Abstract: Prosthetic valve preparation assemblies and associated methods are disclosed herein. A crimper assembly can include a first crimp stop and a second crimp stop that define respective ranges of motion of an actuator handle. A method of mounting an implantable prosthetic valve to a valve delivery apparatus can include inserting a balloon catheter within the implantable prosthetic valve, partially crimping an annular frame of the implantable prosthetic valve, positioning a crimp alignment tool in an alignment configuration relative to the valve delivery apparatus, positioning the implantable prosthetic valve to engage the crimp alignment tool, and fully crimping the annular frame.

Abstract: A patient interface assembly has a patient interface and a securement system for the patient interface and/or patient interface tubing. The patient interface has a body and at least one nasal prong extending from the body. The at least one nasal prong has a gas inlet for fluid communication with a supply of breathable gas, and a gas outlet configured to direct a flow of gas towards a nare of the user's nose. The at least one nasal prong further includes an exterior surface, at least a portion of the exterior surface is a sealing surface configured to seal the nare of the user's nose. The securement system has a two-part releasable attachment or connection arrangement, the arrangement comprising a first patch and a second patch.

Abstract: An illumination assembly is configured for providing auxiliary illumination for use with a vehicle. The illumination assembly includes a housing. The housing defines an interior with an open face. A frame is provided at the open face. A lens cover is coupled to the open face and at least partially overlies the frame. An illuminator is at least partially formed by the frame and the lens cover with a light source configured to emit a trajectory of light.

Abstract: A device which provides a measure of the compliance of a vessel wall based on a change in pressure, which causes the vessel to distend. The device comprises a coil and capacitor, forming a tank circuit. The coil is expandable and positioned along a portion of the vessel so that when the portion of the vessel expands or contracts, the coil will also expand or contract, changing the area inside the coil. This change in area alters the coil inductance, and therefore the resonant frequency of the tank circuit, which can be detected externally.

Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.

Abstract: In embodiments, methods and systems for order management and processing based on a distributed commerce platform are provided. A distributed commerce platform supports end-to-end integrated product publication, order-management and payment services. In particular, the distributed commerce platform supports components based on Application Programming Interfaces (API) that standardize the implementation of a distributed commerce solution or configuration of off-site buying experiences. Using the distributed commerce platform, merchants can concurrently offer, sell, and process orders for products through a plurality of different affiliate channels. The distributed commerce platform can also be implemented as a federated portal from which a merchant can identify affiliate channels to publish product objects, access the plurality of affiliate channels and define configurations for processing objects of the merchant's distributed commerce solution.

Abstract: A powder including a plurality of particulates, each particulate including a soft magnetic metallic core coated with a continuous dielectric coating having a thickness selected from a range of 100 nanometers to 100 micrometers. The particulates have a mean particle size selected from a range of 100 nanometers to 250 micrometers. Methods for forming the powder are disclosed. A soft magnetic composite component includes a soft magnetic material in a dielectric matrix, wherein (i) the soft magnetic material comprises a plurality of particulates comprising metallic cores, (ii) each metallic core is coated by a continuous dielectric coating covering >90% of a surface area of the metallic core, (iii) the metallic cores are electrically isolated from each other, and (iv) the dielectric coatings of adjacent metallic cores are consolidated together. Methods for formation of the soft magnetic component by additive manufacturing and hot isostatic pressing are disclosed.

Abstract: An illumination assembly is configured for providing auxiliary illumination for use with a vehicle. The illumination assembly includes a housing. The housing defines an interior with an open face. A frame is provided at the open face. A lens cover is coupled to the open face and at least partially overlies the frame. An illuminator is at least partially formed by the frame and the lens cover with a light source configured to emit a trajectory of light.

Abstract: A vegetable slicing shield includes a root, a u-shaped handle, and a plurality of tines. The root is medially disposed between the u-shaped handle and the tines. The u-shaped handle is coupled with the root at opposing lateral regions of a first side of the root. The plurality of tines have first ends coupled with a second side of the root and extending outward from the root to second ends which form a row spaced apart points. Open slots are defined between adjacent tines of the plurality of tines. A subset of the tines are shaped between their first ends and their second ends to form slices of a containment basket which is curved in three-dimensions.

Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.

