Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse.

Abstract: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.

Abstract: In a first aspect, provided herein is a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of the complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby the fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. The method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting the curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.

Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse by intake of alcohol.

Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse.

Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse by intake of alcohol.

Abstract: The present invention provides immediate release pharmaceutical compositions for oral administration that are resistant to abuse.

Abstract: The present invention relates to pharmaceutical compositions, which provide controlled release of a drug. The compositions are suitable for continuous administration as they remain effective throughout the treatment regimen. The present invention also relates to the use of the compositions for preparation of a medicament for continuous treatment of an individual.

Abstract: The present disclosure relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present disclosure also relates to the use of pharmaceutical compositions in the treatment of pain.

Abstract: Controlled release formulations and methods for preparing controlled release formulations for delivery of active drug substances are described herein. The formulations described herein may be employed to produce pharmaceutical compositions, such as controlled release dosage forms, adjusted to a specific administration scheme.

Abstract: The present invention relates to immediate release pharmaceutical compositions for oral administration that are resistant to abuse by intake of alcohol. In particular, this disclosure provides immediate release pharmaceutical compositions comprising a polyglycol having a molecular weight of from about 900 to about 17,000 daltons, a drug substance, one or more effervescent agents, and, optionally, one or more disintegrants, such that the composition is formulated to be resistant to abuse by intake of alcohol.

Abstract: A hydraulic system, preferably for actuating and engaging a mobile slurry pump, includes a primary circuit, actuating a first hydraulic consumer, which circuit has a hydraulic drive assembly including at least one motor-driven hydraulic pump. The hydraulic system further includes a secondary circuit, actuating a second hydraulic consumer, which circuit has a second hydraulic drive assembly including at least one additional motor-driven hydraulic pump. In a first operating state, hydraulic oil from a common tank can be admitted to the hydraulic consumers arranged in the primary circuit and in the secondary circuit via the hydraulic drive assemblies thereof, independently of one another. In a second operating state, a portion of the hydraulic oil is supplied from the primary circuit to the secondary circuit to actuate the second consumer.

Abstract: A system for measuring the position of a rod element as, for example, a hydraulically or pneumatically operated piston rod. Unlike the prior art, the system according to the present invention employs a measuring principle that does not require preparatory treatment of the rod element as is required in the known solutions. The system employs direct time of flight measurements with the aid of acoustic surface waves that are introduced into the rod element. The instrument is retrofittable on existing cylinders without any modification/ reconstruction thereof An EMAT principle is employed to introduce the surface waves into the measurement in a non-contact manner.

Abstract: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.

Abstract: Driving arrangement (11) for a pump, compressor or similar, adapted to provide alternating pressure in at least two chambers (27a, 27b, 27?, 27?), such as chambers of a pump or compressor, as result of a reciprocating movement of a bar element (23). The bar element is connected to two movable pressure chamber faces being pistons (21a, 21 b) or plungers having fluid connection to said chambers, which bar element (23) is reciprocally supported in a housing (19). The driving arrangement further comprises an electric motor (31) which is adapted to provide the reciprocating movement of the bar element (23). The bar element extends through the rotor (31b) of the electric motor (31). The electric motor is an electric rotary motor. The invention also relates to a pump assembly with a plurality of such driving arrangements.

Abstract: The invention relates to a hydraulic system, preferably for piloting and actuating a two-cylinder thick matter pump. The hydraulic system comprises a tank (68) for receiving hydraulic oil, a primary circuit having at least one hydraulic consumer (AH, MH) which has at least one primary pump (36, 38, 61, 70), which is loaded with hydraulic oil via a first suction line (42), and is connected on the outlet side to at least one first return line, and which has a suction/return filter (40) which communicates with the first suction line (42) on the outlet side and is loaded on the inlet side with return oil from the at least one return line. A special feature of the invention consists in that the first suction line (42) communicates with the tank (68) via a separate replenishing suction line (86) and a suction filter (66), wherein a replenishing suction valve (88) which is preloaded in the direction of the suction filter (66) is arranged in the replenishing suction line (86).

Abstract: The present disclosure relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present disclosure also relates to the use of pharmaceutical compositions in the treatment of pain.

Abstract: In a first aspect, the present invention relates to a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of said complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby said fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. Said method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting said curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.

Abstract: A method of determining a degree of yaw error of a wind turbine is provided. The method includes obtaining wind pressure measurement values from in front of the rotor plane, which wind pressure measurement values exhibit a periodic nature related to a rotation of a spinner of the wind turbine, performing a signal processing step to process the wind pressure measurement values to determine a phase offset of the wind pressure measurement values relative to an angular reference, and deriving a yaw error angle from the phase offset. A method of establishing a relationship between a phase offset of wind pressure measurement values and a degree of yaw error of a wind turbine, a yaw error determination unit, and a wind turbine are also provided.

Abstract: A process for preparing nitric acid by: catalytically oxidizing ammonia, to obtain a gas mixture containing NO and O2; cooling and condensing the gas mixture, thereby further oxidizing NO with O2, to obtain a gas stream containing NO2/N2O4 and an aqueous solution containing nitric acid; and countercurrently absorbing the NO2/N2O4 from the gas stream in an absorber with process water (H2O), to obtain nitric acid and an NOx-containing absorber offgas, wherein the water content of the nitric acid is regulated to a concentration in the range from 50 to 77.8% by weight and the NOx content of the absorber offgas to a concentration in the range from 20 to 500 ppm, by continuously measuring the water content of the process air supplied to the catalytic gas phase oxidation and, as a function of this, adjusting the amount of process water (Q-H2O) fed to the absorber.