Abstract: A compound of formula (1) and pharmaceutically acceptable salts thereof for use in the treatment of chemokine mediated diseases and conditions.

Abstract: The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.

Abstract: A valve assembly for a dunnage bag wherein in one embodiment of the valve a valve diaphragm is mounted on a shaft and is supported by a mounting bar such that the valve diaphragm may be reciprocally moved from the closed position to the open position by a simple axial push on the valve shaft. The valve shaft is retained in the mounting bar in an orifice and the shaft diameter is enlarged at its end distant from the valve diaphragm so as to generate a frictional force fit or lock in the open position to facilitate the removal of air from the bag. The valve may be released form the friction lock by the air pressure of a recharged bag and/or by the manual movement of the valve diaphragm and shaft axially toward the open end of the valve assembly. In an alternate embodiment, the valve diaphragm is mounted to a valve stem that it rotationally and axially moveably connected to the valve body.

Abstract: A system and method are provided to allow demand loading and discarding of Java executable image (JXE) files. The virtual machine allocates an address space for a requested JXE program. The read-only portion of the JXE file is memory mapped from its nonvolatile location to the allocated memory space using read-only mapping and the read/write section of the JXE file are loaded into memory. When a page of the JXE program is needed, a page fault occurs if the read-only portion has not been loaded into memory. The operating system's page fault handler retrieves the needed page(s) from the nonvolatile storage location based upon the mapping data that resulted from the previously performed memory mapping. Because the read-only section of the JXE file is memory mapped using read-only mapping, the operating system's paging process is free to discard previously loaded memory pages that contain read-only portions of the JXE file.

Abstract: A valve assembly for a dunnage bag wherein in the valve body a valve diaphragm is mounted on a shaft and is supported by a mounting bar such that the valve diaphragm may be reciprocally moved from the closed position to the open position by a simple axial push on the valve shaft. The valve shaft is retained in the mounting bar in an orifice and the shaft diameter is enlarged at its end distant from the valve diaphragm so as to generate a frictional force fit or lock in the open position to facilitate the removal of air from the bag. The valve may be released form the friction lock by the air pressure of a recharged bag and/or by the manual movement of the valve diaphragm and shaft axially toward the open end of the valve assembly.

Abstract: A tuneable laser is disclosed, including a gain section with first and second comb reflectors to one side thereof. The two reflectors each provide combs with substantially uniform spacings, the spacings differing as between the combs. Each comb reflector can be tuned so as to shift the reflective peaks of the combs, thus allowing alignment of a single reflective peak at a chosen wavelength which is the same in both combs, forming a supermode. This supermode has an intensity greater than the threshold of the gain section and thus the laser produces an output at that selected wavelength.

Abstract: A wheeled vehicle includes a front steered wheel, a rear driven wheel, and a support member that supports a rider. A main structural tube is disposed substantially horizontally along a longitudinal axis for supporting the front steered wheel at a forward end of the main structural tube, for supporting the rear driven wheel at a rear end of the main structural tube, and for supporting a rider who controls and steers the wheeled vehicle. An improved torsion acting shock absorbing mount is disclosed for the cantilevered shock absorbing support of at least one of the vehicle wheels from the frame. The torsion acting shock absorber includes a square sectioned metal tube, a correspondingly square sectioned metal shaft, and confined compressible resilient compound rods acting there between. The torsion acting shock absorber is attached at right angles to the main structural tube.

Abstract: Provided is a method for managing sets of OSGi bundles in a manner that enables a developer to control the order in which bundles are activated, both within and among OSGi start levels. Also provided is a method for eliminating multiple instances of the OSGi class loaders that are typically generated for each bundle. A bundle consolidator tool is provided that combines multiple bundles in a set of bundles into a master bundle that appears to the OSGi framework to be a single bundle. An activator method enables the developer to specify the order in which individual bundles are initiated and terminated. In addition, a single class loader thread is employed to activate the individual bundles. The bundle consolidator tool also analyzes the target bundles for name space collisions and, in the event a collision is detected, the tool is programmed to modify byte codes to eliminate the collision.

Abstract: Method and apparatus for providing GPS pseudorange correction and carrier phase correction information for navigation or surveying activities over a selected geographic region S of arbitrary size. In a navigation mode, a virtual reference station (VRS), positioned near a selected location L, receives differential GPS (DGPS) correction signals, translates these signals into a selected format, and broadcasts this DGPS information in this format for use by a local user. In a survey mode, the VRS receives corrected GPS information, translates this information into a selected format and broadcasts this translated and corrected GPS information and the VRS location, for use by a mobile station in forming a baseline vector from the GPS mobile station to the VRS location.

Abstract: A tuneable laser has a gain section bounded at one end by a first reflector in the form of a distributed Bragg reflector adapted to produce a comb of reflective peaks and on the other end by a second Bragg reflector, the second Bragg reflector adapted to reflect at a plurality of wavelengths and being capable of being varied selectively through discrete segments so that one or more segments of the Bragg reflector can be tuned to a lower wavelength to reflect with a segment reflecting at that lower wavelength to enhance the reflectivity at that lower wavelength.

