Patents by Inventor James W. Davis
James W. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140364422Abstract: The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.Type: ApplicationFiled: August 25, 2014Publication date: December 11, 2014Inventors: David L. Meadows, Howard Allen Ketelson, Jang-Shing Chiou, James W. Davis
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Patent number: 8846641Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.Type: GrantFiled: May 13, 2013Date of Patent: September 30, 2014Assignee: Alcon Research, Ltd.Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
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Publication number: 20140161760Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.Type: ApplicationFiled: February 14, 2014Publication date: June 12, 2014Applicant: Alcon Research, Ltd.Inventors: Howard Allen Ketelson, David L. Meadows, James W. Davis
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Patent number: 8751095Abstract: A vehicle includes a first control configured to operate the vehicle from a first operator position facing a front of the vehicle and a second control configured to operate the vehicle from a second operator position facing a rear of the vehicle. The vehicle further includes a processor configured to monitor for an operator presence in the first operator position or the second operator position and receive a vehicle operating request, wherein the operator presence is monitored independent of receiving the vehicle operating request. The processor is further configured to enable either the first control or the second control and select a vehicle operating parameter associated with the vehicle operating request, wherein the vehicle operating parameter varies according to which control is enabled.Type: GrantFiled: February 11, 2013Date of Patent: June 10, 2014Assignee: NMHG Oregon, LLCInventors: Christopher J. Goodwin, Brian R. Crowell, Timothy L. Rose, James W. Davis, Gerald A. Johnson, Kevin J. McGoldrick, Michael Curry
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Patent number: 8685945Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.Type: GrantFiled: November 22, 2011Date of Patent: April 1, 2014Assignee: Alcon Research, Ltd.Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
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Publication number: 20130330430Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.Type: ApplicationFiled: August 14, 2013Publication date: December 12, 2013Applicant: Alcon Research, Ltd.Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows, John C. Baker
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Publication number: 20130296264Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.Type: ApplicationFiled: May 3, 2013Publication date: November 7, 2013Applicant: ALCON RESEARCH, LTD.Inventors: James W. Davis, Howard Allen Ketelson, Elaine E. Campbell, David L. Meadows, Rekha Rangarajan
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Publication number: 20130244971Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.Type: ApplicationFiled: May 13, 2013Publication date: September 19, 2013Applicant: ALCON RESEARCH, LTD.Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
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Patent number: 8536325Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.Type: GrantFiled: February 14, 2012Date of Patent: September 17, 2013Assignee: Alcon Research, Ltd.Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows, John C. Baker
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Patent number: 8392049Abstract: A vehicle includes a first control configured to operate the vehicle from a first operator position facing a front of the vehicle and a second control configured to operate the vehicle from a second operator position facing a rear of the vehicle. The vehicle further includes a processor configured to monitor for an operator presence in the first operator position or the second operator position and receive a vehicle operating request, wherein the operator presence is monitored independent of receiving the vehicle operating request. The processor is further configured to enable either the first control or the second control and select a vehicle operating parameter associated with the vehicle operating request, wherein the vehicle operating parameter varies according to which control is enabled.Type: GrantFiled: May 12, 2009Date of Patent: March 5, 2013Assignee: NMHG Oregon, LLCInventors: Christopher J. Goodwin, Brian R. Crowell, Timothy L. Rose, James W. Davis, Gerald A Johnson, Kevin J. McGoldrick, Michael Curry
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Publication number: 20120142630Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.Type: ApplicationFiled: February 14, 2012Publication date: June 7, 2012Applicant: ALCON RESEARCH, LTD.Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows, John C. Baker
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Publication number: 20120070402Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.Type: ApplicationFiled: November 22, 2011Publication date: March 22, 2012Applicant: ALCON RESEARCH, LTD.Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
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Publication number: 20110300019Abstract: The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful, for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention.Type: ApplicationFiled: June 2, 2011Publication date: December 8, 2011Applicant: Alcon Research, LtdInventors: James W. Davis, Howard Allen Ketelson
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Publication number: 20110275593Abstract: The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.Type: ApplicationFiled: May 4, 2011Publication date: November 10, 2011Applicant: ALCON RESEARCH, LTD.Inventors: Howard Allen Ketelson, James W. Davis, David L. Meadows
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Patent number: 8022663Abstract: A system for capturing regenerative energy includes a battery configured to provide power for a traction motor and other operations of a vehicle and a capacitor connected to the battery. An auxiliary motor is configured to operate as a generator during a regenerative energy operation. The system further includes a controller configured to direct the regenerative energy to the capacitor during the regenerative energy operation and discharge the capacitor to provide power to the traction motor or for the other operations of the vehicle.Type: GrantFiled: May 21, 2008Date of Patent: September 20, 2011Assignee: NMHG Oregon, LLCInventors: James W. Davis, Kevin J. McGoldrick, Alan H. Fitzsimmons, Robert M. Neil, John Rowley
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Publication number: 20110151017Abstract: The present invention relates to ophthalmic solutions with antimicrobial activity. The solutions have an antimicrobial compound such as hydrogen peroxide and a boron compound. In one embodiment, the solutions contain a boron compound such as sodium borate that provides antimicrobial activity in addition to that of hydrogen peroxide, particularly during periods following disinfection and neutralization of such solutions. This additional activity reduces the likelihood of microbial growth in contact lens disinfection applications that neutralize hydrogen peroxide.Type: ApplicationFiled: December 17, 2010Publication date: June 23, 2011Applicant: ALCON RESEARCH, LTD.Inventors: Howard Allen Ketelson, Roya Nicole Borazjani, Nissanke L. Dassanayake, James W. Davis, Thomas Christopher Carey, John C. Baker
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Publication number: 20110008276Abstract: The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.Type: ApplicationFiled: July 7, 2010Publication date: January 13, 2011Applicant: ALCON RESEARCH, LTD.Inventors: James W. Davis, Howard Allen Ketelson, David L. Meadows
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Publication number: 20100196415Abstract: The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.Type: ApplicationFiled: February 5, 2010Publication date: August 5, 2010Applicant: ALCON RESEARCH, LTD.Inventors: James W. DAVIS, Howard Allen KETELSON, David L. MEADOWS, John C. BAKER
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Publication number: 20090270345Abstract: The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.Type: ApplicationFiled: April 24, 2009Publication date: October 29, 2009Applicant: ALCON RESEARCH, LTD.Inventors: Howard Allen KETELSON, James W. DAVIS, David L. MEADOWS
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Publication number: 20090222167Abstract: A vehicle includes a first control configured to operate the vehicle from a first operator position facing a front of the vehicle and a second control configured to operate the vehicle from a second operator position facing a rear of the vehicle. The vehicle further includes a processor configured to monitor for an operator presence in the first operator position or the second operator position and receive a vehicle operating request, wherein the operator presence is monitored independent of receiving the vehicle operating request. The processor is further configured to enable either the first control or the second control and select a vehicle operating parameter associated with the vehicle operating request, wherein the vehicle operating parameter varies according to which control is enabled.Type: ApplicationFiled: May 12, 2009Publication date: September 3, 2009Applicant: NMHG OREGON, LLCInventors: Christopher J. Goodwin, Brian R. Crowell, Timothy L. Rose, James W. Davis, Gerald A. Johnson, Kevin J. McGoldrick