Abstract: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Abstract: A hot spot filter for a light guide is created by taking an image of the light output pattern of an illiuminated light guide. The hot spot filter may be a film, a layer, or an additional liquid crystal display dedicated to attenuating bright spots from the light guide. The hot spot filter may be incorporated into the image display by adjusting the grey scale of individual pixels to provide sufficient compensation.

Abstract: The invention provides a printed circuit board (PCB) for use in an electronic device. The PCB comprises: a top side; a bottom side; an edge between the top side and the bottom side; a cavity from the top side to the bottom side; a region on the top side for mounting an electronic device; and a connector for receiving connections from the electronic device. In the PCB, the connector is located on either the bottom side or the edge of the side of the PCB. The electronic device can be a display module.

Abstract: A wireless handheld communications device with a liquid crystal display, especially, a field sequential liquid crystal display, includes a visual notification for a powered up, inactive state. The visual notification is preferably through a light emitting diode that may be part of the backlighting system for the LCD or may be independent from the backlighting system. The waveforms, periodicity, colour selection, and colour sequencing may be customizable by one or both of the manufacturer and user.

Abstract: A touchscreen liquid crystal display that includes a liquid crystal display including a viewing surface, a liquid crystal area containing liquid crystal located behind the viewing surface, a plurality of spaced apart elongate first electrodes located on a viewing surface side of the liquid crystal area and a plurality of spaced apart elongate second electrodes located on an opposite side of the liquid crystal area, the first and second electrodes overlapping to form an array of liquid crystal pixel elements, at least some of the first electrodes being displaceable towards the second electrodes in response to external pressure applied to the viewing surface. A control circuit is connected to the first and second electrodes for controlling the operation of the liquid crystal display.

Abstract: A process for regenerating a palladium catalyst from a catalytic reaction where the catalyst is contaminated with at least carbon. The regenerating is conducted prior to any heating step under oxidizing conditions in the regenerating section. The regenerating involves at least one heating step under a hydrogen-containing reducing atmosphere and under conditions sufficient to lower the content of carbon in the palladium catalyst.

Abstract: Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.

Abstract: The present invention is directed to a field-mounted analyzer having a graphical user interface (GUI). The analyzer has a display screen visible from the exterior of the housing. A plurality of magnetically-actuatable switches are mounted behind the display screen. The GUI has a plurality of windows that may be displayed on the display screen. Navigation through the windows is accomplished by activating switches aligned with graphical navigation icons in the windows.

Abstract: A method for reducing cross-talk on a liquid crystal display begins by receiving pixel data defining an image comprising a plurality of pixels; the received pixel data includes an intensity value associated with each pixel. The image is compressed by reducing the range of the intensity values of all the pixels in the image; the compressing step comprising arithmetically adjusting the intensity values of the pixels. Lines in the compressed image that are disposed to create cross-talk are identified. The image is then decompressed by applying a scale factor to the adjusted intensity value associated only with the pixels in the identified lines. The scale factor is selected such that a display image rendered on a liquid crystal display from the pixel data of the decompressed image has less cross-talk than a display image rendered on a liquid crystal display from the received pixel data.

Abstract: A mobile wireless communications device includes a housing and circuit board carried by the housing and includes radio frequency (RF) circuitry and a processor carried by the circuit board and operative with each other. A display connector for an LCD connector is mounted on the circuit board and adapted to be connected to a display. Display connection lines are carried by the circuit board and interconnect the display connector and processor for carrying signals from the processor to the display connector and a connected display. Filters are carried by the circuit board and connected to the display connection lines and reduce any interfering energy from the processor and display.

Abstract: A bone screw removal system for a bone screw retaining system that includes an implant having a plate, which defines a plurality of transversely extending bores that are configured to receive a bone screw for engaging the plate to the cervical spine, and an elastically deformable spring member positioned therein a cavity of the plate such that portions of the spring member can extend into a portion of an upper region of each of the bores of a pair of opposing bores, the spring member being movable between a first relaxed, expanded position and a second, compressed position. The bone screw removal system having at least one tongue member that is configured to selectively act on the spring member of the bone screw retaining system.

Abstract: A touchscreen liquid crystal display, method for using a liquid crystal display as a user input, and a mobile electronic device are provided.

Abstract: A mobile wireless communications device includes a housing and circuit board carried by the housing and includes radio frequency (RF) circuitry and a processor carried by the circuit board and operative with each other. A display connector for an LCD connector is mounted on the circuit board and adapted to be connected to a display. Display connection lines are carried by the circuit board and interconnect the display connector and processor for carrying signals from the processor to the display connector and a connected display. Filters are carried by the circuit board and connected to the display connection lines and reduce any interfering energy from the processor and display.

Abstract: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Abstract: A hot spot filter for a light guide is created by taking an image of the light output pattern of an illuminated light guide. The hot spot filter may be a film, a layer, or an additional liquid crystal display dedicated to attenuating bright spots from the light guide. The hot spot filter may be incorporated into the image display by adjusting the grey scale of individual pixels to provide sufficient compensation.

Abstract: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Abstract: The present invention provides compounds and methods that can be used to convert the intermmediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

Abstract: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Abstract: The invention provides a system and method for calculating a backlight level for an image being displayed on an electronic device. The system comprises: a backlight adjustment module to calculate an intensity value of an image for display on the electronic device; a display for displaying the image; and a backlight system to provide a backlight for the display. The backlight system is responsive to control signals generated by the backlight adjustment module. In the system, the intensity value represents an average intensity of the image.

Abstract: A method is set forth for automatically adjusting screen and keypad brightness on a mobile electronic device having a light sensor, display screen and keypad, for optimum legibility under varying lighting conditions, with minimal eye strain and distraction to the user. The method includes obtaining light level samples from the light sensor, and independently adjusting backlight intensity of the display screen and keypad responsive to the light level samples. Preferably, correct screen and keypad adjustments are made responsive to the user pulling his or her handheld device out of its holster notwithstanding non-optimal ambient light detection while the device is being removed from the holster. According to another aspect, the described method allows for ambient light detection in a handheld device where the light sensor and a message notification indicator share a common light pipe.