Patents by Inventor James Thomson

James Thomson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATION OF HUMAN MICROGLIA FROM PLURIPOTENT STEM CELLS
    Publication number: 20260049276
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Application
    Filed: October 1, 2025
    Publication date: February 19, 2026
    Inventors: James Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • Formulations of pegylated arginine deiminase
    Patent number: 12370242
    Abstract: Provided are lyophilized formulations comprising pegylated arginine deiminase (ADI-PEG) and related reconstituted liquid compositions and methods of using the compositions for arginine depletion therapies, including for the treatment of various cancers.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: July 29, 2025
    Assignee: POLARIS GROUP
    Inventors: Bor-Wen Wu, James Thomson, Wen-Chin Tsai
  • INFUSION DEVICE AND METHODS
    Publication number: 20250166814
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Christopher V. REGGIARDO, Namvar KIAIE, James THOMSON
  • GENERATING ALLOGENIC ENDOTHELIAL CELL-SEEDED VASCULAR GRAFTS AND METHODS OF USE THEREOF
    Publication number: 20240335593
    Abstract: Provided herein are allogeneic human endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 10, 2024
    Inventors: James THOMSON, Jue Zhang, John Maufort
  • REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION
    Publication number: 20240319173
    Abstract: The present disclosure provides reagents and methods for identifying compounds that promote arterial endothelial cell differentiation and nitric oxide production therefrom. Pharmaceutical compositions comprising compounds identified thereby are provided as are therapeutic methods using these pharmaceutical compositions for treating neural and cardiovascular diseases and disorders associated with deficient or disrupted nitric oxide production in arterial endothelial cells.
    Type: Application
    Filed: March 21, 2024
    Publication date: September 26, 2024
    Inventors: James Thomson, Jue Zhang
  • Infusion device and methods
    Patent number: 12073941
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: August 27, 2024
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • INFUSION DEVICE AND METHODS
    Publication number: 20240282442
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Application
    Filed: May 2, 2024
    Publication date: August 22, 2024
    Inventors: Christopher V. REGGIARDO, Namvar KIAIE, James THOMSON
  • COMBINATIONAL IMMUNOTHERAPIES USING CAR-M, CAR-NK, CAR-EOS, AND CAR-N CELLS
    Publication number: 20240156963
    Abstract: This disclosure provides genetically engineered immune cells that express an anti-GD2 chimeric antigen receptor, methods of generating these cells, and methods of treating tumors using the genetically engineered cells.
    Type: Application
    Filed: April 18, 2023
    Publication date: May 16, 2024
    Inventors: James Thomson, Jue Zhang, Igor Slukvin, Aditi Majumder, Ho Sun Jung
  • RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
    Publication number: 20240067982
    Abstract: Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from Neisseria and one or more RNA molecules in order to direct the Cas9 protein to bind to and optionally cleave or nick a target sequence.
    Type: Application
    Filed: November 23, 2022
    Publication date: February 29, 2024
    Inventors: Erik J. Sontheimer, Yan Zhang, Alfonzo Mondragon, Rakhi Rajan, James Thomson, Zhonggang Hou
  • Infusion devices and methods
    Patent number: 11837358
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: December 5, 2023
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • DERIVATION OF HEPATOCYTES AND HEMATOPOIETIC PROGENITORS FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20230113074
    Abstract: This disclosure relates generally to methods for generating small hepatocyte progenitor cells (SHPCs) and hematopoietic progenitor cells (HPCs) from human embryonic stem cells, and hematopoietic progenitor cells from primary human endothelial cells and cell lines populations of small hepatocyte progenitor cells and hematopoietic progenitor cells, and uses thereof.
    Type: Application
    Filed: October 11, 2022
    Publication date: April 13, 2023
    Inventors: Srikumar Sengupta, James Thomson
  • INFUSION DEVICE AND METHODS
    Publication number: 20230064839
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Application
    Filed: November 10, 2022
    Publication date: March 2, 2023
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • Infusion devices and methods
    Patent number: 11508476
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: November 22, 2022
    Assignee: Abbott Diabetes Care, Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPORGRAMMING
    Publication number: 20220010331
    Abstract: Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed.
    Type: Application
    Filed: June 21, 2021
    Publication date: January 13, 2022
    Inventors: James Thomson, Junying Yu
  • Infusion Devices and Methods
    Publication number: 20220013224
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Application
    Filed: June 22, 2021
    Publication date: January 13, 2022
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • Infusion Devices and Methods
    Publication number: 20210398663
    Abstract: Medical devices, systems, and methods related thereto a glucose monitoring system having a first display unit in data communication with a skin-mounted assembly, the skin-mounted assembly including an in vivo sensor and a transmitter. The first display unit and a second display unit are in data communication with a data management system. The first display unit comprises memory that grants a first user first access level rights and the second display unit comprises memory that grants a second individual second access level rights.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • Infusion devices and methods
    Patent number: 11043300
    Abstract: Medical devices, systems, and methods related thereto having hierarchical restrictive access schemes are provided. Such medical devices, systems, and methods may include an in vitro analyte monitoring device, an in vivo analyte monitoring device, and/or a drug infusion device having, among other features, hierarchical permission schemes allowing individual access levels thereto.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: June 22, 2021
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPROGRAMMING
    Publication number: 20190330654
    Abstract: Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed.
    Type: Application
    Filed: December 4, 2018
    Publication date: October 31, 2019
    Inventors: James Thomson, Junying Yu
  • Infusion Devices and Methods
    Publication number: 20180308579
    Abstract: Medical devices, systems, and methods related thereto having hierarchical restrictive access schemes are provided. Such medical devices, systems, and methods may include an in vitro analyte monitoring device, an in vivo analyte monitoring device, and/or a drug infusion device having, among other features, hierarchical permission schemes allowing individual access levels thereto.
    Type: Application
    Filed: June 25, 2018
    Publication date: October 25, 2018
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Christopher V. Reggiardo, Namvar Kiaie, James Thomson
  • FORMULATIONS OF PEGYLATED ARGININE DEIMINASE
    Publication number: 20180296652
    Abstract: Provided are lyophilized formulations comprising pegylated arginine deiminase (ADI-PEG) and related reconstituted liquid compositions and methods of using the compositions for arginine depletion therapies, including for the treatment of various cancers.
    Type: Application
    Filed: November 2, 2017
    Publication date: October 18, 2018
    Inventors: Bor-Wen Wu, James Thomson, Wen-Chin Tsai