Patents by Inventor Jaroslav A. Kralovec

Jaroslav A. Kralovec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230304050
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition. The process comprises a) hydrolysis of the glyceride by Thermomyces lanuginosus lipase, b) separation of the free saturated fatty acids from the glycerides and c) enzymatic esterification of the hydrolyzed glyceride by Candida antarctica lipase B with a polyunsaturated fatty acid.
    Type: Application
    Filed: April 11, 2023
    Publication date: September 28, 2023
    Inventors: Jaroslav A. KRALOVEC, Weijie WANG, James Colin BARROW
  • Patent number: 11649473
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: May 16, 2023
    Assignee: DSM Nutritional Products AG
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Patent number: 11466231
    Abstract: A method for producing diglycerides is provided. The method includes combining (i) an oil comprising at least one polyunsaturated fatty acid in the form of ethyl esters, free fatty acids, and/or combinations thereof, (ii) lipase, and (iii) glycerol in water to produce diglycerides with a high level of purity. Highly pure diglycerides obtained according to the method are also provided.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: October 11, 2022
    Assignee: DSM IP Assets B.V.
    Inventors: Jaroslav A. Kralovec, Paul Frederick Mugford, Alfred Rolle
  • Publication number: 20210369668
    Abstract: A composition comprising ?-tocopherol acetate (also referred to as Vitamin E acetate “Vit E Acetate”) and docosahexaenoic acid ethyl ester (“DHA EE”), exhibits surprising oxidative stability.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 2, 2021
    Inventors: Weerasinghe M. INDRASENA, Jaroslav A. KRALOVEC, Bernd MUSSLER
  • Publication number: 20210238499
    Abstract: A method for producing diglycerides is provided. The method includes combining (i) an oil comprising at least one polyunsaturated fatty acid in the form of ethyl esters, free fatty acids, and/or combinations thereof, (ii) lipase, and (iii) glycerol in water to produce diglycerides with a high level of purity. Highly pure diglycerides obtained according to the method are also provided.
    Type: Application
    Filed: June 4, 2019
    Publication date: August 5, 2021
    Inventors: Jaroslav A. KRALOVEC, Paul Frederick MUGFORD, Alfred ROLLE
  • Publication number: 20200369982
    Abstract: The present invention relates to oil compositions that are enriched in polyunsaturated fatty acids; compositions containing the oil compositions; and methods of making and using the oil compositions. The oil is preferably a microbial or marine oil.
    Type: Application
    Filed: August 6, 2018
    Publication date: November 26, 2020
    Inventors: Jaroslav KRALOVEC, Erick REYES-SUAREZ
  • Patent number: 10682334
    Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: June 16, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Szabolcs Peter, Joseph Schwager, Weerasinghe M. Indrasena, Jaroslav A. Kralovec, Bernd Mussler
  • Publication number: 20190345524
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Application
    Filed: July 29, 2019
    Publication date: November 14, 2019
    Inventors: Jaroslav A. KRALOVEC, Weijie WANG, James Colin BARROW
  • Patent number: 10415065
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 17, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Publication number: 20190071618
    Abstract: The present invention is directed to oil compositions that are enriched in polyunsaturated fatty acids; compositions containing the enriched oil compositions; and methods of making and using the enriched oil compositions. The oil is preferably a microbial or marine oil.
    Type: Application
    Filed: October 5, 2016
    Publication date: March 7, 2019
    Inventor: Jaroslav KRALOVEC
  • Publication number: 20190054063
    Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 21, 2019
    Inventors: Szabolcs PETER, Joseph SCHWAGER, Weerasinghe M. INDRASENA, Jaroslav A. KRALOVEC, Bernd MUSSLER
  • Publication number: 20180142272
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Application
    Filed: January 5, 2018
    Publication date: May 24, 2018
    Inventors: Jaroslav A. KRALOVEC, Weijie WANG, James Colin BARROW
  • Patent number: 9885068
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: February 6, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Patent number: 8951761
    Abstract: The disclosed matter relates to immobilized enzymes and methods of use thereof.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: February 10, 2015
    Assignee: DSM Nutritional Products AG
    Inventors: Jaroslav A. Kralovec, Weijie Wang
  • Patent number: 8420349
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: April 16, 2013
    Assignee: Ocean Nutrition Canada Limited
    Inventors: Jaroslav A. Kralovec, Weijie Wang, Colin James Barrow
  • Publication number: 20110104189
    Abstract: The disclosed subject matter, in one aspect, relates to compounds and compositions {e.g., polysaccharides and polysaccharide complexes) and methods for providing and using such compounds and compositions. Disclosed are compositions comprising a polysaccharide or polysaccharide complex obtained from Chlorella, wherein the polysaccharide or polysaccharide complex has a molecular weight of from about 1×103 to about 1×106 Da. Also disclosed are methods of providing a polysaccharide or polysaccharide complex, comprising the steps of providing a Chlorella extract, contacting the extract with a solvent to provide a precipitate, contacting the precipitate with additional substances {e.g., a surfactant) and isolating an insoluble fraction, and size fractioning the insoluble fraction, thereby providing the polysaccharide or polysaccharide complex. Disclosed are also methods for using the disclosed polysaccharide and polysaccharide compositions.
    Type: Application
    Filed: May 6, 2009
    Publication date: May 5, 2011
    Applicant: Ocean Nutrition Canada Limited
    Inventors: Erick Reyes Suarez, Jaroslav Kralovec, T. Bruce Grindley, Colin Barrow
  • Publication number: 20110045555
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Application
    Filed: July 11, 2008
    Publication date: February 24, 2011
    Inventors: Jaroslav A. Kralovec, Weijie Wang, Colin James Barrow
  • Publication number: 20100041111
    Abstract: The disclosed matter relates to immobilized enzymes and methods of use thereof.
    Type: Application
    Filed: June 13, 2006
    Publication date: February 18, 2010
    Inventors: Jaroslav A. Kralovec, Weijie Wang
  • Publication number: 20090182050
    Abstract: Disclosed are methods of making salts of fatty acids (e.g., marine oils) and to salts prepared by the disclosed methods. Methods of using the disclosed salts are also disclosed.
    Type: Application
    Filed: October 3, 2006
    Publication date: July 16, 2009
    Inventors: Colin Barrow, Jaroslav A. Kralovec
  • Patent number: 7504115
    Abstract: Disclosed is a composition from shark cartilage comprising immunoactive proteoglycans and other immunoactive components having a molecular weight greater than about 100 KD, wherein the composition has a uronic acid content of about 0.05-0.5 ?g glucuronic acid per ?g of the composition. The composition may be useful for treating or preventing tumor growth, bacterial infections, viral infections and/or fungal infections.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: March 17, 2009
    Assignee: Ocean Nutrition Canada Limited
    Inventors: Jaroslav A. Kralovec, Frank Chung-Yin Sing