Patents by Inventor James R. Millis

James R. Millis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100035329
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Application
    Filed: July 27, 2009
    Publication date: February 11, 2010
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 7572607
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: August 11, 2009
    Assignee: Cargill, Incorporated
    Inventors: Paula M. Hicks, Sara C. McFarlan, Timothy W. Abraham, Douglas C. Cameron, James R. Millis, John Rosazza, Lishan Zhao, David Paul Weiner
  • Publication number: 20090130285
    Abstract: The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: November 14, 2008
    Publication date: May 21, 2009
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Melanie J. Goulson, Paula M. Hicks, Michael G. Lindley, Sara C. McFarlan, James R. Millis, John Rosazza, Lishan Zhao, David P. Weiner
  • Publication number: 20090017520
    Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
    Type: Application
    Filed: June 22, 2007
    Publication date: January 15, 2009
    Applicant: Arkion Life Sciences LLC d/b/a Bio-Technical Resources
    Inventors: Alan Berry, Richard P. Burlingame, James R. Millis
  • Publication number: 20040110257
    Abstract: The invention provides a biological method of producing farnesol or geranylgeraniol.
    Type: Application
    Filed: November 20, 2003
    Publication date: June 10, 2004
    Applicant: Arkion Life Sciences LLC.
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 6689593
    Abstract: The invention provides a biological method of producing farnesol or geranylgeraniol.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 10, 2004
    Assignee: Arkion Life Sciences LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Publication number: 20030125573
    Abstract: The invention provides a method of producing &agr;-tocopherol and &agr;-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into &agr;-tocopherol or an &agr;-tocopheryl ester.
    Type: Application
    Filed: July 9, 2001
    Publication date: July 3, 2003
    Applicant: DCV, Inc., d/b/a Bio-Technical Resources
    Inventors: James R. Millis, Gabriel G. Saucy, Julie Maurina-Brunker, Thomas W. McMullin
  • Publication number: 20030092144
    Abstract: The invention provides a biological method of producing farnesol or geranylgeraniol.
    Type: Application
    Filed: July 20, 2001
    Publication date: May 15, 2003
    Applicant: DCV, Inc. d/b/a Bio-Technical Resources.
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 6531303
    Abstract: The invention provides a biological method of producing geranylgeraniol.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: March 11, 2003
    Assignee: Arkion Life Sciences LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Publication number: 20030044939
    Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucsamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
    Type: Application
    Filed: December 17, 2001
    Publication date: March 6, 2003
    Applicant: Arkion Life Sciences LLC
    Inventors: Alan Berry, Richard P. Burlingame, James R. Millis
  • Publication number: 20020160459
    Abstract: The present invention relates to a method for producing N-glucosamine by fermentation of a genetically modified microorganism.
    Type: Application
    Filed: September 15, 1999
    Publication date: October 31, 2002
    Inventors: ALAN BERRY, RICHARD P. BURLINGAME, JAMES R. MILLIS
  • Patent number: 6410755
    Abstract: The invention provides a method of producing &agr;-tocopherol and &agr;-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into &agr;-tocopherol or an &agr;-tocopheryl ester.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: June 25, 2002
    Assignee: DCV, Inc.
    Inventors: James R. Millis, Gabriel G. Saucy, Julie Maurina-Brunker, Thomas W. McMullin
  • Patent number: 6372457
    Abstract: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucsamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant nucleic acid molecules.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: April 16, 2002
    Assignee: Arkion Life Sciences LLC
    Inventors: Alan Berry, Richard P. Burlingame, James R. Millis
  • Patent number: 6242227
    Abstract: The invention provides a method of producing &agr;-tocopherol and &agr;-tocopheryl esters. The method comprises using a biological system to produce farnesol or geranylgeraniol. Then, the farnesol or geranylgernaiol is chemically converted into &agr;-tocopherol or an &agr;-tocopheryl ester.
    Type: Grant
    Filed: July 6, 1999
    Date of Patent: June 5, 2001
    Assignees: DCV, Inc., Eastman Chemical Company
    Inventors: James R. Millis, Gabriel G. Saucy, Julie Maurina-Brunker, Thomas W. McMullin, John A. Hyatt
  • Patent number: 6136985
    Abstract: The present invention provides CLA esters and uses thereof. More particularly, the present invention provides a composition for topical use comprising CLA esters and a topical carrier. In addition, the present invention specifically provides tocopheryl CLA esters, ascorbyl CLA esters and retinyl CLA esters.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 24, 2000
    Assignee: DCV, Inc.
    Inventor: James R. Millis
  • Patent number: 5902579
    Abstract: Natamycin biomass comprising 5-60% natamycin, most preferably 25-60% natamycin, and methods for forming the biomass, are disclosed. The natamycin biomass can be mixed with compatible carrier to form a premix comprising 0.2-5% natamycin. The premlix may be mixed with animal feed to form an animal feed mixture comprising cracked grain and 1.1-110 ppm of natamycin.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: May 11, 1999
    Assignee: Bio-Technical Resources
    Inventors: Michael Alan Eisenschink, James R. Millis, Phillip Terry Olson, Bruce Dexter King, Mary Ellen Rowland
  • Patent number: 5866379
    Abstract: Enzymes derived from the isolated and substantially purified microorganisms of the present invention, designated herein as strains 52 and 56wt, are capable of hydrating nitriles such as 2-hydroxy-4-(methylthio)-butanenitrile (HMB-nitrile) to their corresponding amides, and further, of hydrolyzing amides such as 2-hydroxy-4-(methylthio)-butaneamide (HMB-amide) to their corresponding carboxylic acids. Advantageously, the nitrile hydratase of these strains is not substantially inhibited by the .alpha.-hydroxybutyramide product being formed; rather, this enzyme maintains the ability to hydrate an .alpha.-hydroxybutyronitrile to its corresponding amide even at high amide concentrations, including at saturating amide conditions. As such, enzymes derived from strains 52 and 56wt are particularly suited for commercial use in preparing agrichemical intermediates such as HMB-amide.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: February 2, 1999
    Assignee: Novus International
    Inventors: Richard P. Burlingame, James R. Millis, Fernando Sanchez-Riera, Thomas F. Blackburn, Alan D. Grund
  • Patent number: 5686273
    Abstract: An improved method for producing natamycin by fermentation is disclosed.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: November 11, 1997
    Assignee: Cultor Food Science, Inc.
    Inventors: Michael Allen Eisenschink, James R. Millis, Phillip Terry Olson
  • Patent number: 5591438
    Abstract: A process for the recovery of high purity natamycin from fermentaion broth by extraction with methanol is disclosed. In one embodiment the process comprises the steps:(1) adding methanol to a natamycin feed stream comprising at least 2 g/L of solid suspended natamycin to form an extraction medium, and maintaining the extraction medium at a temperature of 0.degree.-25.degree. C., preferably not over 15.degree. C.;(2) adjusting the pH of the extraction medium to 1.0 to 4.5 while maintaining the temperature at 0.degree.-25.degree. C. for 0.5 to 30 hours, but preferably not over 0.5 hours when the temperature is 15.degree.-25.degree. C.;(3) removing solids from the extraction medium to form an extraction liquor;(4) raising the pH of the extraction liquor to 6.0-9.0; and(5) recovering precipitated natamycin.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: January 7, 1997
    Assignee: Bio-Technical Resources L.P.
    Inventors: Phillip T. Olson, James R. Millis, Michael H. Reimer
  • Patent number: 5286506
    Abstract: The protection of food products from contamination by food pathogens, particularly Listeria monocytogenes, by incorporation of 6 to 50 ppm and preferably 6 to 15 ppm of beta-acids, as extracted from hops, into such food products.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: February 15, 1994
    Assignee: Bio-Technical Resources
    Inventors: James R. Millis, Mark J. Schendel