Abstract: A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.

Abstract: A non-invasive optical measurement system comprises an optical source for generating source light, and an interferometer for splitting the source light into sample light and reference light, delivering the sample light into an anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combining the signal light and the reference light into at least three phase-modulated interference light patterns. The optical path lengths of the respective source light and sample light match within a coherence length of the source light.

Abstract: At least one magnetic field actuator is configured for generating an actuated magnetic field that at least partially cancels an outside magnetic field, thereby yielding a total residual magnetic field. A plurality of magnetometers are configured for taking measurements of the total residual magnetic field. The magnetometers include a plurality of coarse magnetometers and a plurality of fine magnetometers. A processor is configured for acquiring the total residual magnetic field measurements from the coarse magnetometers, estimating the total residual magnetic field at the fine magnetometers based on total residual magnetic field measurements acquired from the plurality of coarse magnetometers, and controlling the actuated magnetic field at least partially based on the total residual magnetic field estimates at the fine magnetometers in a manner that suppresses the total residual magnetic field at the fine magnetometers to a baseline level, such that at least one of the fine magnetometers is in-range.

Abstract: A calibration system for a magnetometer having an unknown gain is disclosed. A calibration magnetic field is generated at a calibration frequency of a known amplitude at the magnetometer. A measurement of the calibrating magnetic field is reported by the magnetometer. A ratio of an amplitude of the calibration magnetic field measurement reported by the magnetometer and the known amplitude of the calibrating magnetic field at the magnetometer is computed. The unknown gain of the magnetometer is determined at least partially based on computed ratio.

Abstract: One embodiment is a magnetic field measurement system that includes at least one magnetometer having a vapor cell, a light source to direct light through the vapor cell, and a detector to receive light directed through the vapor cell; at least one magnetic field generator disposed adjacent the vapor cell; and a feedback circuit coupled to the at least one magnetic field generator and the detector of the at least one magnetometer. The feedback circuit includes at least one feedback loop that includes a first low pass filter with a first cutoff frequency. The feedback circuit is configured to compensate for magnetic field variations having a frequency lower than the first cutoff frequency. The first low pass filter rejects magnetic field variations having a frequency higher than the first cutoff frequency and provides the rejected magnetic field variations for measurement as an output of the feedback circuit.

Abstract: An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.

Abstract: A magnetic resonance imaging method comprises performing imaging where more than one polarizing magnetic field strength is used during scanning and processing at least one image resulting from the scanning to yield an enhanced contrast image.

Abstract: One embodiment is a magnetic field measurement system that includes at least one magnetometer having a vapor cell, a light source to direct light through the vapor cell, and a detector to receive light directed through the vapor cell; at least one magnetic field generator disposed adjacent the vapor cell; and a feedback circuit coupled to the at least one magnetic field generator and the detector of the at least one magnetometer. The feedback circuit includes at least one feedback loop that includes a first low pass filter with a first cutoff frequency. The feedback circuit is configured to compensate for magnetic field variations having a frequency lower than the first cutoff frequency. The first low pass filter rejects magnetic field variations having a frequency higher than the first cutoff frequency and provides the rejected magnetic field variations for measurement as an output of the feedback circuit.

Abstract: A magnetic field measurement system includes at least one magnetometer; and at least one flux concentrator made of a high magnetic permeability material and configured to receive magnetic field signals from a source, to concentrate the magnetic field signals or reorient the magnetic field signals in a preselected direction, and to direct the concentrated or reoriented magnetic field signals toward at least one of the at least one magnetometer. In addition to, or as an alternative to, the flux concentrator, the system can include a passive shield made of the high magnetic permeability material. The system may also include active shielding.

Abstract: A magnetic field measurement system includes an array of magnetometers; at least one magnetic field generator configured to generate a compensation field across the array of magnetometers; and a controller coupled to the magnetometers and the at least one magnetic field generator and configured for adjusting a dynamic range and sensitivity of the array by adjusting a spatial variation of the compensation field to alter which of the magnetometers of the array operate in a measurement mode. Another magnetic field measurement system utilizes at least one magnetometer instead of the array. The controller is configured for adjusting a dynamic range and sensitivity of the array by adjusting a spatial variation of the compensation field to alter which of multiple domains within the at least one magnetometer operate in the measurement mode.

Abstract: A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.

Abstract: A magnetic field measurement system includes a body; sensors units that each include at least one magnetic field sensor disposed on or in the body; magnetic field generators, each of the magnetic field generators associated with a different one of the sensor units to provide active shielding when the magnetic field generator is activated; and a processor coupled to the magnetic field sensors and the magnetic field generators and configured to perform actions including: 1) selecting at least one of the sensor units, wherein, when multiple sensor units are selected, the selected sensor units are spatially separated from each other; 2) for each of the at least one selected sensor unit, activating the magnetic field generator associated with that selected sensor unit to provide active shielding; 3) receiving signals from the at least one selected sensor unit; and 4) repeating 1) through 3) at least once.

Abstract: Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.

Abstract: A magnetic field measurement system that includes at least one magnetometer; at least one magnetic field generator; a processor coupled to the at least one magnetometer and the at least one magnetic field generator and configured to: measure an ambient background magnetic field using at least one of the at least one magnetometer in a first mode selected from a scalar mode or a vector mode; generate, in response to the measurement of the ambient background magnetic field, a compensation field using the at least one magnetic field generator; and measure a target magnetic field using at least one of the at least one magnetometer in a spin exchange relaxation free (SERF) mode which is different from the first mode.

Abstract: An exemplary magnetic field measurement system includes a wearable sensor unit and a controller. The wearable sensor unit includes 1) a magnetometer comprising a photodetector and 2) a magnetic field generator configured to generate a compensation magnetic field configured to actively shield the magnetometer from ambient background magnetic fields. The controller is configured to interface with the magnetometer and the magnetic field generator and includes a differential signal measurement circuit configured to measure current output by the photodetector.

Abstract: An exemplary wearable sensor unit includes 1) a magnetometer comprising a vapor cell comprising an input window and containing an alkali metal, and a light source configured to output light that passes through the input window and into the vapor cell along a transit path, and 2) a temperature control circuit external to the vapor cell and configured to create a temperature gradient within the vapor cell, the temperature gradient configured to concentrate the alkali metal within the vapor cell away from the transit path of the light.

Abstract: A magnetic field measurement system includes a wearable device having a plurality of wearable sensor units. Each wearable sensor unit includes a plurality of magnetometers and a magnetic field generator configured to generate a compensation magnetic field configured to actively shield the plurality magnetometers from ambient background magnetic fields. A strength of a fringe magnetic field generated by the magnetic field generator of each of the wearable sensor units is less than a predetermined value at the plurality of magnetometers of each wearable sensor unit included in the plurality of wearable sensor units.

Abstract: A magnetic field generator includes a first planar substrate, a second planar substrate positioned opposite to the first planar substrate and separated from the first planar substrate by a gap, a first wiring set on the first planar substrate, a second wiring set on the second planar substrate, and one or more interconnects between the first planar substrate and the second planar substrate. The one or more interconnects electrically connect the first wiring set with the second wiring set to form a continuous electrical path. The continuous electrical path forms a conductive winding configured to generate, when supplied with a drive current, a first component of a compensation magnetic field configured to actively shield a magnetic field sensing region located in the gap from ambient background magnetic fields along a first axis that is substantially parallel to the first planar substrate and the second planar substrate.

Abstract: An exemplary magnetic field measurement system includes a wearable sensor unit and a single controller. The wearable sensor unit includes a plurality of magnetometers and a magnetic field generator configured to generate a compensation magnetic field configured to actively shield the magnetometers from ambient background magnetic fields. The single controller is configured to interface with the magnetometers and the magnetic field generator.

Abstract: An exemplary magnetic field measurement system includes a wearable sensor unit that includes a magnetometer, a magnetic field generator configured to generate a compensation magnetic field configured to actively shield the magnetometer from ambient background magnetic fields, a twisted pair cable interface assembly electrically connected to the magnetometer, and a coaxial cable interface assembly electrically connected to the magnetic field generator.