Abstract: A computing system record security architecture comprises, in one example, a record generation component configured to generate a record in a computing system, the record identifying a set of users associated with the record, and having an owner property that identifies a first user as an owner of the record, a co-owner assignment component configured to receive a co-owner assignment request, from the first user, to assign a second user to the record as a co-owner, and a record security component configured to receive a record modification request, from the second user, that requests a modification to the record, and to propagate the record modification request to the set of users with a unique identifier that identifies the first user.

Abstract: Providing series level updates for a series. A method includes identifying a master message. The master message is a series level message that includes a plurality of default properties for an ordered series. An ordered series of instance messages related to the series level message is identified. For each instance message in the ordered series of instance messages, one or more properties are identified that are not yet defined with default property values from the master message and that have not been defined as valid exceptions to the default properties from the master message. A default property value from a corresponding property of the master message is propagated to each of the identified properties. The ordered series is propagated to one or more legacy clients that are unable to consume certain series level messages by propagating the ordered series of instance messages with the updated property values.

Abstract: A method includes identifying a series of events formatted for a modern system. The series of events includes a master message usable by modern systems. The master message includes default information for all events in the series. The method further includes identifying a plurality of instance messages. Each of the instance messages includes default information and exception information for a given event in the series of events. The method further includes sending both the master message and the instance messages to other systems without regard to whether the other systems are modern or legacy systems.

Abstract: Large scale system operation may be provided. Upon receiving an action request from a user, a determination may be made as to whether the user requires elevated permissions to perform the action request. In response to determining that the user requires elevated permissions to perform the action request, the action request may be forwarded to a lockbox for evaluation and a permission response may be received from the lockbox.

Abstract: The present invention is directed to, inter alia, methods and kits for the treatment of depression (preferably, treatment resistant depression), or for the treatment of depression in a suicidal patient, and/or for the treatment and/or prevention of suicidality (e.g. suicidal ideations) comprising administering esketamine according to certain dosing regimens.

Abstract: Large scale system operation may be provided. Upon receiving an action request from a user, a determination may be made as to whether the user requires elevated permissions to perform the action request. In response to determining that the user requires elevated permissions to perform the action request, the action request may be forwarded to a lockbox for evaluation and a permission response may be received from the lockbox.

Abstract: The present invention is directed to methods and dosing regimens for the treatment of depression (preferably, treatment resistant depression), for the treatment of depression in a suicidal patient, and/or for the treatment and/or prevention of suicidality (e.g. suicidal ideations) comprising genotyping a patient to determine their Val66Met rs6265 polymorphism in BDNF and administering a ketamine, preferably esketamine, preferably intranasal esketamine, according to a dosing regimen matched to the patient's genotype.

Abstract: Representative embodiments of a distributed processing method of facilitating interactive analytics of streaming data records by receiving the data records at a plurality of distributed computational nodes, establishing and storing dimensions corresponding to attributes of the data records, parsing the streaming data records to identify matches to at least one of the dimensions and based thereon, reducing the number of data records to create a targeted subset of the data, re-distributing the targeted subsets of the streaming data records among the distributed computational nodes in accordance with the dimensions stored on the nodes, updating a database storing measures of the dimensions in accordance with the targeted subsets of the streaming data records, and using the database to respond to a query based on measures associated with one or more of the dimensions.

Abstract: Representative embodiments of a distributed processing method of facilitating interactive analytics of streaming data records by receiving the data records at a plurality of distributed computational nodes, establishing and storing dimensions corresponding to attributes of the data records, parsing the streaming data records to identify matches to at least one of the dimensions and based thereon, reducing the number of data records to create a targeted subset of the data, re-distributing the targeted subsets of the streaming data records among the distributed computational nodes in accordance with the dimensions stored on the nodes, updating a database storing measures of the dimensions in accordance with the targeted subsets of the streaming data records, and using the database to respond to a query based on measures associated with one or more of the dimensions.

Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.

Abstract: A cardinality of an incoming data stream is maintained in real time; the cardinality is maintained in a data structure that is represented by an unsorted list at low cardinalities, a linear counter at medium cardinalities, and a PCSA at high cardinalities. The conversion to the linear counter makes use of the data in the unsorted list, after which that data is discarded. The conversion to the PCSA uses only the data in the linear counter.

Abstract: Representative embodiments of a distributed processing method of facilitating interactive analytics of streaming data records by receiving the data records at a plurality of distributed computational nodes, establishing and storing dimensions corresponding to attributes of the data records, parsing the streaming data records to identify matches to at least one of the dimensions and based thereon, reducing the number of data records to create a targeted subset of the data, re-distributing the targeted subsets of the streaming data records among the distributed computational nodes in accordance with the dimensions stored on the nodes, updating a database storing measures of the dimensions in accordance with the targeted subsets of the streaming data records, and using the database to respond to a query based on measures associated with one or more of the dimensions.

Abstract: Representative embodiments of a distributed processing method of facilitating interactive analytics of streaming data records by receiving the data records at a plurality of distributed computational nodes, establishing and storing dimensions corresponding to attributes of the data records, parsing the streaming data records to identify matches to at least one of the dimensions and based thereon, reducing the number of data records to create a targeted subset of the data, re-distributing the targeted subsets of the streaming data records among the distributed computational nodes in accordance with the dimensions stored on the nodes, updating a database storing measures of the dimensions in accordance with the targeted subsets of the streaming data records, and using the database to respond to a query based on measures associated with one or more of the dimensions.

Abstract: A system is provided for employing an orchestrator to deploy and implement changes to a system. A change request may be a system build, upgrade, and patches for updating a subset of files within the system. The orchestrator may initially perform a security check and a validation check on a received change request. Upon receiving validation and approval, the change request may be deployed and propagated through a series of deployment scopes. The deployment scopes may become increasingly larger to extensively test the applied change before fully implementing the change on the target system. The orchestrator may submit the applied change to a validation component for getting validation of the change within the deployment scope after each applied change within a deployment scope. After the change request has been deployed through the deployment scopes and validated, the change request may be deployed to the target system and fully implemented.

Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.

Abstract: Large scale system operation may be provided. Upon receiving an action request from a user, a determination may be made as to whether the user requires elevated permissions to perform the action request. In response to determining that the user requires elevated permissions to perform the action request, the action request may be forwarded to a lockbox for evaluation and a permission response may be received from the lockbox.

Abstract: A cardinality of an incoming data stream is maintained in real time; the cardinality is maintained in a data structure that is represented by an unsorted list at low cardinalities, a linear counter at medium cardinalities, and a PCSA at high cardinalities. The conversion to the linear counter makes use of the data in the unsorted list, after which that data is discarded. The conversion to the PCSA uses only the data in the linear counter.

Abstract: Single leader provisioning is enabled through a locking mechanism in a directory service environment. A service running in a domain is enabled to take leader role by writing to a shared file maintained at a relative identity (RID) master server. The service taking the leader role is further enabled to extend its role by rewriting to the shared file periodically. Other services may check the file also periodically and remain passive as long as a service has currently the leader role. If the leader service is down and fails to extend its role, another service can take over by writing to the shared file ensuring a single leader in the provisioning service.