Abstract: Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.

Abstract: A configurable device for the flexible provision of connections and/or functions in a biopharmaceutical process includes a body in which predefined pipe sections and plug-in locations are formed by recesses in the material of the body. The configurable device further includes a plurality of functional elements which are adapted to be inserted into the plug-in locations.

Abstract: A device (1) for accommodating a disposable container (44) has a receptacle (10) with at least one receptacle wall (16) that defines an interior of the receptacle (10) for accommodating the disposable container (44). The device includes a temperature control unit for controlling the temperature of the receptacle wall (16). A lighting device (50) is located on an inner face of the receptacle wall (16) that faces the interior of the receptacle (10) and that has the temperature controlled by the temperature control unit. The lighting device (50) is designed to emit light into the interior of the receptacle (10).

Abstract: A method for operating a condition monitoring system of a vibrating machine in the form of a vibrating conveyor or a vibrating screen, it is provided that the condition monitoring system has at least one sensor designed for motion detection and/or acceleration detection, which is mounted on the vibrating machine. The sensor generates measurement data, which is further processed into characteristic values in a processing unit associated with the sensor. The characteristic values are stored as a data set or a plurality of data sets. The data sets and/or the data sets expanded to include metadata are transferred to a data storage and stored there. A knowledge base for an expert system is generated taking into account the information provided by the data sets and/or built on theoretical models.

Abstract: A filtration system (1) has a filtration unit (2) with at least one filter element (4) for filtration of a fluid. The at least one filter element (4) has a main flow direction (C) for the fluid. The filtration unit (2) is configured to tilt the at least one filter element (4) around a tilting axis (B) to change an orientation of the main flow direction (C). A main unit (3) is fluidly connectable to the filtration unit (2) and includes a supply unit (18) configured to supply the fluid to the at least one filter element (4). A control unit is configured to control supplying and/or evacuating the fluid to/from the at least one filter element (4) and to control tilting of the at least one filter element (4) around the tilting axis (B).

Abstract: A configurable device (10) for the flexible provision of connections and/or functions in a biopharmaceutical process comprises a body (20) in which predefined pipe sections (22) and plug-in locations (24) are formed by recesses in the material of the body (20). The configurable device (10) further comprises a plurality of functional elements (26) which are adapted to be inserted into the plug-in locations (24).

Abstract: A presterilizable filtration system is provided and is to be disposed of after a single use. The system has a recirculation tank and a filtration module that are connected to each other in a circuit via a hose system that can be regulated by at least one valve. The valve has a disposable separate valve part that can be integrated in the hose system and a reusable actuator.

Abstract: A mobile device for detecting the state parameters and operating parameters of vibrating machines, which comprise sensor units and an evaluation unit connected to the sensor units, the measurement data detected by the sensor units being wirelessly transmittable to the evaluation unit, and each sensor unit being equipped with at least three acceleration sensors oriented orthogonally to each other and an integrated circuit for processing the measurement data detected by the sensor units, it is provided that at least four sensor units form a sensor network, the sensor units being detachably fastenable at a distance from each other with an undetermined orientation/direction to the vibrating machine, and a local coordinate system being defined by the at least three acceleration sensor of a sensor unit.

Abstract: The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).

Abstract: A clamping device (1) is provided for cartridge filtration modules (2) that have a distribution plate (3) with a feed channel (18), a retentate channel (21), a filtrate channel, and a first contact surface (8). At least one filter cartridge can be clamped between a contact surface (8) of the distribution plate (3) and a clamping surface (29) of a clamping plate (4) that can be moved orthogonally to the contact surface (8). The cartridge filtration modules (2) can be stacked on one another in an area of their distribution plates (3). A common distribution plate (3) for adjacent filter cartridge arrangements can clamped against the contact surface (8). Adjacent filter cartridge arrangements can be connected in a parallel circuit via the distribution plate (3), and the cartridge filtration modules (2) that can be stacked on top of one another can be connected in series via the distribution plates (3).

Abstract: A method for operating a condition monitoring system of a vibrating machine in the form of a vibrating conveyor or a vibrating screen, it is provided that the condition monitoring system has at least one sensor designed for motion detection and/or acceleration detection, which is mounted on the vibrating machine. The sensor generates measurement data, which is further processed into characteristic values in a processing unit associated with the sensor. The characteristic values are stored as a data set or a plurality of data sets. The data sets and/or the data sets expanded to include metadata are transferred to a data storage and stored there. A knowledge base for an expert system is generated taking into account the information provided by the data sets and/or built on theoretical models.

