Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract: The present invention relates to a process for extraction and freeze-drying of a Berberis extract. More particularly, the invention provides an optimized process for freeze-drying/lyophilization to increase the solubility of the extract into the surfactants for enhanced incorporation into a nano-carrier system. Furthermore, the present invention also relates to a lipid nano-formulation of freeze-dried Berberis extract and process for preparing the same by high-pressure homogenization. The invention also relates to the lipid nano-formulation of freeze-dried Berberis extract for efficient drug delivery, for dermatological and cosmeceutical purposes, for treating diabetes and diabetes associated complications, as a wound healer, as an antimicrobial, as an anti-infective, as an anti-inflammatory agent and as an antioxidant.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve includes a frame including a plurality of struts forming a plurality of cells of the frame arranged between an inflow end and an outflow end of the frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member arranged across a selected cell of the plurality of cells of the frame and commissure tabs of two adjacent leaflets coupled to the attachment member. The valve further includes a radiopaque marker arranged on the attachment member of the commissure within the selected cell.

Abstract: Disclosed are systems and devices for managing wires and cables associated with residential, commercial, industrial, and utility-scale solar panel installations. The system can include wire management clips. Some of the wire management clips described can attach to the sides and tops of rails that are used to mount solar panels. Others can attach to the return flange (i.e., inner lip) of a solar panel frame. The wire management clips that mount to the return flange can be used in both rail and rail-less solar panel assemblies.

Abstract: A controller for controlling an energy discharge from an energy saving device to a power grid. The system includes decision logic to implement a local response responsive to events currently occurring in a power grid and in addition remote commands sent from a remote location.

Abstract: System and method for control area visualization according to certain embodiments. For example, a method includes: receiving object data from a plurality of data sources; identifying a plurality of first objects associated with a first group based at least in part on the object data, each first object of the plurality of first objects being associated with a geospatial location and a buffer area; determining a first control area associated with the first group based at least in part on the geospatial location and the buffer area of each first object of the plurality of first objects; and causing a presentation of the first control area on a display.

Abstract: Provided herein are dynamic adaptive scheduling (DAS) systems. In some embodiments, the DAS systems include a first scheduler, a second scheduler that is slower than the first scheduler, and a runtime preselection classifier that is operably connected to the first scheduler and the second scheduler, which runtime preselection classifier is configured to effect selective use of the first scheduler or the second scheduler to perform a given scheduling task. Related systems, computer readable media, and additional methods are also provided.

Abstract: The present disclosure provides matched gut and peripheral biomarkers to assess, identify and improve therapeutic measures for IBD, in particular ulcerative colitis and Crohn's disease.

Abstract: A sunscreen composition, containing an effective amount of Methylene Blue and/or a hydrate and or a pharmaceutically-acceptable salt thereof; an effective amount of one or more UVA and/or UVB absorbing compounds, with the proviso that Oxybenzone and Octinoxate are excluded; and an excipient base.

Abstract: The present invention provides a hosting system that hosts a plurality of computer executable applications wherein the applications are accessible by a plurality of users registered to use the hosted plurality of applications, the hosting system including a user access module enabling individual users to access the hosting system using personal credentials and upon entering valid personal credentials, users are assigned one or more system personas for use when the user executes a hosted application, where the details of the system persona are used in place of the user's personal details when the hosted application accesses any online service external to the hosting system, a purchasing facility enabling registered users to purchase goods and/or services online with funds managed by the hosting system, the users utilising a system persona when accessing external online services and the hosting system effecting financial transactions for and on behalf of registered users thereby retaining the privacy of user's

Abstract: An optical device includes a first electrode and a medium that includes ferroelectric liquid crystals and chiral dopants. The medium is located adjacent to the first electrode. The optical device may also include a second electrode distinct and separate from the first electrode. The optical device may be used as an optical dimming device, controlling an amount light passing through the optical device based on a voltage gradient provided to the optical device.