Abstract: The present invention is an orally administered liquid pharmaceutical composition that demonstrates excellent physical stability while delivering concentrated levels of the pharmaceutical active(s). Specifically, these compositions for extended periods do not allow the active to precipitate or settle out of solution. Among the advantages of this invention is that the compositions do not require agitation/shaking prior to use as a method to re-suspend or dissolve active drug material to insure even and consistent dosing.

Abstract: The present invention is a method for enabling a trusted dialog for collection of sensitive data, including the steps of: storing a personal security token specified by a user; receiving an input dialog request from an application; determining whether the application is a signed application; and, if a determination is made that the application is a signed application, accessing the personal security token and allowing the input dialog to be displayed with the personal security token and signed application identification. The personal security token may be at least one of an audible recording or a set of vibratory motions.

Abstract: The invention relates to liquid sulphur-containing antioxidants and to compositions comprising them. The novel lubricant comprise the reaction product of a selected group of 5-tert-butyl-4-hydroxy-3-methyl(or tert-butyl)phenyl substituted carboxylic acid esters with thiodiethylene glycol and a mono-hydroxy alcohol with a carbon chain length higher than 4 C-atoms. The novel lubricant compositions are highly resistant to oxidative degradation and are capable of reducing the negative effects of deposits, such as black sludge, in motor combustion engines, particularly spark ignition internal combustion engines.

Abstract: The invention relates to liquid sulphur-containing antioxidants and to compositions comprising them. The novel lubricant compositions comprise the reaction product of a selected group of 5-tert-butyl-4-hydroxy-3-methyl(or tert-butyl)phenyl substituted carboxylic acid esters with thiodiethylene glycol and a mono-hydroxy alcohol with a carbon chain length higher than 4 C-atoms. The novel lubricant compositions are highly resistant to oxidative degradation and are capable of reducing the negative effects of deposits, such as black sludge, in motor combustion engines, particularly spark ignition internal combustion engines.

Abstract: Method and apparatus for providing GPS pseudorange correction and carrier phase correction information for navigation or surveying activities over a selected geographic region S of arbitrary size. In a navigation mode, a virtual reference station (VRS), positioned near a selected location L, receives differential GPS (DGPS) correction signals, translates these signals into a selected format, and broadcasts this DGPS information in this format for use by a local user. In a survey mode, the VRS receives corrected GPS information, translates this information into a selected format and broadcasts this translated and corrected GPS information and the VRS location, for use by a mobile station in forming a baseline vector from the GPS mobile station to the VRS location.

Abstract: A system and method for reclaiming memory occupied by compiled code resulting from a Just-in-Time (JIT) compiler is provided. An address space used to store code resulting from a JIT compiler is memory mapped using a special filesystem. A map is maintained identify method name and corresponding JIT pages. When the memory manager needs more space, it requests that the special filesystem write the data from memory back to nonvolatile storage. The special filesystem acts as if the data was written. When the code is subsequently called, a page fault and an invalid operation exception occur and are handled. The data in the map is used to recompile the method to the same address space and the faulting instruction is re-executed.

Abstract: A system and method are provided to allow demand loading and discarding of Java executable image (JXE) files. The virtual machine allocates an address space for a requested JXE program. The read-only portion of the JXE file is memory mapped from its nonvolatile location to the allocated memory space using read-only mapping and the read/write section of the JXE file are loaded into memory. When a page of the JXE program is needed, a page fault occurs if the read-only portion has not been loaded into memory. The operating system's page fault handler retrieves the needed page(s) from the nonvolatile storage location based upon the mapping data that resulted from the previously performed memory mapping. Because the read-only section of the JXE file is memory mapped using read-only mapping, the operating system's paging process is free to discard previously loaded memory pages that contain read-only portions of the JXE file.

Abstract: A low gloss dry-erasable multilayer composite comprises a first layer having a dry-erasable outer surface and a second layer having a microroughened surface. Preferably, the second layer is microroughened by cure-induced surface wrinkling. The first layer preferably comprises a polymer comprising at least one pendant fluoroalkoxyalkyl functionality. Methods of making low gloss dry erasable multilayer composites are also provided. New dry-erasable coating compositions comprising certain amine resin crosslinking agents are also provided.

Abstract: The present invention pertains to compositions having improved delivery of pharmaceutical actives. These compositions comprise pharmaceutical actives in an anhydrous solvent. These compositions may take the form of liquid elixirs placed into the mouth and eventually swallowed, or can be delivered via liquid-filled drops, metered liquid dosing devices, atomizers and liquid-releasing, edible capsules.

Abstract: The invention relates to liquid sulphur-containing antioxidants and to compositions comprising them. The novel lubricant compositions comprise the reaction product of a selected group of 5-tert-butyl-4-hydroxy-3-methyl(or tert-butyl)phenyl substituted carboxylic acid esters with thiodiethylene glycol and a mono-hydroxy alcohol with a carbon chain length higher than 4 C-atoms. The novel lubricant compositions are highly resistant to oxidative degradation and are capable of reducing the negative effects of deposits, such as black sludge, in motor combustion engines, particularly spark ignition internal combustion engines.