Abstract: A filtration system (1) has a filtration unit (2) with at least one filter element (4) for filtration of a fluid. The at least one filter element (4) has a main flow direction (C) for the fluid. The filtration unit (2) is configured to tilt the at least one filter element (4) around a tilting axis (B) to change an orientation of the main flow direction (C). A main unit (3) is fluidly connectable to the filtration unit (2) and includes a supply unit (18) configured to supply the fluid to the at least one filter element (4). A control unit is configured to control supplying and/or evacuating the fluid to/from the at least one filter element (4) and to control tilting of the at least one filter element (4) around the tilting axis (B).

Abstract: A clamping device (1) is provided for cartridge filtration modules (2) that have a distribution plate (3) with a feed channel (18), a retentate channel (21), a filtrate channel, and a first contact surface (8). At least one filter cartridge can be clamped between a contact surface (8) of the distribution plate (3) and a clamping surface (29) of a clamping plate (4) that can be moved orthogonally to the contact surface (8). The cartridge filtration modules (2) can be stacked on one another in an area of their distribution plates (3). A common distribution plate (3) for adjacent filter cartridge arrangements can clamped against the contact surface (8). Adjacent filter cartridge arrangements can be connected in a parallel circuit via the distribution plate (3), and the cartridge filtration modules (2) that can be stacked on top of one another can be connected in series via the distribution plates (3).

Abstract: A device (1) for accommodating a disposable container (44) has a receptacle (10) with at least one receptacle wall (16) that defines an interior of the receptacle (10) for accommodating the disposable container (44). The device includes a temperature control unit for controlling the temperature of the receptacle wall (16). A lighting device (50) is located on an inner face of the receptacle wall (16) that faces the interior of the receptacle (10) and that has the temperature controlled by the temperature control unit. The lighting device (50) is designed to emit light into the interior of the receptacle (10).

Abstract: The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).

Abstract: A filter holder for receiving filter cassettes (19) and a method for sterilizing the filter are provided. The filter holder has first and second parallel plates (3, 4). The first plate (3) is fixed and the second plate (4) is movable along at least one rail (2) by a drive (7, 9) so that the filter cassettes (19) can be clamped between the plates (3, 4) with a predefined clamping pressure. The drive (7, 9) is designed to be removable. The at least one rail (2) has at least one tension rod (5) with a spring clamping element (6) so that the first and second plates (3, 4) can be clamped with a pre-definable pressure against the filter cassettes (19).

Abstract: A vibrating machine is provided that includes a condition-monitoring device that has a first vibrating body supported flexibly in relation to a second vibrating body or a base, a first exciter that produces a targeted vibration behavior of the vibrating machine or the vibrating body. The condition-monitoring device has at least one first micro-electro-mechanical device in the form of an inertial sensor with at least three acceleration sensors and at least three yaw-rate sensors.

Abstract: A filter holder for receiving filter cassettes (19) and a method for sterilizing the filter are provided. The filter holder has first and second parallel plates (3, 4). The first plate (3) is fixed and the second plate (4) is movable along at least one rail (2) by a drive (7, 9) so that the filter cassettes (19) can be clamped between the plates (3, 4) with a predefined clamping pressure. The drive (7, 9) is designed to be removable. The at least one rail (2) has at least one tension rod (5) with a spring clamping element (6) so that the first and second plates (3, 4) can be clamped with a pre-definable pressure against the filter cassettes (19).

Abstract: The invention relates to a special plasma source designated as a plasma intractor (PI) for producing a cold, homogeneous plasma under atmospheric pressure conditions, which plasma source can be used advantageously to excite and control reactive processes in flowing media. The device according to the invention is characterized in that the device comprises at least 6 elongated electrodes (2) and a molded body (1) made of insulating material, the molded body (1) being provided with an elongated cylindrical cavity (7) and with additional holes, which are guided parallel to the cavity (7) and arranged symmetrical to the axis of the cavity and equidistant to one another, and the electrodes (2) are embedded in holes of the molded body (1) and are connected to an AC high-voltage supply in such a way that the polarities of respective adjacent electrodes are opposite in each phase of the voltage period.

Abstract: Diaphragm valve having a valve body with an inlet and an outlet, a sealing membrane, and a connecting piece connecting the sealing membrane to a pressure piece of a drive. The valve body, the sealing membrane and the connecting piece are rigidly connected together to form an interchangeable, sealed valve body unit that can be connected to the drive. The connecting piece is molded on the sealing membrane, and the valve body and the sealing membrane are welded ultrasonically to one another.