Abstract: An apparatus is disclosed, comprising a detector unit comprising a detector configured to detect an actuation action performable via the detector unit to an actuation button of a medical device to cause the medical device to eject at least a portion of a medicament comprised in the medical device. The detector is configured to detect the actuation action based on a detection of a force and/or a touch applied to the detector unit as part of the actuation action. The apparatus further comprises an electric unit connected to the detector and configured to store and/or provide information related to the detected actuation action. Furthermore, an according method and a computer program for controlling this method are disclosed.

Abstract: Disclosed are methods and devices for securing a solar panel racking system to a tile roof, without removing roof tiles. The devices and method in combination may operate under severe weather conditions such as hurricanes, typhoons, and other tropical cyclones. An installer positions a stanchion through a hole in one of the roof tiles in the tile roof and onto a layer of polyurethane foam positioned over a layer of waterproof roof adhesive sealant. The installer extends the threaded fasteners obliquely through the stanchion, the layer of polyurethane foam, and the layer of waterproof roof adhesive sealant into the roof deck. The waterproof adhesive sealant bonds to the roof underlayment and creates a waterproof seal between the threaded fasteners and the roof deck.

Abstract: A system may include a first computing system that may include at least one processor. The at least one processor may receive a request for identification information associated with a user of the first computing device, such that the request is received from a second computing device. The at least one processor may then receive information regarding an entity associated with the second computing device, retrieve data comprising the identification information from a storage component, generate additional data comprising a portion of the identification information based on the information regarding the entity, and send the additional data to the second computing device.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include a frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member comprising a central portion and a flap extending outward from the central portion, the flap folded over a radially outward facing side of the central portion, and the attachment member arranged across a selected cell of the frame. The commissure further comprises commissure tabs of two adjacent leaflets coupled to a radially inward facing side of the central portion, and a radiopaque marker arranged on the flap of the attachment member, between the flap and the radially outward facing side of the central portion.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for performing tip-pooling aggregation and distribution. In some implementations, data is extracted from a plurality of different data sources. The data is normalized to a same format. The normalized data, which is attributed to a remote identifier, is indexed to an identifier representing a same source as the remote identifier. Portions of the normalized data indexed to the same contribution source are allocated to buckets based on a contribution period and a role for the same contribution source and a rule applicable to the contribution period. Portions of the normalized data indexed to different contribution sources are aggregated in the buckets to different contribution sources according to the allocation rule. The aggregated portions of the normalized data are assigned to targets based on assignment rules applicable to the buckets and distribution targets active during the contribution period.

Abstract: This disclosure discusses devices and systems for attaching solar panels to metal roofs. A mounting device has two or more hinge bases that can pivot at various angles about a hinge platform assembly. The hinge platform assembly is optionally widthwise adjustable. The above-mentioned adjustments allow the mounting device to secure solar panels to various types of metal roofs such as flat, corrugated, and trapezoidal. The hinge platform assembly interfaces with various components of the solar panel racking system. The hinge platform assembly includes hinge sleeves that pass into slots within the hinge bases and surround hinge pins that project upward from the hinge bases. This allows the hinge bases to captively rotate about the hinge platform assembly.

Abstract: In an illustrative embodiment, systems and methods are provided for combining disparate data sets gathered from a variety of external resources to produce safety metrics related to healthcare facilities, correlating data elements derived from the data sets to identify variables that impact safety incident risk in a medical facility environment, and normalizing patient outcomes with underlying population wellness data to allow for benchmarking across facilities and/or geographic regions.

Abstract: The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: A system that can be used for suturing implants includes a first automated fixture that can comprise an articulation arm and a target device holder and a second automated fixture configured to operate as a sewing machine to sew material onto the implant. The second automated fixture uses a curved needle to form a stitch without having to release the needle in the process. The second automated fixture can also include a stitch looper that moves in coordination with the curved needle to perform a single-suture or single-thread stitch.