Abstract: Embodiments of the invention are directed to a deposition chamber for forming a poly-para-xylylene film. A non-limiting example of the deposition chamber includes a chamber body, an inlet coupling the chamber body to a furnace, and an outlet coupling the chamber body to a vacuum pump. The deposition chamber includes at least one heating element arranged on a surface of the chamber body. The heating element is configured to raise an internal temperature of the deposition chamber body to a substantially uniform internal temperature across an entire internal volume of the chamber body.

Abstract: A haptic driver for driving a haptic actuator, the haptic driver configured to: provide a haptic drive signal and an audio drive signal, the haptic drive signal for causing the haptic actuator to generate a haptic vibration output and the audio drive signal for causing the haptic actuator to generate an audio output; and drive the haptic actuator with the haptic drive signal and the audio drive signal so that the haptic actuator generates the haptic vibration output and the audio output.

Abstract: A vehicle health record system and method are described herein that stores comprehensive vehicle data selected from the group consisting of vehicle identification number, vehicle build data, department of motor vehicle data, vehicle parts data, vehicle maintenance data, vehicle repair data, collision data, insurance claim data, vehicle diagnostic data, recall data, vehicle pricing data, and connected car data in a blockchain to provide accurate and reliable representation of a vehicle's history that may be used by a variety of end users for transactions related to the vehicles, including uses related to buy-sell, maintenance, repairs, and insurance transactions. The system further uses artificial intelligence and machine learning technologies to gain insight and provide value-added derivative products and services to all entities engaged in transactions related to vehicles. The system and method described herein can be applied to all types of valuable vehicles and machinery.

Abstract: A method of evaluating current sensor measurements of an electric machine system includes acquiring a first current signal corresponding to a first measurement of a first phase current of a three phase electric current supply to an electric machine, and acquiring a second current signal corresponding to a second measurement of a second phase current of the three phase electric current supply. The method also includes determining a machine velocity, shifting the first current signal by a signal processing component to generate a shifted first current signal having a shifted phase, the signal processing component including a tuning parameter that is a function of the machine velocity, calculating an amplitude difference between the shifted first current signal and the second current signal, and determining a plausibility of the first measurement and the second measurement based on the difference.

Abstract: A method of evaluating current sensor measurements of an electric machine system includes acquiring a first current signal corresponding to a first measurement of a first phase current of a three phase electric current supply to an electric machine, and acquiring a second current signal corresponding to a second measurement of a second phase current of the three phase electric current supply. The method also includes determining a machine velocity, shifting the first current signal by a signal processing component to generate a shifted first current signal having a shifted phase, the signal processing component including a tuning parameter that is a function of the machine velocity, calculating an amplitude difference between the shifted first current signal and the second current signal, and determining a plausibility of the first measurement and the second measurement based on the difference.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: An abrasive article (100) comprising a backing (102); a make resin (112) contacting the backing (102); abrasive particles (114) contacting the make resin (112); and a size resin (116) contacting both the abrasive particles (114) and the make resin (112), wherein the make resin (112) includes an alkyl quaternary ammonium clay, which can take the form of Garamite.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: Embodiments of the invention are directed to a deposition chamber for forming a poly-para-xylylene film. A non-limiting example of the deposition chamber includes a chamber body, an inlet coupling the chamber body to a furnace, and an outlet coupling the chamber body to a vacuum pump. The deposition chamber includes at least one heating element arranged on a surface of the chamber body. The heating element is configured to raise an internal temperature of the deposition chamber body to a substantially uniform internal temperature across an entire internal volume of the chamber body.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A mold is provided. First and second materials are introduced into respective first and second portions of the mold to create a first and second parts of the item. The first and second parts of the item are allowed to solidify. The mold is opened and a heating element is inserted into the mold. A section of each of the first and second parts of the item is heated to above their glass transition temperatures with the heating element. The heating element is removed from the mold. The mold is closed such that the sections of the first and second parts of the item come into contact with each other. The sections of the first and second parts are cooled to below their glass transition temperatures to become joined. The mold is opened such that the item can be removed from the mold.

Abstract: A process for treating tumors by administering a mixture of cancer fighting drugs incorporated into a stabilized liposomal formulation. Each cancer drug is selected to target a different phase of the cell-cycle of the cancer cell thus expanding the number of cancer cells that can be killed at one time without compromising the safety of the patient. The stabilized multi-drug liposomes are designed to extravasate thru “leaky” blood capillaries supplying the tumor and enter the tumor tissue where they will accumulate over time and ultimately release the mixture of cancer drugs to kill surrounding tumor cells. The multi-drug liposomes are likewise unable to extravasate thru normal blood capillaries and will thus be less toxic to normal tissues.

Abstract: An abrasive article (100) comprising a backing (102); a make resin (112) contacting the backing (102); abrasive particles (114) contacting the make resin (112); and a size resin (116) contacting both the abrasive particles (114) and the make resin (112), wherein the make resin (112) includes an alkyl quaternary ammonium clay, which can take the form of Garamite.

Abstract: This invention uses “Targeted Apheresis” to treat patients with Rheumatoid Arthritis and other autoimmune and inflammatory disorders. “Targeted Apheresis” is a process whereby only the pathogenic and pro-inflammatory elements associated with the disease symptoms are simultaneously and selectively removed from the blood by passing the blood through an extracorporeal affinity device containing selective binding agents. Removal of these pathogenic and pro-inflammatory elements will ameliorate the symptoms of autoimmune disease and may prolong the period of disease remission.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitabale for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A composition of chlorine-free poly-oxygenated aluminum hydroxide that comprises a clathrate containing oxygen gas molecules. In one embodiment, the poly-oxygenated aluminum hydroxide has particles having a diameter of 212 microns or less. The composition may be homogeneous.

Abstract: A mold is provided. First and second materials are introduced into respective first and second portions of the mold to create a first and second parts of the item. The first and second parts of the item are allowed to solidify. The mold is opened and a heating element is inserted into the mold. A section of each of the first and second parts of the item is heated to above their glass transition temperatures with the heating element. The heating element is removed from the mold. The mold is closed such that the sections of the first and second parts of the item come into contact with each other. The sections of the first and second parts are cooled to below their glass transition temperatures to become joined. The mold is opened such that the item can be removed from the mold.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

Abstract: A composition of chlorine-free poly-oxygenated aluminum hydroxide that comprises a clathrate containing oxygen gas molecules, In one embodiment, the poly-oxygenated aluminum hydroxide has particles having a diameter of 212 microns or less. The composition may be homogeneous.

Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Spearation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.