Abstract: Provided herein are crystalline Forms (or polymorphs) I, II, III, IV, V, VI, and VII of N-(5-((4-(1H-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide tosylate salt and methods of inhibiting the activity of EGFR or treating a disease mediated by EGFR by using an effective amount of at least one crystalline form described herein.

Abstract: An integrated circuit (IC) chip device includes testing interface circuity and testing circuitry to test the operation of the IC chips of the IC chip device. The IC chip device includes a first IC chip that comprises first testing circuitry. The first testing circuitry receives a mode select signal, a clock signal, and encoded signals, and comprises finite state machine (FSM) circuitry, decoder circuitry, and control circuitry. The FSM circuitry determines an instruction based on the mode select signal and the clock signal. The decoder circuitry decodes the encoded signals to generate a decoded signal. The control circuitry generates a control signal from the instruction and the decoded signal. The control signal indicates a test to be performed by the first testing circuitry.

Abstract: An integrated circuit (IC) chip device includes testing interface circuitry and testing circuitry to test the operation of the IC chips of the IC chip device. The IC chip device includes a first IC chip that comprises first testing circuitry. The first testing circuitry receives a mode select signal, a clock signal, and encoded signals, and comprises finite state machine (FSM) circuitry, decoder circuitry, and control circuitry. The FSM circuitry determines an instruction based on the mode select signal and the clock signal. The decoder circuitry decodes the encoded signals to generate a decoded signal. The control circuitry generates a control signal from the instruction and the decoded signal. The control signal indicates a test to be performed by the first testing circuitry.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: Provided is a degradable microparticle with a grain size in a range of 2 micrometers to 1400 micrometers, and the degradable microparticle comprises poly(glycerol sebacate), poly(glycerol maleate), poly(glycerol succinate-co-maleate), poly(glycerol succinate), poly(glycerol malonate), poly(glycerol glutarate), poly(glycerol adipate), poly(glycerol pimelate), poly(glycerol suberate), poly(glycerol azelate), or any combination thereof. A degradable product produced from the degradable microparticles can obtain the desired degradation effect and can be produced by chemical synthesis to reduce the production cost. With these advantages, the applicability of the degradable microparticles is improved.

Abstract: The present disclosure relates to a scaffold with staircase microstructure for cell or tissue culture, comprising multiple layers. Each layer defines a plurality of through holes, and the through holes of each layer is in communication with a corresponding through holes of an adjacent layer. A method for culturing cell and tissue regeneration is also provided.

Abstract: A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules functioning as precursor molecules to induce tribopolymerization and forming in situ protective tribofilm with desirable robustness and low shear resistance. Each lubricant additive molecule includes one or more surface-active groups attractable to target surface, and a carbon containing component operable connected to the one or more surface active groups. The carbon containing component comprise a carbon ring structure having a high ring strain that is metastable and activatable with a ring-opening reaction. A less stable carbon ring structure is more readily activated to the intermediate state, preferable to form more active fragments. Increasing the adsorption strength further is beneficial to prolonging the residence time of additive molecules on the target surface, thereby facilitating the dissociation of molecules and subsequent polymerization.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: A method for preparing a biodegradable polyester elastomer includes a following steps comprising: dissolving a predetermined amount of titanium dioxide in an aqueous mixture of sulphuric acid, DI water, and ethanol to form a first solution; refluxing the first solution in a silicone oil bath and a stirring speed of 300-450 rpm at a temperature of 90-100° C. to form a second solution; preparing a solid superacid catalyst by drying, grinding and calcining sulfated titania and using this catalyst to produce a biodegradable polyester elastomer.

Abstract: A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules functioning as precursor molecules to induce tribopolymerization and forming in situ protective tribofilm with desirable robustness and low shear resistance. Each lubricant additive molecule includes one or more surface-active groups attractable to target surface, and a carbon containing component operable connected to the one or more surface active groups. The carbon containing component comprise a carbon ring structure having a high ring strain that is metastable and activatable with a ring-opening reaction. A less stable carbon ring structure is more readily activated to the intermediate state, preferable to form more active fragments. Increasing the adsorption strength further is beneficial to prolonging the residence time of additive molecules on the target surface, thereby facilitating the dissociation of molecules and subsequent polymerization.

