Abstract: The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: The invention relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof, and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof; and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof which inhibits a component of the chemokine receptor pathway other than the chemokine receptor. Oral sustained release pharmaceutical compositions comprising the pharmaceutical composition, as well as injectable sustained release pharmaceutical compositions comprising the pharmaceutical composition are described. The invention further relates to tablets, capsules, injectable suspensions, and compositions for pulmonary or nasal delivery comprising the pharmaceutical composition.

Abstract: A composite shaft with an end fitting mounted on one end of said shaft and a preload structure arranged to provide a biasing force to bias the composite shaft against the end fitting. The end fitting has a first interface surface, the first interface surface being tapered at an angle to the shaft axis and the shaft has a second interface surface for engagement with the first interface surface and is tapered at an angle to the shaft axis, the second interface surface extending axially from a first end to a second end, the shaft being thicker at the second end than at the first end. The shaft has a third interface surface and the preload structure has a fourth interface surface and the contact pressure of the third interface against the fourth interface increases from the first end of the shaft to the second end of the shaft.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: An insulating device can include a body assembly and a lid assembly where an insulating layer and aerogel structure is connected to both the body assembly and the lid assembly. An aperture with a closure is formed between the body assembly and lid assembly to form a storage compartment. The insulating layer and aerogel structure on the lid assembly may extend beyond the closure when the closure is sealed. The insulating layer and aerogel structure on the lid assembly may have an insulating ring and aerogel ring structure that has an increased thickness around its perimeter.

Abstract: A 3-dimensional printed part can include a part body including a first matrix of fusing agent and thermoplastic polymer powder, a security feature including a second matrix of fusing agent, thermoplastic polymer powder, and photoluminescent agent, and a masking feature including a third matrix of fusing agent and thermoplastic polymer powder. The security feature can be positioned beneath and visible through the masking feature upon photoluminescent emission of the security feature.

Abstract: The invention provides an optoelectronic device comprising a photoactive region, which photoactive region comprises: an n-type region comprising at least one n-type layer; a p-type region comprising at least one p-type layer; and, disposed between the n-type region and the p-type region: a layer of a perovskite semiconductor without open porosity. The perovskite semiconductor is generally light-absorbing. In some embodiments, disposed between the n-type region and the p-type region is: (i) a first layer which comprises a scaffold material, which is typically porous, and a perovskite semiconductor, which is typically disposed in pores of the scaffold material; and (ii) a capping layer disposed on said first layer, which capping layer is said layer of a perovskite semiconductor without open porosity, wherein the perovskite semiconductor in the capping layer is in contact with the perovskite semiconductor in the first layer.

Abstract: The disclosure relates to methods of fabricating of ceramic structures, and more particularly to methods of fabricating ceramic structures having profiled surfaces and more particularly to methods of fabrication of ceramic mirror blanks. In one embodiment, a method of forming a shaped ceramic article, includes: forming, via one of a cold-pressing process or pressure casting process, a green ceramic article comprising a first surface, an opposing second surface and at least one high aspect ratio feature shaped into at least one surface; heating the green featured ceramic part to form a debound featured ceramic part; and densifying the debound featured ceramic part via one of a pressureless sintering process or a hot-pressing process.

Abstract: A trajectory estimate of a wheeled vehicle can be determined based at least in part on determining a wheel angle associated with the vehicle. In some examples, at least a portion of the image associated with the wheeled vehicle may be input into a machine-learned model that is trained to classify and/or regress wheel directions of wheeled vehicles. The machine-learned model may output a predicted wheel direction. The wheel direction and/or additional or historical sensor data may be used to estimate a trajectory of the wheeled vehicle. The predicted trajectory of the object can then be used to generate and refine an autonomous vehicle's trajectory as the autonomous vehicle proceeds through the environment.

Abstract: A multi-aperture free-space optical communications receiver comprises a plurality of telescopes each having a clear objective aperture with a diameter between 50 mm and 250 mm and arranged for receiving light collectively from an optical communications light source. A coherent combiner unit is configured for coherently combining the collectively received light to produce a combined optical signal therewith. Each telescope is arranged in association with, respectively, a wavefront detector to determine a wavefront of said received light directed to it by the respective telescope, a steerable reflector unit including a deformable mirror controllable to deform according to said determined wavefront such that said received light is reflected by the deformable mirror with a modified wavefront, and an optical signal receiver comprising a single-mode optical fibre.

Abstract: Head-mounted augmented reality (AR) devices can track pose of a wearer's head to provide a three-dimensional virtual representation of objects in the wearer's environment. An electromagnetic (EM) tracking system can track head or body pose. A handheld user input device can include an EM emitter that generates an EM field, and the head-mounted AR device can include an EM sensor that senses the EM field. EM information from the sensor can be analyzed to determine location and/or orientation of the sensor and thereby the wearer's pose. The EM emitter and sensor may utilize time division multiplexing (TDM) or dynamic frequency tuning to operate at multiple frequencies. Voltage gain control may be implemented in the transmitter, rather than the sensor, allowing smaller and lighter weight sensor designs. The EM sensor can implement noise cancellation to reduce the level of EM interference generated by nearby audio speakers.

Abstract: A method includes receiving, by a question answering system having a confidence threshold, plural questions from one or more user devices. The method includes processing each one of the questions by: generating an answer to the one of the questions; determining a confidence score of the answer; in response to determining the confidence score is greater than the confidence threshold, increasing the confidence threshold and returning the answer to the user device that generated the one of the questions; and in response to determining the confidence score is less than the confidence threshold, decreasing the confidence threshold and not returning the answer to the user device that generated the one of the questions. The increasing the confidence threshold and the decreasing the confidence threshold are performed such that the question answering system returns answers for the plural questions at a frequency that approximates a pre-defined target answering frequency.

Abstract: The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of making and using these anti-PDL1 antibodies and anti-PDL1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An anvil roll is configured to operatively engage with a tooling agent. The anvil includes an outer surface, an opposing surface opposite the outer surface and an inner surface. One or more spring elements are disposed between the opposing surface and the inner surface. The springs provide a compliance to the anvil.

Abstract: System and methods for managing dynamic electronic documents on a private distributed ledger comprise establishing a dynamic electronic document comprising a first state object, wherein the state object references a prior approved first transaction; proposing a second transaction comprising as an input the first state object and as an output a transaction command to alter the state object as well as what parameters are required to validate the second transaction; validating the proposed second transaction; and updating the state object on a private distributed ledger to reference the second transaction.

Abstract: A quick release corrosion coupon holder system comprising a shaft and a clip configured to pivot between open and closed positions to securely hold an end of a corrosion coupon. Preferably, no nuts, bolts, or removable parts are required to install or remove a coupon from the holder. Preferably a spring is disposed between the shaft and clip with one or more attached legs or a separate pin configured to secure the clip to the shaft and act as a fulcrum. An optional inwardly extending projection may be inserted through an aperture on the coupon. An optional spacer creates a gap between the shaft and clip to accommodate the thickness of a coupon. Preferably a lip and shoulder pair on the clip and an opposing lip and shoulder pair on the shaft contact front and back surfaces of the coupon, limiting contact surface area between the holder and coupon.

Abstract: A receiver is formed as the physical inverse or relief of at least a portion of a machined part or casting. The receiver has accommodations for sensor systems that monitor the temperature of the part during a radiant heating process which is placed on top of the casting receiver to move through the radiant heating process.