Abstract: A vehicle can include various sensors to detect objects in an environment. In some cases, the object may be within a planned path of travel of the vehicle. In these cases, leaving the planned path may be dangerous to the passengers so the vehicle may, based on dimensions of the object, dimensions of the vehicle, and semantic information of the object, determine operational parameters associate with passing the object while maintaining a position within the planned path, if possible.

Abstract: A control system provides automated control of gas washout of a patient interface, such as a mask or nasal prongs. A gas washout vent assembly of the system may include a variable exhaust area such as one defined by overlapping apertures of the assembly or a conduit having a variable gas passage channel. The vent assembly may be formed by nested structures, such as conic or cylindrical members, each having an opening of the overlapping apertures. The vent assembly may be attached substantially near or included with the patient interface. An actuator of the assembly, such as a solenoid or voice coil, manipulates an aperture of the vent assembly. The actuator may be configured for control by a controller to change the exhaust area of the vent assembly based on various methodologies including, for example, sleep detection, disordered breathing event detection, rebreathing volume calculation and/or leak detection.

Abstract: Head-mounted augmented reality (AR) devices can track pose of a wearer's head to provide a three-dimensional virtual representation of objects in the wearer's environment. An electromagnetic (EM) tracking system can track head or body pose. A handheld user input device can include an EM emitter that generates an EM field, and the head-mounted AR device can include an EM sensor that senses the EM field. EM information from the sensor can be analyzed to determine location and/or orientation of the sensor and thereby the wearer's pose. The EM emitter and sensor may utilize time division multiplexing (TDM) or dynamic frequency tuning to operate at multiple frequencies. Voltage gain control may be implemented in the transmitter, rather than the sensor, allowing smaller and lighter weight sensor designs. The EM sensor can implement noise cancellation to reduce the level of EM interference generated by nearby audio speakers.

Abstract: A process for removing carbon dioxide from a material includes introducing the material onto a first segment of a conveyance system comprising the first segment and a second segment that is physically separated from the first segment, heating the material at the first segment for a first time using a first infrared emitter, conveying the material from the first segment to the second segment, and heating the material at the second segment for a second time using a second infrared emitter. The carbon dioxide removed from the material can be captured by a vacuum pump and stored, and the vacuum pump can maintain a partial pressure for the process. The process can be used to create lime and clinker with minimal CO2 emissions and to remove CO2 that is stored in various materials.

Abstract: A breathing circuit for use in respiratory therapy includes an inspiratory tube and an expiratory tube. The inspiratory tube of the breathing circuit has a smooth bore. The expiratory tube of the breathing circuit is corrugated. Preferably, the expiratory tube is vapor permeable. Using the combination of a smooth bore inspiratory tube with a corrugated expiratory tube has the unexpected result of improving the performance of the breathing circuit and its components.

Abstract: The present disclosure relates a method of 3-dimensional printing a printed part. The method comprises printing an inkjet dopant composition at selected locations on a layer of build material comprising polymer particles. The inkjet dopant composition comprises a dopant dispersed or dissolved in a liquid carrier. Polymer particles at selected areas of the layer of build material are then fused to form a fused polymer layer comprising the dopant. The selected areas of the layer of build material include areas of the layer of build material that have not been printed with the inkjet dopant composition.

Abstract: A method of manufacturing a composite (e.g. fibre-reinforced polymer) connector comprises: manufacturing a tubular hub portion which extends substantially parallel to a central axis C, the hub portion comprising a thermoplastic polymer reinforced with continuous, circumferentially-oriented fibre reinforcement; placing the hub portion into a mould featuring at least one cavity; and introducing polymer into the mould so as to fill the at least one cavity to form a flange portion around the hub portion.

Abstract: A chiller includes a housing, a main chiller control board positioned in the housing, a communications board positioned in the housing, a first communication channel between the main chiller control board and the communications board, and a second communication channel between the main chiller control board and the communications board. The second communications channel provides higher bandwidth communications than the first communication channel.

Abstract: A chiller includes cooling components configured to chill a fluid, a housing coupled to the cooling components, an antenna positioned at an exterior of the housing, a circuit board positioned in the housing and comprising a plurality of mounting points, an antenna mount fastened to the plurality of mounting points such that the antenna mount is disposed over a portion of the circuit board, and a cable extending from the antenna mount to the antenna via a hole in the housing.