Patents by Inventor James T. Palmer

James T. Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of tyrosine kinases and uses thereof
    Patent number: 7625880
    Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 1, 2009
    Assignee: Pharmacyclics, Inc.
    Inventors: Orion D. Jankowski, James T. Palmer, Lee Honigberg
  • Cathepsin cysteine protease inhibitors
    Publication number: 20080188529
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: April 8, 2008
    Publication date: August 7, 2008
    Inventors: Christopher I. Bayly, Cameron Black, Serge Leger, Chun Sing Li, Dan McKay, Christophe Mellon, Jacques Yves Gauthier, Vouy-Linh Truong, Cheuk Lau, Michel Therien, Michael J. Green, Bernard L. Hirschbein, James William Janc, James T. Palmer, Chitra Baskaran
  • Compounds and compositions as cathepsin inhibitors
    Patent number: 7196099
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: March 27, 2007
    Assignees: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals Inc.
    Inventors: Michael Graupe, James T. Palmer, David John Aldous, Sukanthini Thurairatnam
  • Compounds and compositions as cathepsin inhibitors
    Patent number: 7030116
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: April 18, 2006
    Assignees: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, James T. Palmer, John W. Patterson, David J. Aldous, Sukanthini Thurairatnam, Andreas P. Timm, John Link, Jiayao Li
  • Cathepsin cysteine protease inhibitors
    Patent number: 7012075
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 14, 2006
    Assignees: Merck & Co., Inc., Axys Pharmaceuticals, Inc.
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Cathepsin cysteine protease inhibitors
    Publication number: 20040198982
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: August 28, 2003
    Publication date: October 7, 2004
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20040192742
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 30, 2004
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, James T. Palmer, David John Aldous, Sukanthini Thurairatnam
  • Cathepsin cysteine protease inhibitors
    Publication number: 20030232863
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: February 28, 2003
    Publication date: December 18, 2003
    Inventors: Christopher I. Bayly, Cameron Black, Serge Leger, Chun Sing Li, Dan McKay, Christophe Mellon, Jacques Yves Gauthier, Vouy-Linh Truong, Cheuk Lau, Michel Therien, Michael J. Green, Bernard L. Hirschbein, James William Janc, James T. Palmer, Chitra Baskaran
  • Compounds and compositions as protease inhibitors
    Patent number: 6593327
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: July 15, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20030119788
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: September 9, 2002
    Publication date: June 26, 2003
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20030105099
    Abstract: The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: June 26, 2002
    Publication date: June 5, 2003
    Inventors: Michael Graupe, James T. Palmer, John W. Patterson, Stephen D. Pickett, David J. Aldous, Sukanthini Thurairatnam, Andreas P. Timm, Frank Halley, Justine Lai, John Link, Jiayao Li
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20030092634
    Abstract: The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 15, 2003
    Applicant: Axys Pharmaceuticals, Inc.
    Inventors: Ann M. Buysse, Rohan V. Mendonca, James T. Palmer, Zong-Qiang Tian, Shankar Venkatraman
  • Compounds and compositions as protease inhibitors
    Patent number: 6506733
    Abstract: Compounds of the formula: are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy of the disease.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: January 14, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Ann M. Buysse, Rohan V. Mendonca, James T. Palmer, Zong-Qiang Tian, Shankar Venkatraman
  • Compounds and compositions as protease inhibitors
    Patent number: 6476026
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: November 5, 2002
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20020086996
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: December 14, 2001
    Publication date: July 4, 2002
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
    Patent number: 6287840
    Abstract: Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: September 11, 2001
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: James T. Palmer, David Rasnick, Jeffrey Lee Klaus
  • Reversible cysteine protease inhibitors
    Patent number: 6030946
    Abstract: Cysteine protease inhibitors are provided.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: February 29, 2000
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Jeffrey L. Klaus, David Rasnick, James T. Palmer, Elaine Yee-Lin Kuo
  • Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
    Patent number: 5976858
    Abstract: Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: November 2, 1999
    Assignee: Arris Pharmaceuticals
    Inventors: James T. Palmer, David Rasnick, Jeffrey Lee Klaus
  • Reversible protease inhibitors
    Patent number: 5776718
    Abstract: The invention relates to novel reversible protease inhibitors. The inhibitors are specific to cysteine proteases.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: July 7, 1998
    Assignee: Arris Pharmaceutical Corporation
    Inventors: James T. Palmer, David Rasnick, Jeffrey Lee Klaus
  • Process for forming a fluoromethyl ketone
    Patent number: 5344939
    Abstract: The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: September 6, 1994
    Assignee: Prototek, Inc.
    Inventor: James T. Palmer