Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: An autonomous floor cleaner includes multiple occupiable space sensors for position and/or proximity sensing. Data from the occupiable space sensors can be used determine areas of occupiable space in proximity to the autonomous floor cleaner. Methods for exiting a trapped condition, obstacle avoidance, and path planning are disclosed.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A docking station for charging an autonomous floor cleaner includes a transmitter that can transmit a signal for detection by the robot. The docking station can include an opaque shroud for the transmitter and/or spring-loaded charging contacts. The autonomous floor cleaner can comprise a passive receiver that detects signals emitted from the docking station and a time-of-flight sensor for position/proximity sensing. The robot can selectively turn off the time-of-flight sensor when docking with or avoiding the docking station. Methods for docking, re-docking, low power charging, docking station avoidance, obstacle response during docking, and close-proximity docking are disclosed.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A docking station for charging an autonomous floor cleaner includes a transmitter that can transmit a signal for detection by the robot. The docking station can include an opaque shroud for the transmitter and/or spring-loaded charging contacts. The autonomous floor cleaner can comprise a passive receiver that detects signals emitted from the docking station and a time-of-flight sensor for position/proximity sensing. The robot can selectively turn off the time-of-flight sensor when docking with or avoiding the docking station. Methods for docking, re-docking, low power charging, docking station avoidance, obstacle response during docking, and close-proximity docking are disclosed.

Abstract: An autonomous floor cleaner includes multiple occupiable space sensors for position and/or proximity sensing. Data from the occupiable space sensors can be used determine areas of occupiable space in proximity to the autonomous floor cleaner. Methods for exiting a trapped condition, obstacle avoidance, and path planning are disclosed.

Abstract: A system and method for communicatively pairing a mobile communication device and a furniture item, such as a desk or table, includes placing the mobile communication device in a communication zone associated with the furniture item. In response to placing the mobile communication device in the communication zone, a communication link is established between the mobile communication device and a communication circuit of the furniture item. A user interface is then displayed on a display screen of the mobile communication device to show a preset height, such as a standing or sitting height, for the furniture device. When a user selects the preset height, an actuator adjusts the furniture item to the specific height. The communication circuit may use any available wireless communication protocol or circuit.

Abstract: A system and method for communicatively pairing a mobile communication device and a furniture item, such as a desk or table, includes placing the mobile communication device in a communication zone associated with the furniture item. In response to placing the mobile communication device in the communication zone, a communication link is established between the mobile communication device and a communication circuit of the furniture item. A user interface is then displayed on a display screen of the mobile communication device to show a preset height, such as a standing or sitting height, for the furniture device. When a user selects the preset height, an actuator adjusts the furniture item to the specific height. The communication circuit may use any available wireless communication protocol or circuit.

Abstract: A method of communicatively pairing a first furnishing item with a second furnishing item, the method including impacting the first furnishing item against the second furnishing item. The method also includes generating a first output with a first sensor of the first furnishing item in response to an impact between the first furnishing item and the second furnishing item and generating a second output with a second sensor of the second furnishing item in response to the impact between the first furnishing item and the second furnishing item. The method further includes receiving, by a controller, the first output, receiving, by the controller, the second output, and pairing a first communication circuit of the first furnishing item with a second communication circuit of the second furnishing item in response to receiving the second output within a predetermined time of receiving the first output.

Abstract: A method of communicatively pairing a first furnishing item with a second furnishing item, the method including impacting the first furnishing item against the second furnishing item. The method also includes generating a first output with a first sensor of the first furnishing item in response to an impact between the first furnishing item and the second furnishing item and generating a second output with a second sensor of the second furnishing item in response to the impact between the first furnishing item and the second furnishing item. The method further includes receiving, by a controller, the first output, receiving, by the controller, the second output, and pairing a first communication circuit of the first furnishing item with a second communication circuit of the second furnishing item in response to receiving the second output within a predetermined time of receiving the first output.

Abstract: A method of operating a desk including receiving, at a desk controller, a message from a chair, and determining a position of a user based on the message. The message includes an indication of a sensed rotation of the chair. The method also includes generating, via the desk controller, a control signal for a motor based on the position of the user. The motor is coupled to a support framework of the desk. The method further includes changing a height of the support framework of the desk according to the control signal.

Abstract: Plasmid vectors and use of plasmid vectors in methods for producing methane and isoprene using Archaea are disclosed. Particularly, plasmid vectors that express isoprene synthase (ispS) are prepared and inserted into methanogens, such as Methanosarcina acetivorans, to allow for co-production of methane and isoprene. In one embodiment, the methods of the present disclosure can be used for wastewater management.

Abstract: A method of operating a desk including receiving, at a desk controller, a message from a chair, and determining a position of a user based on the message. The message includes an indication of a sensed rotation of the chair. The method also includes generating, via the desk controller, a control signal for a motor based on the position of the user. The motor is coupled to a support framework of the desk. The method further includes changing a height of the support framework of the desk according to the control signal.

Abstract: A portable treestand for hunters includes a one piece supporting platform, seat and post molded from a light weight thermoplastic material. The unitary construction of the platform and seat eliminates a large number of fabrication steps and related fastening techniques and devices used therewith. As a result, the platform and seat are stronger, lighter and more rigid, free from many potentially movable joints, and may be made with an irregular pattern.

Abstract: Plasmid vectors and use of plasmid vectors in methods for producing methane and isoprene using Archaea are disclosed. Particularly, plasmid vectors that express isoprene synthase (ispS) are prepared and inserted into methanogens, such as Methanosarcina acetivorans, to allow for co-production of methane and isoprene. In one embodiment, the methods of the present disclosure can be used for wastewater management.

Abstract: An approach is provided for detecting and monitoring end user license agreement (EULA) compliance is provided. A request to access a executable software code is received from an end user. A EULA version corresponding to the requested executable software code is identified. A determination is made as to whether the end user has accepted the identified EULA. If the end user has not accepted the identified EULA, then an out of date EULA notification is sent to the end user, the EULA is sent to the end user requesting an acceptance to the EULA. A EULA response is received from the end user. If the end user accepts the EULA, then the end user is allowed access to the executable software code.

Abstract: Described here are devices and methods for strengthening the thenar muscles of the hand. Generally, a device comprises a base shaped to be held in the hand, a thumb rest having a hinge attached to the base such that one end of the thumb rest can be pivoted relative to the base, and an elastic member attached to the base and the thumb rest, which resists the pivoting motion of the thumb rest relative to the base. The user can place the device in his or her hand, and place his or her thumb on the thumb rest. When the user presses the thumb rest toward the base with his or her thumb, the elastic member supplies a force resisting the pressing motion, which exercises the thenar muscles.