Abstract: Provided is a degradable microparticle with a grain size in a range of 2 micrometers to 1400 micrometers, and the degradable microparticle comprises poly(glycerol sebacate), poly(glycerol maleate), poly(glycerol succinate-co-maleate), poly(glycerol succinate), poly(glycerol malonate), poly(glycerol glutarate), poly(glycerol adipate), poly(glycerol pimelate), poly(glycerol suberate), poly(glycerol azelate), or any combination thereof. A degradable product produced from the degradable microparticles can obtain the desired degradation effect and can be produced by chemical synthesis to reduce the production cost. With these advantages, the applicability of the degradable microparticles is improved.

Abstract: A method for preparing a biodegradable polyester elastomer includes a step of carrying out an esterification reaction to produce a glycerol-sebacic acid prepolymer, a glycerol-maleic acid prepolymer, or a glycerol-adipic acid prepolymer. The esterification reaction is carried out between sebacic acid, maleic acid, or adipic acid and glycerol in a molar ratio of 1:1-2 with an effective amount of sulfated titania under a vacuum pressure of 300-600 mTorr. Therefore, the production time of the biodegradable polyester elastomer can be reduced significantly.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: An optical package structure includes a first conductive frame, a second conductive frame, a light receiver, and a light-permeable package compound. The first and second conductive frames are arranged apart from each other and have a light entrance there-between. The light receiver includes a light receiving region and two soldering portions arranged on a surface thereof. The two soldering portions are respectively arranged at two opposite sides of the light receiving region, and are respectively soldered onto the first and second conductive frames, such that the light receiving region faces the light entrance. At least part of the first conductive frame, at least part of the second conductive frame, and the light receiver are embedded in the light-permeable package compound. The light receiver is configured to receive a light signal traveling through the light-permeable package compound and the light entrance.

Abstract: An optical package structure includes a first conductive frame, a second conductive frame, a light receiver, and a light-permeable package compound. The first and second conductive frames are arranged apart from each other and have a light entrance there-between. The light receiver includes a light receiving region and two soldering portions arranged on a surface thereof. The two soldering portions are respectively arranged at two opposite sides of the light receiving region, and are respectively soldered onto the first and second conductive frames, such that the light receiving region faces the light entrance. At least part of the first conductive frame, at least part of the second conductive frame, and the light receiver are embedded in the light-permeable package compound. The light receiver is configured to receive a light signal traveling through the light-permeable package compound and the light entrance.

Abstract: A printable biodegradable polymer composite includes PGSA, a biodegradable photo-initiator and material selected from the group consisting PCL-DA and PEG-DA uniformly blended together. By adjusting the blending ratio, the elasticity, mechanical properties and degradation patterns may be adjusted for producing a tissue, organ or related bio-product by 3D-printing.

Abstract: A printable biodegradable polymer composite comprises PGSA, biodegradable photo-initiator and material selected from the group consisting PCL-DA and PEG-DA being uniformly blended together. By adjusting blending ratio of the present invention, the elasticity, mechanical properties and degradation patterns of the present invention may be adjusted for producing various tissue, organ or related bio-product by 3D-printing.

Abstract: A method for preparing a biodegradable polyester elastomer includes a step of carrying out an esterification reaction to produce a glycerol-sebacic acid prepolymer, a glycerol-maleic acid prepolymer, or a glycerol-adipic acid prepolymer. The esterification reaction is carried out between sebacic acid, maleic acid, or adipic acid and glycerol in a molar ratio of 1:1-2 with an effective amount of sulfated titania under a vacuum pressure of 300-600 mTorr. Therefore, the production time of the biodegradable polyester elastomer can be reduced significantly.

Abstract: A method of using lubricant compositions to reduce wear between two surfaces exposed to a load condition of at least 1 GPa is provided. The lubricant compositions comprise polysiloxane base oils having alkylaryl or a combination of alkyl and aryl functionality. The polysiloxane base oils may be defined according to the formula: wherein R, R?, and R? are independently selected, such that R is an alkyl group having between 1-3 carbon atoms; R? is an alkylaryl group comprising alkyl functionality with 3-12 carbon atoms and aryl functionality with 6 to 12 carbon atoms; R? is an alkyl group having between 1-3 carbon atoms or an alkylaryl group comprising alkyl functionality with 3-12 carbon atoms and aryl functionality with 6 to 12 carbon atoms; and m and n are integers, such that 8<(m+n)<500.