Patents by Inventor Janice G. Pero

Janice G. Pero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
    Publication number: 20040146997
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. The method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Application
    Filed: January 9, 2004
    Publication date: July 29, 2004
    Applicant: ROCHE VITAMINS, INC.
    Inventors: Scott W. Van Arsdell, R. Rogers Yocum, John B. Perkins, Janice G. Pero
  • Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
    Patent number: 6737256
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: May 18, 2004
    Assignee: Roche Vitamins Inc.
    Inventors: Scott W. Van Arsdell, R. Rogers Yocum, John B. Perkins, Janice G. Pero
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040091979
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Inventors: Rogers R. Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Publication number: 20040086982
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 6, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
    Publication number: 20040048343
    Abstract: The present invention features methods of producting 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (“HMBPA”) and &agr;-hydroxyisovalerate (“&agr;-HIV”) utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including &agr;-HIV.
    Type: Application
    Filed: July 18, 2003
    Publication date: March 11, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Bacterial strains which overproduce riboflavin
    Publication number: 20030232406
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Application
    Filed: February 10, 2003
    Publication date: December 18, 2003
    Applicant: ROCHE VITAMINS, INC.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Nutrient medium for bacterial strains which overproduce riboflavin
    Patent number: 6551813
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: April 22, 2003
    Assignee: Roche Vitamins Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • OVERCOMING DAPA AMINOTRANSFERASE BOTTLENECKS IN BIOTIN VITAMERS BIOSYNTHESIS
    Publication number: 20020098556
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Application
    Filed: July 14, 1997
    Publication date: July 25, 2002
    Inventors: SCOTT W. VAN ARSDELL, R. ROGERS YOCUM, JOHN B. PERKINS, JANICE G. PERO
  • Biotin biosynthesis in bacillus subtilis
    Patent number: 6303377
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: October 16, 2001
    Assignee: Roche Vitamins Inc.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
  • Biotin biosynthesis in Bacillus subtilis
    Patent number: 6057136
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: May 2, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
  • Bacterial strains which overproduce riboflavin
    Patent number: 5925538
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: July 20, 1999
    Assignee: Roche Vitamins Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero, Randolph T. Hatch, Theron Hermann, Thomas Erdenberger
  • Bacterial strains which overproduce riboflavin
    Patent number: 5837528
    Abstract: Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at multiple sites and in multiple copies per site. A rib operon having at least five genes is used to make such recombinant bacteria.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: November 17, 1998
    Assignee: Hoffmann La Roche, Inc.
    Inventors: John B. Perkins, Alan Sloma, Janice G. Pero
  • Secretion vector
    Patent number: 4769327
    Abstract: A vector including a DNA sequence encoding a secretory signal sequence substantially identical to the secretory signal encoding sequence of the Bacillus licheniformis .alpha.-amylase gene; upstream from the signal-encoding sequence, a promoter sequence and a ribosome binding site sequence, transcription of the signal-encoding sequence being under the control of the promoter sequence; and downstream from the signal-encoding sequence, a site for the insertion into the vector of a heterologous DNA sequence, in reading frame with the signal-encoding sequence.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: September 6, 1988
    Assignee: Biotechnica International, Inc.
    Inventors: Michael A. Stephens, Cathy F. Rudolph, Nancy M. Hannett, Diane L. Stassi, Janice G. Pero