Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A luminaire includes a frame having a lightguide and at least one light emitting diode disposed to direct light into an edge of the lightguide. A low voltage power cable delivers power to the at least one light emitting diode. A plurality of suspension cables are attached to the frame for suspending the luminaire. At least one acoustic panel is attached to the frame.

Abstract: A luminaire includes a light module, the light module including a first acoustic panel, a second acoustic panel, and a lightguide disposed between the first acoustic panel and the second acoustic panel. The lightguide can extend from the first acoustic panel and the second acoustic panel. A frame is disposed between the first acoustic panel and the second acoustic panel and secures an edge of the lightguide within the light module. A light emitting diode is located within the frame and oriented to emit light into the edge of the lightguide.

Abstract: A luminaire includes a frame having a lightguide and at least one light emitting diode disposed to direct light into an edge of the lightguide. A low voltage power cable delivers power to the at least one light emitting diode. A plurality of suspension cables are attached to the frame for suspending the luminaire. At least one acoustic panel is attached to the frame.

Abstract: Described include various embodiments of an integrated multi-level network appliance and system, and remote management system and method therefor. In one embodiment, the appliance can comprise: two or more hardware-integrated processing engines each operable to implement a corresponding network-related resource associated with a respective network level in accordance with a designated multi-level network architecture; an integrated processor operable to execute the processing engines; one or more integrated data storage resources accessible to the processing engines to implement each corresponding network-related resource; and a trusted single-chip switch having a plurality of hardware ports associated therewith and configured to define in hardware multiple data communication paths embedded therein.

Abstract: Described are various embodiments of a hardware security module. For example, in one embodiment, a hardware security module is described to comprise: two or more hardware ports, each one of which operable to electronically receive given input hardware port-specific cryptographic data thereon to initiate execution of an internal cryptographic process as a function thereof; two or more segregated hardware port-specific storage spaces each operatively linked to a corresponding one of said hardware ports via a corresponding hardware link, and storing respective secured hardware port-specific cryptographic data thereon exclusively retrievable as a function of said given input hardware port-specific cryptographic data corresponding thereto; and a cryptographic engine operable to execute said cryptographic process based on said secured port-specific cryptographic data retrieved from said segregated hardware port-specific storage spaces as a function of said given input port-specific cryptographic data.

Abstract: Described are various embodiments of a machine executable code deployment method and system. In one such embodiment, a machine executable code deployment method is described to comprise: compiling machine readable code in a secure digital processing environment to produce a unique ephemeral machine executable code instance representative thereof; deploying the unique ephemeral machine executable code instance to a distinct digital processing environment to be executed thereon for a predetermined runtime period, wherein execution of the unique ephemeral machine executable code instance is automatically terminated after the predetermined runtime period; and repeating the deploying for subsequent unique ephemeral machine executable code instances.

Abstract: A system of light emitting diodes and lightguides can produce and distribute light in a luminaire. Two or more lightguides can be mounted adjacent one another so that their edges extend alongside one another. An optic can couple light between the light emitting diodes and the edges of the adjacent lightguides. The optic, which can be another lightguide in some examples, can mix, blend, or homogenize light received from the light emitting diodes and distribute the light among the adjacent lightguides. The optic can mix light emitted from multiple light emitting diodes so that light enters the adjacent lightguides uniformly along the edges of the lightguide, thereby eliminating or reducing any bright spots or visual inconsistencies. The optic can further allocate light uniformly among the adjacent lightguides.

Abstract: Described include various embodiments of an integrated multi-level network appliance and system, and remote management system and method therefor. In one embodiment, the appliance can comprise: two or more hardware-integrated processing engines each operable to implement a corresponding network-related resource associated with a respective network level in accordance with a designated multi-level network architecture; an integrated processor operable to execute the processing engines; one or more integrated data storage resources accessible to the processing engines to implement each corresponding network-related resource; and a trusted single-chip switch having a plurality of hardware ports associated therewith and configured to define in hardware multiple data communication paths embedded therein.

Abstract: Described are various embodiments of a hardware security module. For example, in one embodiment, a hardware security module is described to comprise: two or more hardware ports, each one of which operable to electronically receive given input hardware port-specific cryptographic data thereon to initiate execution of an internal cryptographic process as a function thereof; two or more segregated hardware port-specific storage spaces each operatively linked to a corresponding one of said hardware ports via a corresponding hardware link, and storing respective secured hardware port-specific cryptographic data thereon exclusively retrievable as a function of said given input hardware port-specific cryptographic data corresponding thereto; and a cryptographic engine operable to execute said cryptographic process based on said secured port-specific cryptographic data retrieved from said segregated hardware port-specific storage spaces as a function of said given input port-specific cryptographic data.

Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.

Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A tilt-sensing apparatus for a vehicle, comprising: a controller; and a motion tracker, wherein the controller is configured for communication with the motion tracker and a display, wherein the motion tracker is configured for attachment to a vehicle at a position remote to the display and comprises a first tilt sensor configured to measure a first tilt angle with respect to a first axis and a second tilt sensor configured to measure a second tilt angle with respect to a second axis, wherein the controller is configured to receive data via an output of the motion tracker, said data comprising the first tilt angle and the second tilt angle, and communicate an instruction to the display to display a graphical representation indicative of the first tilt angle and the second tilt angle, and associated method.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.