Abstract: Human MAN2A genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of MAN2A are provided.

Abstract: A pivoting telemark binding is provided which includes a toe piece pivotally connected to a base plate and a mechanism for locking the toe piece relative to the base plate to prevent pivoting. An actuator for the locking mechanism is placed at the front end of the binding to be positioned over the ski. Also provided is a ski crampon for use with this binding, as well as a heel lifter device for use with any telemark binding.

Abstract: A notification engine manages subscriptions of applications to data events in a file-sharing environment. A subscription includes a data event recovery time stamp indicating the time when a first change to subscribed data objects occurred of which an application was not aware. When the data event occurs on a computer, the engine finds applications subscribed to that data event and sets the time stamp in the subscriptions for non-local applications to the current time if the data event recovery time stamp is clear. An application that was not notified of the data event that occurred on another computer learns about the data event when it is called back. The application uses a data event recovery time stamp indicated in the callback to issue a query for a current version of subscribed data objects to which data events occurred at or after the time indicated in the time stamp.

Abstract: Methods and systems for secure electronic commerce (eCommerce) transactions having one or more trusted payment hosts where consumers/buyers can register credit card information and/or any payment card information and the corresponding secret keys for the credit card or payment card with the one or more payment hosts are provided. Embodiments of the invention include a method of engaging a purchase order in an online electronic transaction on the spot, where a seller posts and advertises at least one online electronic link embedded in a web-page or in an e-mail provided by a server.

Abstract: For automated text processing, the inventors devised, among other things, an exemplary system that automatically extracts financial events from various unstructured text based sources, such as press releases and news articles. Extracted events, such as mergers & acquisitions, earnings guidance reports, and actual earnings announcements, are represented as structured data records which can be linked, searched, and displayed and used as a basis for controlling accessing to the source documents and other related financial documents for named entities.

Abstract: 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.

Abstract: Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.

Abstract: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.

Abstract: A system that tunes search results is presented. During operation, the system receives content to be searched. The system then iteratively performs the following operations until search results meet specified criteria. The system generates an index of the content based on a set of configuration parameters. Next, the system performs a search against the index to produce the search results. The system then determines whether the search results meet the specified criteria. If the search results do not meet the specified criteria, the system modifies one or more of: the set of configuration parameters; and the content. If the search results meet the specified criteria, the system saves the set of configuration parameters into a configuration file which can be used to generate the index for the content.

Abstract: A method for instance-based sentence boundary determination optimizes a set of criteria based on examples in a corpus, and provides a general domain-independent framework for the task by balancing a comprehensive set of sentence complexity and quality constraints. The characteristics and style of naturally occurring sentences are simulated through the use of semantic grouping and sentence length distribution. The method is parameterized so that it is easily adapts to suit a Natural Language Generation (NLG) system's generation.

Abstract: The following describes a system and methods that provide integrated web-based graphic user interface to manage communications for a variety of WEB-accessible mobile devices, computers, and other consumer electronic devices. The user interface provides a dynamic calendar. The dynamic calendar has the ability to focus the calendar, adjust the size of the calendar, and determine availability of other system users. In addition, the system may automatically organize events scheduled on the calendar.

Abstract: Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided.

Abstract: Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.

Abstract: Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.

Abstract: Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided

Abstract: A method for instance-based sentence boundary determination optimizes a set of criteria based on examples in a corpus, and provides a general domain-independent framework for the task by balancing a comprehensive set of sentence complexity and quality constraints. The characteristics and style of naturally occurring sentences are simulated through the use of semantic grouping and sentence length distribution. The method is parameterized so that it is easily adapts to suit a Natural Language Generation (NLG) system's generation.

Abstract: A sports apparatus for dispensing coating material includes a first housing member manufactured from a first permeable predetermined material and having a first predetermined size and a first predetermined shape. A second housing member is manufactured from a second permeable predetermined material and has a second predetermined size and a second predetermined shape. A first predetermined amount of a third predetermined material fits within such second housing member such that a second predetermined amount of the third predetermined material permeates through such second housing member and such first housing member upon a user touching such first housing member in a predetermined manner.

Abstract: Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.

Abstract: A securing strap arrangement, typically for securing luggage or other items, has a resiliently extensible length portion, and a substantially non-resiliently extensible length portion including an arrangement for varying effective length of the non-resiliently extensible length portion. In a preferred embodiment, the arrangement includes a tensioner grip that stretches the extensible length portion, and a tension grip locator arranged such that the tensioner grip is releasably engageable with the tension grip locater in one of a plurality of location positions that are spaced apart in the longitudinal direction of the securing strap arrangement.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.