Patents by Inventor Jasbir Seehra

Jasbir Seehra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRUNCATED ACTRIIB-FC FUSION PROTEINS
    Publication number: 20200157512
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue.
    Type: Application
    Filed: June 7, 2019
    Publication date: May 21, 2020
    Inventors: Jasbir Seehra, Ravindra Kumar
  • METHODS FOR INCREASING THERMOGENIC ADIPOCYTES
    Publication number: 20200148788
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
    Type: Application
    Filed: June 12, 2019
    Publication date: May 14, 2020
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR
    Publication number: 20200071381
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Application
    Filed: February 27, 2019
    Publication date: March 5, 2020
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • ACTRIIB-FC POLYNUCLEOTIDES, POLYPEPTIDES, AND COMPOSITIONS
    Publication number: 20190352619
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRII protein and/or an ActRII ligand.
    Type: Application
    Filed: December 17, 2018
    Publication date: November 21, 2019
    Inventors: John Knopf, Jasbir Seehra
  • COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE RED BLOOD CELL LEVELS
    Publication number: 20190263876
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 29, 2019
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • Methods of identifying ActRIIB variants
    Patent number: 10377996
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: August 13, 2019
    Assignee: ACCELERON PHARMA INC.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • ANTAGONISTS OF ACTIVIN-ACTRIIA AND USES FOR INCREASING RED BLOOD CELL LEVELS
    Publication number: 20190225664
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: September 4, 2018
    Publication date: July 25, 2019
    Inventors: Matthew L. Sherman, Jasbir Seehra, Niels Borgstein
  • Method for producing an ActRIIB-Fc fusion polypeptide
    Patent number: 10358633
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 23, 2019
    Assignee: ACCELERON PHARMA INC.
    Inventors: Jasbir Seehra, Ravindra Kumar
  • METHOD FOR PROMOTING BONE GROWTH USING ACTIVIN-ACTRIIA ANTAGONISTS
    Publication number: 20190192625
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Application
    Filed: August 3, 2018
    Publication date: June 27, 2019
    Inventors: John Knopf, Jasbir Seehra
  • Variants derived from ActRIIB and uses therefor
    Patent number: 10259861
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: April 16, 2019
    Assignee: ACCELERON PHARMA INC.
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • Method of promoting bone growth by an anti-actriia antibody
    Patent number: 10239940
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 26, 2019
    Assignee: ACCELERON PHARMA INC.
    Inventors: John Knopf, Jasbir Seehra
  • METHODS FOR TREATING FATTY LIVER DISEASE
    Publication number: 20190062392
    Abstract: In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies and anti-activin A or B antibodies. A variety of hepatic and metabolic disorders may be improved by treating fatty liver disease.
    Type: Application
    Filed: March 19, 2018
    Publication date: February 28, 2019
    Inventors: Alan Koncarevic, Jennifer Lachey, Jasbir Seehra, Matthew L. Sherman
  • METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS AND PERICYTE COMPOSITION
    Publication number: 20190048063
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 14, 2019
    Applicants: Acceleron Pharma Inc., Ludwig Institute for Cancer Research Ltd.
    Inventors: Asya Grinberg, John Knopf, Robert S. Pearsall, Ravindra Kumar, Jasbir Seehra, Kristian Pietras
  • Methods for treating refractory anemia with ringed sideroblasts
    Patent number: 10131700
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: November 20, 2018
    Assignee: ACCELERON PHARMA INC.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • METHODS FOR TREATING REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS
    Publication number: 20180312559
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: October 23, 2017
    Publication date: November 1, 2018
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • BMP-ALK3 ANTAGONISTS AND USES FOR PROMOTING BONE GROWTH
    Publication number: 20180305438
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention provides ALK3 polypeptides, including ALK3-Fc fusion proteins.
    Type: Application
    Filed: February 8, 2018
    Publication date: October 25, 2018
    Applicant: Acceleron Pharma Inc.
    Inventor: Jasbir Seehra
  • Antagonists of activin-ActRIIa and uses for increasing red blood cell levels
    Patent number: 10093707
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: October 9, 2018
    Assignee: ACCELERON PHARMA INC.
    Inventors: Matthew L. Sherman, Jasbir Seehra, Niels Borgstein
  • Method of identifying an agent that promotes bone growth or increases bone density
    Patent number: 10071135
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 11, 2018
    Assignee: ACCELERON PHARMA INC.
    Inventors: John Knopf, Jasbir Seehra
  • Compositions comprising ALK1-ECD protein
    Patent number: 10059756
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: August 28, 2018
    Assignee: Acceleron Pharma Inc.
    Inventors: Asya Grinberg, John Knopf, Robert S. Pearsall, Ravindra Kumar, Jasbir Seehra, Kristian Pietras
  • ACTRIIB ANTAGONISTS AND DOSING AND USES THEREOF
    Publication number: 20180194828
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting hone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist are also provided.
    Type: Application
    Filed: November 13, 2017
    Publication date: July 12, 2018
    Inventors: Jasbir Seehra, John Knopf, Kenneth M. Attie