Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A pneumatic tire having a carcass and a belt reinforcing structure, the belt reinforcing structure comprising: a zigzag belt reinforcing structure formed of a strip of reinforcement cords, the strip of reinforcement cords being inclined at 5 to 30 degrees relative to the centerplane of the tire extending in alternation to turnaround points at each lateral edge, wherein the strip of cords is formed from two different cords made of different materials.

Abstract: A method and a system for transmitting enforceable instructions in a vehicle control (VC) system includes receiving, by a cyclic redundancy check (CRC) calculator, at least one enforceable instruction from vehicle systems. The CRC calculator calculates at least one enforceable instruction CRC based at least partly on the at least one enforceable instruction and transmits the at least one enforceable instruction CRC to a back office server of the VC system and/or an on-board system of a vehicle. Methods for cyclic redundancy check (CRC) hazard mitigation in a vehicle control (VC) system and verifying enforceable instruction data on-board a vehicle are also disclosed.

Abstract: A system includes one or more processors configured to communicatively link a first operator control unit (OCU) disposed off-board a vehicle system with a vehicle control system (VCS) disposed onboard the vehicle system. The vehicle system is formed from first and second vehicles. The VCS is configured to remotely control movement of the second vehicle from the first vehicle, wherein the one or more processors configured to receive a control signal communicated from the first OCU to a communication device that is onboard the first vehicle. The control signal dictates a change in movement operational setting of the second vehicle. The one or more processors configured to direct the communication device to communicate the control signal from the first vehicle to the second vehicle via the VCS, wherein movement of the second vehicle is automatically changed responsive to communicating the control signal from the first vehicle to the second vehicle.

Abstract: Disclosed is a system and method for sorting copper-bearing ore to select portions having a target copper content. The system includes an analysis and selection station including first magnetic resonance analyzer measuring the copper content of input ore and a controlled diverter to divert portions of the input ore to a collection path when the copper content meets or exceeds a predetermined cut-off value. The predetermined cut-off is adjusted by a controller in response to the first magnetic resonance analyzer. A second magnetic resonance analyzer measures the copper content of the ore in a product path. That measurement is fed back to the controller to fine tune the adjusted cut-off value above, up or down, to optimize the yield of ore having the targeted copper content. The system may include a station for sizing the input ore, a station for sizing the output ore, and a station for sizing waste produced by the system.

Abstract: The present invention provides, among other things, compositions and methods for prophylaxis and treatment of autoimmune disease. The present invention is based, in part, on the surprising discovery that a human interleukin-2 mutein activates proliferation of regulatory T cells. In one aspect, the present invention provides compositions and methods for proliferation of regulatory T cells. In another aspect, a human interleukin-2 (IL-2) mutein comprising an amino acid sequence that is at least 90% identical to the wild type IL-2 protein is described, wherein the IL-2 mutein has at least one amino acid substitution selected from a group consisting of T111H, T37Y, E15T, M23L, P34F, E68F and E62A.

Abstract: The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A magnetic connector comprising a male part and a female part, in which said male part comprises a first side and a second side extending from said first side at an oblique angle thereto, in which said male part comprises a first metal portion comprising a first metal surface on said second side, in which said second side comprises a protrusion proud of said first metal surface, in which said female part comprises a third side and a fourth side extending from said third side at an oblique angle thereto, in which said female part comprises a second metal portion comprising a second metal surface on said fourth side, in which said fourth side comprises a slot for receiving said protrusion, in which at least one of said first metal portion and said second metal portion is magnetic and attracts the other.

Abstract: A method includes obtaining unprocessed data from a plurality of sensors mounted on one or more plant equipment, normalizing the unprocessed data to generate normalized data, converting the unprocessed data from a time domain to a frequency domain to generate a frequency domain signal, detecting a performance anomaly associated with the one or more plant equipment based on the normalized data and a change index routine, and determining a primary cause from among one or more causes of the performance anomaly based on the frequency domain signal and one or more rules.

Abstract: A method and a system for transmitting an enforceable instruction in a vehicle control system may include receiving a checksum contained in at least one enforceable instruction. Methods for checksum challenge mitigation in a vehicle control system and verifying enforceable instruction data on-board a vehicle are disclosed.

Abstract: In one aspect, a share data allocation (SDA) computing device is provided. The SDA computing device includes at least one processor in communication with a database. The at least one processor is configured to receive direct-share participant (DSP) request data indicating an amount each DSP is willing to invest and receive interest-based participant (IBP) request data indicating an amount each IBP is willing to invest. The at least one processor is also configured to apply a first mapping algorithm to the DSP request data and apply a second mapping algorithm to the IBP request data. The at least one processor is further configured to calculate a preliminary allocation of a total amount of assets among the DSPs and the IBPs according to results of an apportionment, and direct allocation of the total amount of assets among the DSPs and the IBPs according to results of a join operator.

Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

Abstract: Described herein are improved assisted ventilation interfaces along with methods and uses thereof. The interfaces comprises a hood embodiment with altered design aspects to decrease or even avoid the risk of leakage and potential viral transmittance along with providing other benefits. In one aspect, the patient interface comprises a hood with a free-breathing valve and an integral viral filter. The free-breathing valve and viral filter may be separate to or integral to the exhaust port. In a further embodiment multiple branches may be used from the exhaust port with multiple viral filters. In a further embodiment, an internal pressure gauge may be used. In a further embodiment dual air sources may be used.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: An apparatus for classifying a contrast level of an image is provided. One or more processors execute instructions stored in one or more memory devices which configure the one or more processors to obtain an image from an image source, extract intensity values for each pixel of the obtained image, calculate a probability distribution for the obtained image representing a number of pixels at each unique pixel value, determine, from the calculated probability distribution, a spread value representing a series pixel values including at least a predetermined number of pixels at each pixel value in the series of pixel values and classify the obtained image a member of one of three classes based on the calculated probability distribution and the determined spread value.

Abstract: A method includes receiving first data associated with a first sleep session of a user. The method also includes determining a first set of sleep-related parameters associated with the first sleep session of the user based at least in part on the first data. The method also includes receiving second data associated with a second sleep session of the user. The method also includes determining a second set of sleep-related parameters associated with the second sleep session of the user based at least in part on the second data. The method also includes receiving third data associated with a variable condition. The method also includes causing one or more indications associated with the variable condition and the first sleep session, the second sleep session, or both to be communicated to the user.

Abstract: The invention comprises a method and apparatus for: (1) alternatingly in time inflating and deflating a sealed compartment that includes: a first flexible and deformable seal connected to a pressure control chamber; (2) alternatingly in time pumping a gas into a first chamber and a second chamber separated by a first piston in a first partially sealed cylinder of a double acting kinematic cylinder, the double acting kinematic cylinder further comprising a second partially sealed cylinder, including: a second piston and the pressure control chamber, the pressure control chamber both on a first side of the second piston and within the second partially sealed cylinder; and (3) transferring a force from the first piston to the second piston via a rigid coupler affixed at a first end to the first piston and at a second end to the second piston, such as to alternating inflate and deflate a seal.

Abstract: A robot gripper including: a base section; a first finger connected to the base section by a base section joint and n phalanxes; a second finger connected to the base section by a base section joint and n+m phalanxes, each phalanx of the second finger being connected to an adjacent phalanx by a phalanx joint and the first and second fingers being opposable to one other; wherein n and m are positive integers.