Patents by Inventor Jan Simons

Jan Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11550008
    Abstract: The invention relates to the generation of RF pulses for MRI applications.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: January 10, 2023
    Assignee: Koninklijke Philips N.V.
    Inventor: Jan Simons
  • Publication number: 20210382125
    Abstract: The invention relates to the generation of RF pulses for MRI applications.
    Type: Application
    Filed: October 21, 2019
    Publication date: December 9, 2021
    Inventor: JAN SIMONS
  • Patent number: 9756423
    Abstract: A method of removing an electric crosstalk contribution is disclosed. This crosstalk exists in a monitoring signal from a monitored electro-mechanical transducer in a device comprising a plurality of electro-mechanical transducers which are driven by actuation signals so as to produce acoustic waves in an acoustic frequency range. The method comprises the steps of: (a) applying an actuation signal to at least one of the transducers other than the monitored transducer; (b) detecting the monitoring signal in a high frequency range outside of the acoustic frequency range; (c) deriving, from the detected monitoring signal, a number of parameters that characterize the electric crosstalk; and (d) using said parameters to calculate the electric crosstalk contribution in the acoustic frequency range.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: September 5, 2017
    Assignee: OCÉ-TECHNOLOGIES B.V.
    Inventor: Jan Simons
  • Publication number: 20170078792
    Abstract: A method of removing an electric crosstalk contribution is disclosed. This crosstalk exists in a monitoring signal from a monitored electro-mechanical transducer in a device comprising a plurality of electro-mechanical transducers which are driven by actuation signals so as to produce acoustic waves in an acoustic frequency range. The method comprises the steps of: (a) applying an actuation signal to at least one of the transducers other than the monitored transducer; (b) detecting the monitoring signal in a high frequency range outside of the acoustic frequency range; (c) deriving, from the detected monitoring signal, a number of parameters that characterize the electric crosstalk; and (d) using said parameters to calculate the electric crosstalk contribution in the acoustic frequency range.
    Type: Application
    Filed: September 1, 2016
    Publication date: March 16, 2017
    Applicant: Océ-Technologies B.V.
    Inventor: Jan SIMONS
  • Publication number: 20070178452
    Abstract: Disclosed is a method in which DNA sequences derived from microsome-associated mRNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 2, 2007
    Inventors: Pascal Bouffard, John Herrmann, Chunli Huang, Michael Jeffers, Jingfang Ju, Luca Rastelli, Juliette Shimkets, Jan Simons, Bruce Taillon
  • Publication number: 20070117121
    Abstract: New biochemical protocols for high throughput processing of mRNA samples into cDNA libraries with adaptor sequences compatible with automated sequencing systems are provided. The provided methods produces cDNA libraries which do not have 3? bias associated with current cDNA library production methods. New methods for the production of DNA libraries from DNA are also provided.
    Type: Application
    Filed: September 18, 2006
    Publication date: May 24, 2007
    Inventors: Stephen Hutchison, Jan Simons, David Willoughby
  • Publication number: 20060292611
    Abstract: The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a large target nucleic acid into a single small DNA construct for rapid cloning, sequencing, or amplification.
    Type: Application
    Filed: June 6, 2006
    Publication date: December 28, 2006
    Inventors: Jan Berka, Zhoutao Chen, Michael Egholm, Brian Godwin, Stephen Hutchison, John Leamon, Gary Sarkis, Jan Simons
  • Publication number: 20060228721
    Abstract: The claimed invention provides for new sample preparation methods enabling direct sequencing of PCR products using pyrophosphate sequencing techniques. The PCR products may be specific regions of a genome. The techniques provided in this disclosure allows for SNP (single nucleotide polymorphism) detection, classification, and assessment of individual allelic polymorphisms in one individual or a population of individuals. The results may be used for diagnostic and treatment of patients as well as assessment of viral and bacterial population identification.
    Type: Application
    Filed: April 12, 2005
    Publication date: October 12, 2006
    Inventors: John Leamon, William Lee, Jan Simons, Brian Desany, Michael Ronan, James Drake, Kenton Lohman, Michael Egholm, Jonathan Rothberg
  • Patent number: 4011400
    Abstract: An apparatus is described for reading a radiation-reflecting record carrier on which information is stored in an optically readable track-shaped phase structure. The apparatus inter alia includes a radiation source, an objective system and a radiation-sensitive detection system. By a suitable arrangement and a suitable choice of the power of a cylindrical lens, which lens in conjunction with a four-quadrant detector supplies a focussing signal, it is possible to detect centering-errors with the aid of only two additional detectors in the plane of the four-quadrant detector.
    Type: Grant
    Filed: September 4, 1975
    Date of Patent: March 8, 1977
    Assignee: U.S. Philips Corporation
    Inventors: Carel Arthur Jan Simons, Hendrik' T. Lam
  • Patent number: 3978278
    Abstract: An apparatus is described for reading a record carrier on which information is stored in an optically readable structure. Between a radiation source and an objective system a mirror system is disposed, by means of which the entrance pupil of the objective lens can be imaged onto beam-controlling elements which deflect the read beam over the information structure.
    Type: Grant
    Filed: April 29, 1974
    Date of Patent: August 31, 1976
    Assignee: U.S. Philips Corporation
    Inventors: Gijsbertus Bouwhuis, Adrianus Jacobus Jozef Franken, Carel Arthur Jan Simons
  • Patent number: 3969573
    Abstract: An apparatus is described for reading a record carrier on which information is stored in an optically readable structure. Between a radiation source and an objective system, a polarization-sensitive beam splitter and a .lambda./4 plate are disposed. The optic axis of the .lambda./4 plate is perpendicular to the end faces, so that the plate may be thick and may be rotated in its own plane.
    Type: Grant
    Filed: April 29, 1974
    Date of Patent: July 13, 1976
    Assignee: U.S. Philips Corporation
    Inventors: Gijsbertus Bouwhuis, Carel Arthur Jan Simons