Abstract: This disclosure describes a distributed automated mobile vehicle (“automated mobile vehicle”) system for autonomously delivering orders of items to various delivery locations and/or autonomously returning items to a return location. In some implementations, each user may own or be assigned their own automated mobile vehicle that is associated with the user and an automated mobile vehicle control system maintained by the user. When the user orders an item, the user owned or controlled automated mobile vehicle navigates to a materials handling facility, retrieves the ordered item and delivers it to the user.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: Surgical staplers and methods of their use are provided. In one embodiment, a surgical stapler includes a tubular shaft having a proximal end and a distal end, a handle extending from the proximal end of the tubular shaft, a head assembly extending from the distal end of the tubular shaft, and an insertion guide configured to extend through the head assembly. The insertion guide includes an expandable member configured to move between a collapsed configuration and an expanded configuration and a camera configured to be positioned at least partially within the expandable member.

Abstract: A humidification system for delivering humidified gases to a user can include a heater base, humidification chamber having an inlet, outlet, and associated fluid conduit, and breathing circuit including a supply conduit, inspiratory conduit, and optional expiratory conduit. The humidification system can include various features to help make set-up less difficult and time-consuming. For example, the supply conduit, inspiratory conduit, and optional expiratory conduit can be coupled into a one-piece circuit to aid set-up. Various components can be color-coded and can have corresponding structures to indicate which components should be connected to one another during set-up. Such features can also help make the set-up process more intuitive for an operator, which can reduce the need for specialized training and reduce the number of potential errors.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Described are methods and devices for modulating the brain activity of a person using stimulation pulses, where the pulse amplitude is variable and approximates a sine-wave. This results in a stimulation pulse that comprises energy at multiple frequencies.

Abstract: A system for heat treating a part includes an oven chamber, a first infrared (IR) emitter configured to deliver a first amount of IR energy to a first region of the part, a second IR emitter configured to deliver a second amount of IR energy different from the first amount of energy to a second region of the part, and a receiver with an outer surface configured to contact a second surface of the part and shield the second surface of the part from infrared radiation. The part can be heat treated by delivering different amounts of IR energy to the first and second regions of the part. The system can be used to heat treat different thicknesses of a part without overheating a thinner region, or to apply different heat treatments to the different regions.

Abstract: Examples of the disclosure include a method comprising receiving information-technology-device information indicative of IT equipment and including information-technology-device-location information and temperature information; determining, based on the information-technology-device information, an IT-equipment-cooling assessment; receiving cooling-unit information indicative of air output by the IT equipment to the cooling units and/or provided by the cooling units to the IT equipment; determining, based on the cooling-unit information, a cooling-airflow-return effectiveness indicative of how effectively the cooling units capture air output by the IT equipment and/or a cooling-airflow-supply effectiveness indicative of how effectively the cooling units provide air to the IT equipment; and displaying a simulation display depicting the IT equipment, an effectiveness indicator for the cooling-airflow-return effectiveness and/or the cooling-airflow-supply effectiveness, and a respective IT indicator for each IT-

Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.

Abstract: A shell extractor tool for removing a jammed ammunition shell from a firearm comprises a handle portion and a shaft portion. The shaft portion is adapted to be inserted through a firearm port and terminates at a proximal end and wherein the proximal end is angled relative to a remainder of the shaft portion to permit engagement of the jammed ammunition shell in a chamber of a firearm. The handle portion is adapted to be grasped by a user and to apply leverage to the jammed ammunition shell, to allow removal of the ammunition shell from the firearm with the shell extractor tool. The shell extractor tool may be provided with a sheath to provide a shell extractor tool kit. The sheath comprises a first structural portion and a second structural portion. The first structural portion and second structural portion are secured together to form a pocket to receive and reversibly secure the extractor tool. The sheath may optionally comprise a third structural portion.

Abstract: Methods and systems are provided for facilitating generation and utilization of causal-based models. In embodiments described herein, a set of events comprising touchpoints resulting in a conversion are obtained. A direct attribution indicating credit for an event contribution to the conversion is determined. An adjusted attribution for the event based on the direct attribution for the event augmented with an indirect attribution for the event is determined. The indirect attribution can be identified based on the event causing a subsequent event of the set of events to result in the conversion. Thereafter, the adjusted attribution for the event is provided to indicate an extent of credit assigned to the event for causing the corresponding conversion.

Abstract: A method for scoring and reporting electroencephalogram (EEG) data for use in transcranial magnetic stimulation (TMS) therapy. The method may include removing artifacts from the EEG data and determining EEG metrics from the EEG data. The method may further include determining a Brain Synchrony Index from the EEG metrics by applying a predetermined transfer function to the EEG metrics, and reporting the Brain Synchrony Index graphically.

Abstract: Described herein are improved thermoplastic composites, which demonstrate excellent physical properties, such as yield strength, ultimate tensile strength, toughness, elongation, and, optionally, superior tunable biodegradability when compared to known thermoplastics. The composite comprises minimally a thermoplastic polymer, at least one phenolic compound, and, optionally, a filler.

Abstract: This disclosure relates to a system and method for playing a beer dice game in an aquatic environment. The system can comprise a floatable gaming table. The floatable gaming table can comprise a table top, a buoyant layer, and a cup holder. The table top can comprise a playing surface. The playing surface can comprise a line that divides the playing surface into a first territory and a second territory. The buoyant layer can have a density sufficiently low enough such that the playing surface can float above a surface of water when the floating gaming table is placed within the water. The cup holder can be at each corner of the tabletop.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: This disclosure pertains to the use of black liquors from kraft pulp mills as a source of catalysts for the thermochemical conversion of organic matter feedstocks to bio oils.

Abstract: Systems and methods for joint document signing are described. According to one aspect, a method for joint document signing includes establishing a live communication session including a plurality of users. In some cases, the plurality of users correspond to a set of signers of a document. The method further includes initiating a signing process during the live communication session, receiving a signature for the document from each of the plurality of users during the live communication session based on the signing process, and generating a signed document including the signature from each of the plurality of users.