Patents by Inventor James Rolke

James Rolke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANGIOTENSIN COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20220160816
    Abstract: Provided herein are dosage forms and kits comprising angiotensin II that are suitable for the treatment of low blood pressure. In particular, dosage forms and kits that facilitate the ability to rapidly prepare angiotensin II for IV infusion into a subject.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 26, 2022
    Inventor: James Rolke
  • COMPOSITIONS COMPRISING HEPCIDIN AND METHODS OF USE THEREOF
    Publication number: 20190315821
    Abstract: Provided herein are improved compositions comprising hepcidin. In some aspects, provided herein are methods of treating a condition with a composition disclosed herein.
    Type: Application
    Filed: February 22, 2019
    Publication date: October 17, 2019
    Inventors: James Rolke, Harry Wang
  • ANGIOTENSIN COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20190183962
    Abstract: Provided herein are dosage forms and kits comprising angiotensin II that are suitable for the treatment of low blood pressure. In particular, dosage forms and kits that facilitate the ability to rapidly prepare angiotensin II for IV infusion into a subject.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 20, 2019
    Inventor: James Rolke
  • Glucan preparations
    Patent number: 10272101
    Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 30, 2019
    Assignee: BIOTHERA INC.
    Inventors: Andrew Magee, James Rolke, Ren-der Yang
  • GLUCAN PREPARATIONS
    Publication number: 20170304352
    Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.
    Type: Application
    Filed: February 21, 2017
    Publication date: October 26, 2017
    Inventors: Andrew MAGEE, James ROLKE, Ren-der YANG
  • COMPOSITIONS AND METHODS RELATED TO GENTAMICIN
    Publication number: 20170218005
    Abstract: Various aspects of the invention relate to compositions comprising C-2a gentamicin. A composition may be substantially free from one or more of C-1 gentamicin, C-1a gentamicin, C-2 gentamicin, C-2b gentamicin, gentamicin A, gentamicin B, and gentamicin X. In some aspects, the invention relates to a method for treating a condition in a subject, comprising administering a composition comprising C-2a gentamicin to the subject. The condition may be, for example, a bacterial infection, genetic disease or disorder, or cancer.
    Type: Application
    Filed: January 27, 2017
    Publication date: August 3, 2017
    Inventors: George Tidmarsh, James Rolke, Lakhmir Chawla
  • Glucan preparations
    Patent number: 9610303
    Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: April 4, 2017
    Assignee: BIOTHERA, INC.
    Inventors: Andrew Magee, James Rolke, Ren-der Yang
  • COMPOSITIONS AND METHODS FOR ADMINISTERING GALECTIN ANTAGONISTS
    Publication number: 20170014446
    Abstract: The invention provides methods for the treatment of diseases and conditions relating to galectin 3 using a galectin-3 inhibitor, such as a modified pectin (e.g., GCS-100). Also described are methods for conjoint therapy, and methods for assessing and/or monitoring the effects of a galectin-3 inhibitor, e.g., to adapt the dosing regimen of the inhibitor during therapy.
    Type: Application
    Filed: March 10, 2015
    Publication date: January 19, 2017
    Applicant: LA JOLLA PHARMACEUTICAL COMPANY
    Inventors: James Rolke, George Tidmarsh
  • Modified Pectins, Compositions and Methods Related Thereto
    Publication number: 20160030467
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Application
    Filed: August 27, 2015
    Publication date: February 4, 2016
    Inventors: Mark Staples, James Rolke
  • Modified pectins, compositions and methods related thereto
    Patent number: 9181354
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: November 10, 2015
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • MODIFIED PECTINS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20150086642
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Application
    Filed: October 30, 2014
    Publication date: March 26, 2015
    Inventors: Mark Staples, James Rolke
  • Modified pectins, compositions and methods related thereto
    Patent number: 8877263
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: November 4, 2014
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • Modified Pectins, Compositions and Methods Related Thereto
    Publication number: 20140228317
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Application
    Filed: April 16, 2014
    Publication date: August 14, 2014
    Applicant: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • Modified pectins, compositions and methods related thereto
    Patent number: 8722107
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: May 13, 2014
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • Modified pectins, compositions and methods related thereto
    Patent number: 8722111
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: May 13, 2014
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • Modified pectins, compositions and methods related thereto
    Patent number: 8658224
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: February 25, 2014
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Mark Staples, James Rolke
  • Pharmaceutical Formulations of Biodegradable Biocompatible Camptothecin-Polymer Conjugates
    Publication number: 20140004074
    Abstract: A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.
    Type: Application
    Filed: June 18, 2013
    Publication date: January 2, 2014
    Applicant: Mersana Therapeutics, Inc.
    Inventors: James Rolke, Russell C. Petter, Mao Yin, Aleksandr V. Yurkovetskiy, Gui Liu, Emile Farhan
  • MODIFIED PECTINS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20130251765
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 26, 2013
    Applicant: LA JOLLA PHARMACEUTICAL COMPANY
    Inventors: Mark Staples, James Rolke
  • MODIFIED PECTINS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20130243831
    Abstract: The present invention provides compositions of modified pectin and methods for preparing and using them.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 19, 2013
    Applicant: LA JOLLA PHARMACEUTICAL COMPANY
    Inventors: Mark Staples, James Rolke
  • Pharmaceutical formulations of biodegradable biocompatible camptothecin-polymer conjugates
    Patent number: 8491880
    Abstract: A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: July 23, 2013
    Assignee: Mersana Therapeutics, Inc.
    Inventors: James Rolke, Russell C. Petter, Mao Yin, Aleksandr Yurkovetskiy, Gui Liu, Emile Farhan