Patents by Inventor Jasbir Seehra

Jasbir Seehra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS AND PERICYTE COMPOSITION
    Publication number: 20180179293
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
    Type: Application
    Filed: February 13, 2018
    Publication date: June 28, 2018
    Applicants: Ludwig Institute for Cancer Research Ltd., Acceleron Pharma, Inc.
    Inventors: Asya Grinberg, John Knopf, Robert S. Pearsall, Ravindra Kumar, Jasbir Seehra, Kristian Pietras
  • METHODS FOR INCREASING THERMOGENIC ADIPOCYTES
    Publication number: 20180162954
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
    Type: Application
    Filed: September 13, 2017
    Publication date: June 14, 2018
    Applicant: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • Isolated nucleotide sequences encoding GDF traps
    Patent number: 9932379
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 3, 2018
    Assignee: ACCELERON PHARMA INC.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • METHOD FOR DECREASING THE BODY FAT CONTENT IN A SUBJECT BY ADMINISTERING AN ACTRIIB PROTEIN
    Publication number: 20180080012
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue.
    Type: Application
    Filed: July 31, 2017
    Publication date: March 22, 2018
    Inventors: Jasbir Seehra, Ravindra Kumar
  • BMP-ALK3 antagonists and uses for promoting bone growth
    Patent number: 9914762
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention provides ALK3 polypeptides, including ALK3-Fc fusion proteins.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: March 13, 2018
    Assignee: ACCELERON PHARMA INC.
    Inventor: Jasbir Seehra
  • METHODS FOR TREATING REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS
    Publication number: 20180037622
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 8, 2018
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • ANTAGONISTS OF ACTRIIB AND USES FOR INCREASING RED BLOOD CELL LEVELS
    Publication number: 20180009872
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 11, 2018
    Inventors: Matthew L. Sherman, Jasbir Seehra, Niels Borgstein
  • ALK1 RECEPTOR AND LIGAND ANTAGONISTS AND USES THEREOF
    Publication number: 20170354731
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.
    Type: Application
    Filed: August 25, 2017
    Publication date: December 14, 2017
    Inventors: ASYA GRINBERG, John Knopf, Robert S. Pearsall, Ravindra Kumar, Jasbir Seehra
  • METHODS AND COMPOSITIONS FOR TREATING INEFFECTIVE ERYTHROPOIESIS
    Publication number: 20170327800
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: July 28, 2017
    Publication date: November 16, 2017
    Applicants: Acceleron Pharma Inc., Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar, Naga Venkata Sai Rajasekhar Suragani
  • ACTRIIB PROTEINS AND VARIANTS AND USES THEREFORE RELATING TO UTROPHIN INDUCTION FOR MUSCULAR DYSTROPHY THERAPY
    Publication number: 20170320925
    Abstract: In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Application
    Filed: March 15, 2017
    Publication date: November 9, 2017
    Inventors: Jasbir Seehra, Jennifer Lachey
  • Methods for increasing thermogenic adipocytes
    Patent number: 9790284
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Noda1, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: October 17, 2017
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • Method for decreasing the body fat content in a subject by administering an ActRIIB protein
    Patent number: 9745559
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, brown fat and/or neuronal tissue and for treating metabolic disorders such as diabetes and obesity, as well as disorders associated with any of the foregoing tissue.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: August 29, 2017
    Assignee: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Ravindra Kumar
  • ISOLATED GDF TRAP POLYPEPTIDE
    Publication number: 20170204382
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: October 27, 2016
    Publication date: July 20, 2017
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • ACTIVIN-ACTRIIA ANTAGONISTS AND USES FOR TREATING MULTIPLE MYELOMA
    Publication number: 20170190784
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
    Type: Application
    Filed: January 11, 2017
    Publication date: July 6, 2017
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • METHOD OF PROMOTING BONE GROWTH BY AN ANTI-ACTRIIA ANTIBODY
    Publication number: 20170145085
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Application
    Filed: September 28, 2016
    Publication date: May 25, 2017
    Inventors: John Knopf, Jasbir Seehra
  • ACTIVIN-ACTRIIA ANTAGONISTS AND USES FOR TREATING OR PREVENTING BREAST CANCER
    Publication number: 20170145074
    Abstract: In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.
    Type: Application
    Filed: November 30, 2016
    Publication date: May 25, 2017
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • ANTAGONISTS OF BMP9, BMP10, ALK1 AND OTHER ALK1 LIGANDS, AND USES THEREOF
    Publication number: 20170137503
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
    Type: Application
    Filed: August 24, 2016
    Publication date: May 18, 2017
    Inventors: JASBIR SEEHRA, John Knopf, Robert S. Pearsall, Asya Grinberg, Ravindra Kumar
  • METHODS AND COMPOSITIONS FOR TREATING INEFFECTIVE ERYTHROPOIESIS
    Publication number: 20170137791
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 18, 2017
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar, Naga Venkata Sai Rajasekhar Suragani
  • ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
    Patent number: 9617319
    Abstract: In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: April 11, 2017
    Assignee: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Jennifer Lachey
  • VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR
    Publication number: 20170058016
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Application
    Filed: July 1, 2016
    Publication date: March 2, 2017
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar