Abstract: Several embodiments of NO releasing compounds are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for treating or preventing microbial infections, or reducing the microbial load of a microbial infection.

Abstract: A system and a method are provided for collaborative data entry and integration. An operation performed by the system and the method include causing a collaborative interface for input to a spreadsheet to be provided via a user interface, receiving a data entry to the spreadsheet via the collaborative interface, validating the received data entry based on one or more validity rules associated with the spreadsheet, capturing a snapshot of the spreadsheet including the validated data entry, and causing at least the validated data entry of the spreadsheet to be integrated into datasets for one or more applications, at least based on the captured snapshot of the spreadsheet.

Abstract: Methods and systems for determining a minimum number of cell line clones necessary to produce a product having a set of target product attributes are disclosed. An example method includes generating at least one cell line capable of expressing a polypeptide; measuring, using one or more analytical instruments, a plurality of measured product attribute values of a plurality of clones of a candidate cell line; receiving inputs, via a user interface, representing a set of target product attribute values for a product; projecting, by one or more processors based upon the plurality of measured values, a minimum number of subject clones of the product using the candidate cell line necessary to produce a subset of the subject clones having product attributes that satisfy one or more conditions associated with the set of target values; and generating the projected minimum number of subject clones of the product using the candidate cell line.

Abstract: A method for monitoring surroundings of a first sensor system. The method includes: providing a temporal sequence of data of the first sensor system for monitoring the surroundings; generating an input tensor including the temporal sequence of data of the first sensor system, for a trained neural network; the neural network being configured and trained to identify, on the basis of the input tensor, at least one subregion of the surroundings, in order to improve the monitoring of the surroundings with the aid of a second sensor system; generating a control signal for the second sensor system with the aid of an output signal of the trained neural network, in order to improve the monitoring of the surroundings in the at least one subregion.

Abstract: Methods and assemblies for attaching leaflets to a frame of a prosthetic heart valve using a connecting skirt are disclosed. As one example, a prosthetic heart valve can include a frame, a valvular structure mounted within the frame and comprising a plurality of leaflets, each leaflet comprising tabs on opposite sides of the leaflet and a cusp edge portion, and a plurality of connecting skirts. Each connecting skirt comprises side base portions and a central portion connected to each of the cusp edge portion of a corresponding leaflet and struts of the frame, each connecting skirt further comprising side extension portions that extend away from the cusp edge portion along a length of the frame, where each side extension portion of each connecting skirt extends across struts of the frame, between cusp edge portions of adjacent leaflets and connects to an adjacent side extension portion of an adjacent connecting skirt.

Abstract: A method is for tracking an object using an environment sensor. The object is represented by an object status. The method includes detecting a sensor value of the environment sensor, predicting a future object status of the object, and updating the object status using a Bayesian filter. The updating includes using an artificial intelligence module (“AI module”). The AI module is trained such that the detected sensor value is associated with the object and the object status of the object is updated based on the predicted future object status of the object and the detected sensor value.

Abstract: A steering apparatus for actively controlling an at least semi-autonomously driven motor vehicle. The steering apparatus includes a steering body having an axis of rotation, a steering wheel handle and a steering wheel canister. The steering wheel handle and the steering wheel canister are rotatably connected to one another about an axis of rotation. An airbag module is arranged within the steering wheel canister, wherein the steering body has an active position and a stowed position, and is movable between these positions. In the active position, the steering body is rotatable about the axis of rotation for active control of a relevant motor vehicle. The airbag module is held in the steering wheel canister in a functionally identical orientation irrespective of the position of the steering body. An increase in the seating and movement freedom of the driver during a (fully) autonomous operation can be realized while maintaining safety.

Abstract: A midfloor module (10, 11) for a motor vehicle has a frame structure (10) with a battery frame (10). The battery frame (10) has multiple battery modules (11), and multiple tank volumes (1, 2, 2+) that can be used optionally for fuel. A motor vehicle that is equipped with such a midfloor module (10, 11) also is provided as well as a method for manufacturing the midfloor module (10,11).

Abstract: A secondary door can be attached to a primary frame of a primary door. At least one anchor mechanism includes a post element attached to the primary frame and an anchor that can be selectively attached to the post element, the anchor includes at least one of and ornamental and a functional element. The secondary door includes a secondary frame, at least one door slab, and at least one hinge coupling the at least one door slab to the secondary frame. A least one hole is formed in the secondary door so that the post element of the anchor mechanism can extend through the at least one hole and the anchor can be attached to the post element to secure the secondary door to the primary frame. The anchor also can be attached to the post when the secondary door is not secured to the primary frame.

Abstract: The present disclosure provides an aluminium alloy strip for lithographic printing plate supports, which has a rolled-in surface topography on one strip surface. Further, a method is disclosed for manufacturing the aluminium alloy strip and a printing plate for lithographic printing, with a printing plate support made of aluminium alloy. The object of proposing an aluminium alloy strip for lithographic printing plate supports is that it provides a long service life in the printing process and is roughened with less charge support entry. This is achieved in that the surface of the aluminium alloy strip has a mean peak number measured perpendicular to the rolling direction of the aluminium alloy strip.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one embodiment, a prosthetic heart valve can include a frame including a plurality of struts forming a plurality of cells of the frame arranged between an inflow end and an outflow end of the frame, a plurality of leaflets arranged within the frame, at least one commissure comprising an attachment member arranged across a selected cell of the plurality of cells of the frame and attached to struts of the frame forming the selected cell, and commissure tabs of two adjacent leaflets coupled to the attachment member, and a radiopaque marker arranged on the attachment member of the commissure. The marker is configured to indicate a location of the commissure of the prosthetic heart valve.

Abstract: This disclosure provides a technology for developing individual proteins for use in industrial processes that include food production. The technology mines sequence data from protein databases by a process that is done partly in silico. Instead of sampling and testing a vast library of compounds, machine learning and implementation narrows the field of functional candidates by predictive modeling based on known protein structure. Candidate proteins that are selected by this analysis are then produced and screened in a high-throughput manner by recombinant expression and testing to determine whether they have a target function. Multiple cycles of the machine learning, database mining, expression, and testing are done to yield potential ingredients suitable for use in the production of foods, cosmetics, agricultural feed, pharmaceutical excipients, and other industrial products.

Abstract: A device includes a display including multiple pixels, each pixel having an optical emitter to provide at least one light beam from an image. The device also includes an optical element to relay light beams from the display to a viewer through an eyebox, the eyebox limiting an area that includes a pupil of the viewer and a varifocal assembly to direct, through the eyebox, light beams having a first and second mutually orthogonal polarization states, according to a desired mode of operation of the device, and associated with a first and second field of view of the image in a focused mode of operation of the device, and an immersive mode of operation of the device, respectively. A memory storing instructions and a processor to execute the instructions to cause the device to perform a method for adjusting between the immersive mode and the focused mode are also provided.

Abstract: An endoprosthesis for implantation within a vessel lumen may include a tubular scaffold formed of one or more interwoven filaments, wherein the tubular scaffold is configured to shift between a radially collapsed configuration and a radially expanded configuration, a polymeric covering secured to the tubular scaffold, and an anti-migration element extending radially outward from the tubular scaffold. The anti-migration element extends helically along at least a portion of the length of the tubular scaffold in a first helical direction. The anti-migration element may include a wire extending along an outer surface of the tubular scaffold. The anti-migration element may include a second polymeric covering disposed over the wire.

Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.

Abstract: Methods, systems, and storage media for facilitating creation of objects for incorporation into artificial reality environments are disclosed. Exemplary implementations may: receive, from a first user, a media representation of an object for incorporation into an artificial reality environment; generate an offer of compensation for creation of the object of the media representation in a format capable of being incorporated into the artificial reality environment; receive, from a second user, acceptance of the offer of compensation; receive an indication that the object of the media representation has been created in the format capable of being incorporated into the artificial reality environment; and cause addition of the created object to a global asset library accessible by a plurality of users.

Abstract: A method and system for generating a geographic atrophy (GA) lesion segmentation mask corresponding to GA lesions in a retina is disclosed herein. In some embodiments, a set of fundus autofluorescence (FAF) images of a retina having one or more geographic atrophy (GA) lesions and one or both of a set of infrared (IR) images of the retina or a set of optical coherence tomography (OCT) images of the retina may be used to generate the GA lesion segmentation mask including one or more GA lesion segments corresponding to the one or more GA lesions in the retina. In some instances, a neural network may be used to generate the GA lesion segmentation mask.

Abstract: Methods of sanitizing, disinfecting, decontaminating, and/or sterilizing surfaces with small molecule NO releasing compounds are disclosed. In some embodiments, the compounds are covalently modified to store and release nitric oxide. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for preventing the spread of microbial infections, such as nocosomial infections.

Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data stored within a tenant database associated with a tenant, wherein the data is encrypted based at least in part on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based at least in part on a TSEK metadata stored in association with the TSEK, determining a top-level key used in connection with encrypting the wrapper key based at least in part on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based at least in part on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database.