Abstract: A system is provided for employing an orchestrator to deploy and implement changes to a system. A change request may be a system build, upgrade, and patches for updating a subset of files within the system. The orchestrator may initially perform a security check and a validation check on a received change request. Upon receiving validation and approval, the change request may be deployed and propagated through a series of deployment scopes. The deployment scopes may become increasingly larger to extensively test the applied change before fully implementing the change on the target system. The orchestrator may submit the applied change to a validation component for getting validation of the change within the deployment scope after each applied change within a deployment scope. After the change request has been deployed through the deployment scopes and validated, the change request may be deployed to the target system and fully implemented.

Abstract: Large scale system operation may be provided. Upon receiving an action request from a user, a determination may be made as to whether the user requires elevated permissions to perform the action request. In response to determining that the user requires elevated permissions to perform the action request, the action request may be forwarded to a lockbox for evaluation and a permission response may be received from the lockbox.

Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.

Abstract: A cardinality of an incoming data stream is maintained in real time; the cardinality is maintained in a data structure that is represented by an unsorted list at low cardinalities, a linear counter at medium cardinalities, and a PCSA at high cardinalities. The conversion to the linear counter makes use of the data in the unsorted list, after which that data is discarded. The conversion to the PCSA uses only the data in the linear counter.

Abstract: Single leader provisioning is enabled through a locking mechanism in a directory service environment. A service running in a domain is enabled to take leader role by writing to a shared file maintained at a relative identity (RID) master server. The service taking the leader role is further enabled to extend its role by rewriting to the shared file periodically. Other services may check the file also periodically and remain passive as long as a service has currently the leader role. If the leader service is down and fails to extend its role, another service can take over by writing to the shared file ensuring a single leader in the provisioning service.