Patents by Inventor Janice G. Pero
Janice G. Pero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11072807Abstract: This invention relates to the biosynthesis of organic acids in genetically modified microorganisms. More specifically, this invention provides genetically modified microorganisms that are particularly tolerant to organic acids at low pH and are capable of producing organic acids by fermentation at low pH.Type: GrantFiled: September 13, 2013Date of Patent: July 27, 2021Assignee: PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITEDInventors: R. Rogers Yocum, Sudhanshu Dole, Janice G. Pero
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Publication number: 20190345437Abstract: This present invention is in the field of producing renewable chemical feedstocks using biocatalysts that have been genetically engineered to increase their ability to convert renewable carbon resources into useful compounds. More specifically, the present invention provides a process for producing muconic acid form renewable carbon resources using a genetically modified organism.Type: ApplicationFiled: July 10, 2019Publication date: November 14, 2019Applicant: PTTGC INNOVATION AMERICA CORPORATIONInventors: R. Rogers YOCUM, Wei GONG, Sudhanshu DOLE, Ryan SILLERS, Meghal GANDHI, Janice G. PERO
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Publication number: 20150240270Abstract: This invention relates to the biosynthesis of organic acids in genetically modified microorganisms. More specifically, this invention provides genetically modified microorganisms that are particularly tolerant to organic acids at low pH and are capable of producing organic acids by fermentation at low pH.Type: ApplicationFiled: September 13, 2013Publication date: August 27, 2015Applicant: MYRIANT CORPORATIONInventors: R. Rogers Yocum, Sudhanshu Dole, Janice G. Pero
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Patent number: 9017976Abstract: This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.Type: GrantFiled: November 17, 2010Date of Patent: April 28, 2015Assignee: Myriant CorporationInventors: Wei Gong, Sudhanshu Dole, Tammy Grabar, Andrew Christopher Collard, Janice G. Pero, R. Rogers Yocum
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Publication number: 20150044755Abstract: This present invention is in the field of producing renewable chemical feedstocks using biocatalysts that have been genetically engineered to increase their ability to convert renewable carbon resources into useful compounds. More specifically, the present invention provides a process for producing muconic acid form renewable carbon resources using a genetically modified organism.Type: ApplicationFiled: January 29, 2013Publication date: February 12, 2015Applicant: MYRIANT CORPORATIONInventors: R. Rogers Yocum, Wei Gong, Sudhanshu Dole, Ryan Sillers, Meghal Gandhi, Janice G. Pero
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Publication number: 20120220000Abstract: This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.Type: ApplicationFiled: November 17, 2010Publication date: August 30, 2012Inventors: Wei Gong, Sudhanshu Dole, Tammy Grabar, Andrew Chirstopher Collard, Janice G. Pero, R. Rogers Yocum
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Patent number: 8232081Abstract: The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ?-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX, as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured.Type: GrantFiled: November 8, 2004Date of Patent: July 31, 2012Assignee: BASF SEInventors: R. Rogers Yocum, Thomas A. Patterson, Theron Hermann, Janice G. Pero
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Patent number: 8148117Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.Type: GrantFiled: October 23, 2006Date of Patent: April 3, 2012Assignee: Evonik Degussa GmbHInventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Patent number: 7989187Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: GrantFiled: July 3, 2003Date of Patent: August 2, 2011Assignee: BASF SEInventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Publication number: 20100003727Abstract: The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased. The present invention also relates to the use of such microorganisms for producing methionine.Type: ApplicationFiled: February 14, 2008Publication date: January 7, 2010Inventors: Oskar Zelder, Hartwig Schröder, Corinna Klopprogge, Andrea Herold, Stefan Haefner, Thomas A. Patterson, R. Rogers Yocum, Janice G. Pero
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Publication number: 20090298136Abstract: This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.Type: ApplicationFiled: July 18, 2006Publication date: December 3, 2009Applicant: BASF AGInventors: Oskar Zelder, Stefan Haefner, Corinna Klopprogge, Hartwig Schroder, Andrea Herold, Thomas A. Patterson, Theron Hermann, R. Rogers Yocum, Mark K. William, Janice G. Pero
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Publication number: 20090298137Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.Type: ApplicationFiled: October 23, 2006Publication date: December 3, 2009Applicant: BASF AGInventors: Oskar Zelder, Andreas Herold, Corinna Klopprogge, Hartwig Schröder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Publication number: 20090191610Abstract: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.Type: ApplicationFiled: August 18, 2006Publication date: July 30, 2009Applicant: Evonik Degussa GmbHInventors: Oskar Zelder, Andrea Herold, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner, Elmar Heinzle, Christoph Wittmann, Jens Kroemer, Janice G. Pero, R. Rogers Yocum, Thomas A. Patterson, Mark Williams, Theron Herman
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Publication number: 20080166777Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: ApplicationFiled: July 16, 2007Publication date: July 10, 2008Applicant: BASF AktiengesellschaftInventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Patent number: 7291489Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: GrantFiled: July 3, 2003Date of Patent: November 6, 2007Assignee: BASF AktiengesellschaftInventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Patent number: 7244593Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: GrantFiled: January 18, 2002Date of Patent: July 17, 2007Assignee: BASF AktiengesellschaftInventors: R. Roger Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Patent number: 7220561Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: GrantFiled: January 19, 2002Date of Patent: May 22, 2007Assignee: BASF AktiengesellschaftInventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Roger Yocum, Kai-Uwe Baldenius, Christine Beck
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Patent number: 7091000Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.Type: GrantFiled: February 10, 2003Date of Patent: August 15, 2006Assignee: DSM Nutritional Products, Inc.Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
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Patent number: 6841366Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.Type: GrantFiled: September 28, 1999Date of Patent: January 11, 2005Assignee: DSM IP Assets B.V.Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
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Publication number: 20040146996Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: ApplicationFiled: July 3, 2003Publication date: July 29, 2004Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann