Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: Methods and systems for processing real-time event data by aggregating event data over various time windows and storing aggregate event data records containing the aggregated data. The method may include receiving event data at a current time, determining that the event data relates to a time prior to the beginning of a current time window, and identifying, based on the time, one or more stored aggregate event records each associated with a respective previous time window. The method may include creating, for each of the identified one or more stored aggregate event records, a new aggregate event record containing updated aggregate event data adjusted by the event data, and storing each new aggregate event record in association with its respective previous time window and a creation timestamp reflecting the current time.

Abstract: Methods and apparatus for thermal management in data storage devices are provided. One such data storage device includes a non-volatile memory (NVM), at least one ambient temperature sensor configured to detect an ambient temperature of the data storage device, at least one component temperature sensor configured to detect one or more component temperatures of one or more components of the data storage device, and a processor coupled to the NVM, the at least one ambient temperature sensor, and the at least one component temperature sensor. The processor is configured to determine a composite temperature of the data storage device based on the one or more component temperatures and the ambient temperature. The processor is further configured to determine whether the composite temperature exceeds a threshold and perform a thermal management operation if the composite temperature exceeds the threshold.

Abstract: Provided herein are titanium alloys that can achieve a combination of high strength and high toughness or elongation, and a method to produce the alloys. By tolerating iron, oxygen, and other incidental elements and impurities, the alloys enable the use of lower quality scrap as raw materials. The alloys are castable and can form ?-phase laths in a basketweave morphology by a commercially feasible heat treatment that does not require hot-working or rapid cooling rates. The alloys comprise, by weight, about 3.0% to about 6.0% aluminum, 0% to about 1.5% tin, about 2.0% to about 4.0% vanadium, about 0.5% to about 4.5% molybdenum, about 1.0% to about 2.5% chromium, about 0.20% to about 0.55% iron, 0% to about 0.35% oxygen, 0% to about 0.007% boron, and 0% to about 0.60% other incidental elements and impurities, the balance of weight percent comprising titanium. There exists an unmet need to produce titanium alloys for use in aerospace applications which have a refined equiaxed grain structure.

Abstract: Example furnaces and methods related thereto include a burner box including at least one burner configured to combust a fuel/air mixture. In addition, the furnace includes a first blower including an inlet nozzle having an air inlet and fuel inlet. The inlet nozzle is configured such that operation of the first blower is to pull air and fuel into the inlet nozzle to produce the fuel/air mixture at a fuel/air ratio that is configured to produce flue products having less than 14 Nano-grams per Joule of nitrogen oxides when combusted. Operation of the first blower is configured to push the fuel/air mixture into the burner box. Further, the furnace includes a heat exchanger assembly fluidly coupled to the burner box through a vestibule, and a second blower configured to pull the flue products through the heat exchanger assembly.

Abstract: Systems and methods for generating min-increment counting bloom filters to determine count and frequency of device identifiers and attributes in a networking environment are disclosed. The system can maintain a set of data records including device identifiers and attributes associated with device in a network. The system can generate a vector comprising coordinates corresponding to counter registers. The system can identify hash functions to update a counting bloom filter. The system can hash the data records to extract index values pointing to a set of counter registers. The system can increment the positions in the min-increment counting bloom filter corresponding to the minimum values of the counter registers. The system can obtain an aggregated public key comprising a public key. The system can encrypt the counter registers using the aggregated shared key to generate an encrypted vector. The system can transmit the encrypted vector to a networked worker computing device.

Abstract: A rotating magnet heater for metal products, such as aluminum strip, can include permanent magnet rotors arranged above and below a moving metal strip to induce moving or time varying magnetic fields through the metal strip. The changing magnetic fields can create currents (e.g., eddy currents) within the metal strip, thus heating the metal strip. A magnetic rotor set can include a pair of matched magnetic rotors on opposite sides of a metal strip that rotate at the same speed. Each magnetic rotor of a set can be positioned equidistance from the metal strip to avoid pulling the metal strip away from the passline. A downstream magnetic rotor set can be used in close proximity to an upstream magnetic rotor set to offset tension induced by the upstream magnetic rotor set.

Abstract: This disclosure describes techniques for authenticating one or more devices of a user in association with cloud computing services. The techniques include generating credential portions. The credential portions may be used in a signing protocol between one of the user devices and a cloud authenticator. The signing protocol may generate a signature that may be used in authentication with a cloud computing service. In some cases, the credential portions may be shared with other devices of the user. As such, the cloud authenticate may assist multiple user devices to authenticate with the cloud computing service.

Abstract: An orthodontic wax dispenser is described herein. For example, certain embodiments of the present disclosure relate to a pocket-sized orthodontic wax dispenser that has an internal storage compartment for orthodontic wax, a press mechanism (e.g., a threaded piston) to compress the stored wax through an extrusion aperture, and optionally a lid or cover, which may double as a wax cutting mechanism.

Abstract: A system or method for drilling includes autonomously controlling a rotary or percussive drilling process as it transitions through multiple materials with very different dynamics. The method determines a drilling medium based on real-time measurements and comparison to prior drilling data, and identifies the material type, drilling region, and approximately optimal setpoint based on data from at least one operating condition. The controller uses these setpoints initially to execute an optimal search to maximize performance by minimizing mechanical specific energy. Near-bit depth-of-cut estimations are performed using a machine learning prediction deployed in an embedded processor to provide high-speed ROP estimates. The sensing capability is coupled with a near-bit clutching mechanism to support drilling dysfunction mitigation.

Abstract: The present invention relates to the use of cannabidivarin (CBDV) in the treatment of autism spectrum disorder (ASD) and ASD-associated disorders such as Fragile X syndrome (FXS); Rett syndrome (RS); or Angelman syndrome (AS). In a further embodiment the invention relates to the use of CBDV in the treatment of schizophrenia. CBDV has been shown to be particularly effective in improving cognitive dysfunction in rodent models of ASD, FXS, RS, AS and schizophrenia. The CBDV is preferably substantially pure. It may take the form of a highly purified extract of cannabis such that the CBDV is present at greater than 95% of the total extract (w/w) and the other components of the extract are characterised. Alternatively, the CBDV is synthetically produced.

Abstract: A downhole shunt tube isolation system includes an isolation sleeve housing defining an isolation sleeve chamber and an isolation sleeve moveable within the isolation sleeve chamber between an open position and a closed position. The isolation sleeve has a slurry pathway that fluidically couples a first slurry tube segment to a second slurry tube segment with the isolation sleeve in the open position and fluidically decouples the first slurry tube segment from the second slurry tube segment in the closed position. The downhole shunt tube isolation system further includes a fluid channel in communication with the isolation sleeve chamber. The channel is initially closed to hydraulically lock the isolation sleeve in the open position. Additionally, the downhole shunt tube isolation system includes an actuation mechanism configured to open the fluid channel to hydraulically unlock the isolation sleeve and a biasing member to bias the isolation sleeve to the closed position.

Abstract: The present invention relates to the use of cannabidiol (CBD) in the treatment of Angelman syndrome (AS). CBD has been shown to be particularly effective in improving anxiety in rodent models of AS. The CBD is preferably substantially pure. It may take the form of a highly purified extract of Cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. Alternatively, the CBD is synthetically produced. Alternatively, the CBD may be used as a botanical drug substance (BDS) from a Cannabis plant in which CBD is the predominant cannabinoid. The CBD may also be present in combination with other cannabinoids and non-cannabinoid components such as terpenes. In use the CBD may be used concomitantly with one or more other medicaments. Alternatively, the CBD may be formulated for administration separately, sequentially or simultaneously with one or more medicaments or the combination may be provided in a single dosage form.

Abstract: Aspects hereof relate to a control system for a terrain working vehicle having an operator protection apparatus. In some aspects, the control system instructs and ceases an actuation of the operator protection apparatus to and between a raised position and a lowered position.

Abstract: Various embodiments describe methods, systems, and devices for distributing trigger-based function execution in a mesh network. Various embodiments receive a trigger designation that identifies a plurality of preestablished triggers used to initiate an action controlling an operation associated with a client device connected to the mesh network. A trigger subscription may be transmitted that causes hardware associated with each of the plurality of nodes to be configured to detect and report when any one of the plurality of preestablished triggers is detected by any one of the plurality of nodes, wherein the trigger subscription includes an update to a trigger list that identifies a designated node among the plurality of nodes that is configured to execute application logic for initiating at least one action controlling the operation associated with the client device connected to the mesh network, wherein the client device is remote from the designated node.

Abstract: Various methods, apparatuses/systems, and media for implementing a multi-tier intercommunication module (MTIM) for an automatic teller machine (ATM) to prevent fraudulent and forced transactions are provided. A processor within the MTIM verifies whether an anomaly withdrawal transaction is occurring based on analysis of a user's normal banking behavior. When anomaly transactions are detected, the processor transmits a notification to the user's registered Multi-Factor Authentication (MFA) device to verify whether the transaction is fraudulent. Additionally, the MTIM provides a continuous feedback loop of user location data when forced transactions have been triggered. Forced card transactions are allowed completion and the MTIM sends a custom security code (CSC) to the user's registered MFA mobile device.