
    Publication number: 20190169657
    Abstract: The description relates to, inter alia, recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include methylenemalonic acid and intermediates, as well as their salts and esters.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 6, 2019
    Inventors: MAN KIT LAU, CATHY STALOCH HASS, JAMES R. MILLIS
  • BIOBASED PRODUCTION OF FUNCTIONALIZED ALPHA-SUBSTITUTED ACRYLATES AND C4-DICARBOXYLATES
    Publication number: 20180179499
    Abstract: The description provides, inter alia, recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include functionalized alpha substituted C4 dicarboxylic acids and functionalized acrylic acids and salts, esters and lactones thereof.
    Type: Application
    Filed: June 3, 2016
    Publication date: June 28, 2018
    Inventors: Man Kit LAU, Cathy Staloch HASS, Hayat Nuru AHMED, Ralph Thomas BAKER, James R. MILLIS, Indira THAPA
  • PRODUCTION OF ISOPRENOIDS
    Publication number: 20150299732
    Abstract: A recombinant yeast that makes an isoprenoid compound is provided. The yeast comprises an endogenous mevalonate pathway comprising (i) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (ii) an enzyme that converts acetoacetyl-CoA to hydroxymethylglutaryl-CoA, (iii) an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, (iv) an enzyme that converts mevalonic acid to phosphomevalonic acid, (v) an enzyme that converts phosphomevalonic acid to phosphomevalonate, and (vi) an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. The yeast further comprises heterologous nucleic acid sequences encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, an enzyme that converts mevalonic acid to phosphomevalonic acid, an enzyme that converts phosphomevalonic acid to phosphomevalonate, and an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • ALTERNATIVE PATHWAYS TO ADIPIC ACID BY COMBINED FERMENTATION AND CATALYTIC METHODS
    Publication number: 20150225329
    Abstract: Processes process for producing adipate or adipic acid using biological pathways and chemical catalyzes are disclosed. Homocitric acid may be a substrate in reaction pathways leading to adipic acid or a salt thereof.
    Type: Application
    Filed: September 11, 2013
    Publication date: August 13, 2015
    Inventors: James R. Millis, Man Kit Lau
  • Production of isoprenoids
    Patent number: 9102954
    Abstract: A recombinant yeast that makes an isoprenoid compound is provided. The yeast comprises an endogenous mevalonate pathway comprising (i) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (ii) an enzyme that converts acetoacetyl-CoA to hydroxymethylglutaryl-CoA, (iii) an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, (iv) an enzyme that converts mevalonic acid to phosphomevalonic acid, (v) an enzyme that converts phosphomevalonic acid to phosphomevalonate, and (vi) an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. The yeast further comprises heterologous nucleic acid sequences encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, an enzyme that converts mevalonic acid to phosphomevalonic acid, an enzyme that converts phosphomevalonic acid to phosphomevalonate, and an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 11, 2015
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 9034610
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: May 19, 2015
    Assignee: CARGILL, INCORPORATED
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, James R. Millis, John Rosazza, David P. Weiner, Lishan Zhao
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 8435765
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: May 7, 2013
    Assignee: Cargill, Incorporated
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, James R. Millis, John Rosazza, David P. Weiner, Lishan Zhao
  • BIOBASED COMPOSITIONS OF DIAMMONIUM SUCCINATE, MONOAMMONIUM SUCCINATE AND/OR SUCCINIC ACID AND DERIVATIVES THEREOF
    Publication number: 20130072714
    Abstract: A composition comprising between 95 and 100% biobased succinic acid, MAS or DAS wherein at least 75% of the carbons are biobased.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: BioAmber International S.à.r.l.
    Inventors: Roger L. Bernier, Michael C.M. Cockrem, Dilum Dunuwila, James R. Millis
  • Production of isoprenoids
    Patent number: 8241888
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: August 14, 2012
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 8236552
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: August 7, 2012
    Assignee: Arkion Life Sciences
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of Isoprenoids
    Publication number: 20110195470
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Application
    Filed: April 18, 2011
    Publication date: August 11, 2011
    Applicant: ARKION LIFE SCIENCES, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Method for making industrial chemicals
    Patent number: 7960599
    Abstract: A process for producing industrially important chemicals from renewable resources is disclosed. This “biobased” process employs readily available, renewable resources comprising fatty acids rather than exploiting fossil sources, such as coal and petroleum. In one embodiment of the process 1-octene, along with methyl-9-decenoate and butadiene, is produced from linoleic acid via an enzymemediated isomerization reaction, followed by a metathesis reaction with ethylene. Linoleic acid can be isolated from vegetable oils, such as soybean oil.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: June 14, 2011
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: James R. Millis, Michael J. Tupy, Timothy W. Abraham, Mervyn L. De Souza
  • Production of isoprenoids
    Patent number: 7927861
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: April 19, 2011
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 7927862
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: April 19, 2011
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • PRODUCTION OF ISOPRENOIDS
    Publication number: 20110059515
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Application
    Filed: November 9, 2010
    Publication date: March 10, 2011
    Inventors: JAMES R. MILLIS, JULIE MAURINA-BRUNKER, THOMAS W. MCMULLIN
  • PRODUCTION OF ISOPRENOIDS
    Publication number: 20110059516
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Application
    Filed: November 9, 2010
    Publication date: March 10, 2011
    Inventors: JAMES R. MILLIS, JULIE MAURINA-BRUNKER, THOMAS W. MCMULLIN
  • Production of isoprenoids
    Patent number: 7842497
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 30, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 7838279
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 7732161
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: June 8, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 7718417
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: May 18, 2010
    Assignee: Bio-Technical Resources, a division of Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin