Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: A method monitors the state of a device having a first drive cylinder for receiving hydraulic fluid and a first drive piston which is movably arranged in the first drive cylinder. The method determines a speed of the first drive piston, establishes a difference between the determined speed of the first drive piston and an expected speed of the first drive piston, and determines a faulty state as a function of the difference established between the determined speed of the first drive piston and the expected speed of the first drive piston.

Abstract: The invention relates to a method for recovering beer from cold-hopped beer (20). According to the invention, the cold-hopped beer (20) is supplied to a decanting centrifuge (50) and is clarified by the decanting centrifuge (50) such that a separated solid substance (70) preferably preponderantly has hop sediments, and a liquid phase (80) is clarified beer.

Abstract: An apparatus for conveying thick matter has a drive cylinder for receiving hydraulic fluid, a drive piston, which is arranged in the drive cylinder, a conveying cylinder for receiving thick matter, a conveying piston, which is arranged in the conveying cylinder, and a piston rod, which is fastened to the drive piston for coupling motion together with the conveying piston. The drive cylinder has a rod-side opening for applying pressure to a rod side of the drive piston by way of hydraulic fluid and a crown-side opening for applying pressure to a crown side of the drive piston facing away from the rod side by the hydraulic fluid. A drive pump is designed to generate a drive volume flow having a drive pressure of hydraulic fluid for moving the drive piston. A pump connection is designed for variable connection of the drive pump to the rod-side opening or the crown-side opening for the flow of hydraulic fluid.

Abstract: A proximity sensor including a structure suspending at least one lens above a circuit board, light emitters operable to project light beams through the lens along a common projection plane, light detectors operable to detect amounts of light arriving through the lens at the detector, wherein an object in the projection plane reflects light from an emitter to one or more of the detectors, and wherein each emitter-detector pair, including one of the emitters and one of the detectors, when synchronously activated, is expected to generate a greater detection signal at the activated detector than the other detectors, were they to be synchronously activated with any of the emitters, when the object is located at a specific 2D location in the projection plane corresponding to the emitter-detector pair, and a processor identifying gestures performed by the object based on amounts of light detected by the detector of each emitter-detector pair.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: A thermoplastic composition includes: (a) from about 5 wt % to about 75 wt % of a polycarbonate component; (b) from about 10 wt % to about 60 wt % of a low refractive index polyester that is miscible with polycarbonate; (c) from about 10 wt % to about 30% of an inherently dissipative polymer (IDP) having a refractive index at room temperature of at least 1.50; and (d) from about 5 wt % to about 75 wt % of a copolymer comprising polycarbonate and isophthalate terephthalate resorcinol (ITR).

Abstract: A layer, in particular for forming an electrically conductive plate for an electrochemical cell, wherein the layer contains a first chemical element from the group of precious metals in the form of ruthenium in a concentration in the range of 50 to 99 at. % and at least a second chemical element in the form of silicon in a concentration of <10 at. %. Furthermore, a layer system, an electrically conductive plate and an electrochemical cell are provided.

Abstract: The present invention relates to an exhaust gas treatment system for treating an exhaust gas stream exiting a diesel engine, wherein said exhaust gas treatment system comprises a first catalyst having an inlet end and an outlet end and comprising a coating disposed on a substrate, wherein the coating comprises palladium supported on an oxidic material comprising zirconium and further comprises one or more of a vanadium oxide and a zeolitic material comprising one or more of copper and iron; a second catalyst having an inlet end and an outlet end and comprising a coating disposed on a substrate, wherein the coating comprises one or more of a vanadium oxide and a zeolitic material comprising one or more of copper and iron, wherein at most 0.0001 weight-% of the coating of the second catalyst consists of platinum group metal.

Abstract: A component for an electrochemical cell, wherein the component is present in the form of an electrode for a redox-flow cell or in the form of a bipolar plate for a fuel cell or an electrolyzer or in the form of a fluid diffusion layer for an electrolyzer, including a substrate which is formed from a material in the form of a metal sheet and/or an expanded metal grille, wherein the material is formed from a tin-nickel alloy or a tin-silver alloy or a tin-zinc alloy or a tin-bismuth alloy or a tin-antimony alloy. A redox-flow cell, a fuel cell and an electrolyzer are also provided.

Abstract: The present invention relates to a catalyst for the oxidation of hydrocarbon and the selective catalytic reduction of nitrogen oxides, the catalyst comprising a substrate comprising an inlet end, an outlet end, a substrate axial length extending from the inlet end to the outlet end and a plurality of passages defined by internal walls of the substrate extending therethrough; and a coating disposed on the surface of the internal walls of the substrate, wherein the surface de-fines the interface between the passages and the internal walls, wherein the coating comprises a platinum group metal component supported on a first oxidic material and further comprises a mixed oxide of vanadium and one or more of iron, erbium, bismuth, cerium, europium, gadolinium, holmium, lanthanum, lutetium, neodymium, praseodymium, promethium, samarium, scandium, terbium, thulium, ytterbium, yttrium, molybdenum, tungsten, manganese, cobalt, nickel, copper, aluminum and antimony, wherein the mixed oxide is supported on a second oxidic

Abstract: A method for indicating how a cancer patient will respond to a predetermined therapy relies on spatial statistical analysis of classes of cell centers in a digital image of tissue of the cancer patient. The cell centers are detected in the image of stained tissue of the cancer patient. For each cell center, an image patch that includes the cell center is extracted from the image. A feature vector is generated based on each image patch using a convolutional neural network. A class is assigned to each cell center based on the feature vector associated with each cell center. A score is computed for the image of tissue by performing spatial statistical analysis based on classes of the cell centers. The score indicates how the cancer patient will respond to the predetermined therapy. The predetermined therapy is recommended to the patient if the score is larger than a predetermined threshold.

Abstract: A method operates a construction material and/or viscous-material pump having: at least one conveying cylinder, the conveying cylinder being designed to receive and discharge construction material and/or viscous material; and at least one conveying piston, the conveying piston being disposed in the conveying cylinder for movement in order to draw construction material and/or viscous material into the conveying cylinder and to displace drawn-in construction material and/or viscous material out of the conveying cylinder.

Abstract: A vehicle having a thick matter pump has multiple supporting devices, a rotatable mast assembly with part-mast members, and a hydraulic drive assembly with hydraulic drives for the supporting devices and the mast assembly. A valve assembly is provided for the hydraulic drive assembly. The valve assembly has a group of proportional valves and a group of switching valve devices which are each connected to at least one hydraulic drive of the supporting devices or the part-mast members. The switching valve devices are connected downstream of the proportional valves. Exactly one switching valve device is supplied by exactly one proportional valve and is connected downstream of exactly one proportional valve such that outputs of the proportional valves lead exclusively to inputs of the switching valve devices.

Abstract: An aerial vehicle comprising: at least three support arms for interconnecting at least three motors; at least one battery module; at least one of the support arms is configured to support the at least one battery module such that the battery module forms a structural element of the support arm.

Abstract: Provided herein is a method of identifying a compound that induces the formation of Hepatitis B Virus (HBV) aberrant viral capsid structures.

Abstract: A layer system for coating a metal substrate in order to form a flow field plate includes at least one cover layer made of metal oxide; at least one intermediate layer, which supports the cover layer; and a lower layer, which supports the intermediate layer(s). The cover layer is formed of indium tin oxide; wherein the indium tin oxide is optionally doped with at least one element from the group comprising carbon, nitrogen, boron, fluorine, hydrogen, silicon, titanium, tin and zirconium. At least one intermediate layer is formed of titanium nitride and/or titanium carbide and/or titanium carbonitride and/or titanium niobium nitride and/or titanium niobium carbide and/or titanium niobium carbonitride and/or chromium nitride and/or chromium carbide and/or chromium carbonitride. The lower layer is formed of titanium or a titanium-niobium alloy or chromium.

Abstract: The present invention relates to a catalyst for the oxidation of NO, for the oxidation of ammonia and for the selective catalytic reduction of NOx, comprising a substrate, a first coating comprising one or more of a vanadium oxide and a zeolitic material comprising one or more of copper and iron; and a second coating comprising a platinum group metal component supported on a non-zeolitic oxidic material, wherein the second coating further comprises a zeolitic material comprising one or more of copper and iron.

Abstract: The present invention relates to a catalyst for the selective catalytic reduction of nitrogen oxide, the catalyst comprising a first coating comprising a 12-membered ring pore zeolitic material comprising a first metal which is one or more of copper and iron, and a second coating comprising an 8-membered ring pore zeolitic material comprising a second metal which is one or more of copper and iron.

Abstract: A method for optimizing the operation of a spinning machine with regard to quality and productivity is provided. An apparatus, comprising a control device and the spinning machine is provided. A yarn having specified yarn properties is produced, a quality parameter of the yarn is sensed during the spinning operation, a parameter for setting the production speed is specified, the quality parameter and the parameter for setting the production speed are evaluated, and the production speed is set in dependence on a target variable, the target variable comprising the quality parameter.