Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: A method for operating a search engine may include determining a multi-dimensional search parameter space comprising a set of possible weight values for each of a plurality of search parameters and dividing the search parameter space into a grid of evenly-spaced values that is a subset of the set of possible values. The method may further include defining one or more initial populations of search parameter weight values, wherein each population of search parameter weight values comprises a plurality of initial individuals, wherein each initial individual comprises a respective one of the evenly-spaced values for each of the search parameters. The method may further include executing one or more genetic algorithms based on the one or more initial populations to select a final set of search parameter weight values, and returning results of a user search in the search engine according to the final set of search parameter weight values.

Abstract: A method for operating a search engine may include determining a multi-dimensional search parameter space comprising a set of possible weight values for each of a plurality of search parameters and dividing the search parameter space into a grid of evenly-spaced values that is a subset of the set of possible values. The method may further include defining one or more initial populations of search parameter weight values, wherein each population of search parameter weight values comprises a plurality of initial individuals, wherein each initial individual comprises a respective one of the evenly-spaced values for each of the search parameters. The method may further include executing one or more genetic algorithms based on the one or more initial populations to select a final set of search parameter weight values, and returning results of a user search in the search engine according to the final set of search parameter weight values.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Controlling traffic signal preemption includes inputting to a conditional preemption circuit, values of incident parameters that include at least a vehicle unit identifier of a vehicle unit and an incident priority that describes an incident. The conditional preemption circuit determines a vehicle class based on one or more of the plurality of incident parameters. In response to a preemption request communicated from the vehicle unit, the conditional preemption circuit determines whether or not the vehicle unit qualifies for preemption at one or more intersections based at least on the vehicle class, location of the vehicle, and heading of the vehicle unit specified in the preemption request. Phase selection signals are communicated to traffic signal control circuitry at the one or more intersections in response to determining that the vehicle unit qualifies for preemption at the one or more intersections.

Abstract: A method of generating images of a specimen that includes triggering a source of electromagnetic radiation to emit a beam of electromagnetic radiation along an axis through a tissue specimen and towards an imaging detector, generating at least one image with the received beam at the imaging detector, and superimposing, into or adjacent the at least one image by a system controller, a set of graphical indications that convey portions of a patient's body from which respective portions of the specimen were assumed to have been excised.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.