Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: A method of designing a cement slurry may include: (a) selecting a target permeability and a density requirement; (b) inputting the target permeability into a permeability model and generating a proposed cement composition using the permeability model, wherein the proposed cement composition comprises at least a cement and concentration thereof, and a water and concentration thereof such that a cement slurry formed from the proposed cement composition water meet the density requirement; (c) preparing the cement slurry based on the proposed cement composition; and (d) introducing the cement slurry into a wellbore and allowing the cement slurry to set to form a hardened cement.

Abstract: Embodiments relate to cementing operations and, in certain embodiments, to passivated cement accelerators and methods of using passivated cement accelerators in subterranean formations. An embodiment may comprise a method of cementing comprising: providing a cement composition comprising cement, water, and a passivated cement accelerator; and allowing the cement composition to set.

Abstract: A bulk dry cement may comprise a cement; a solid particle; and a liquid resin accelerator, wherein the liquid resin accelerator is disposed on a surface of the solid particle.

Abstract: Compositions for foamed treatment fluids are disclosed. The foamed treatment fluid may comprise a cement, a viscosifying agent, a thixotropic additive, a foaming surfactant, a gas, and water. The foaming surfactant may comprise a polyethylene glycol alkyl ether (C5-C10), sulfate ammonium salt.

Abstract: A method of cementing may include preparing a cement slurry by mixing at least water and a cement dry blend, wherein the cement dry blend comprises a cement and an activated pozzolan; and introducing the cement slurry into a wellbore penetrating a subterranean formation; and allowing the cement slurry to set to form a hardened mass.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to and neutralize the activity of L1-CAM protein. The antibodies of the present technology are useful in methods for detecting and treating a L1-CAM-positive cancer in a subject in need thereof.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: (Formula (I)) wherein X, L, V, R1; R2, R3 and R4, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion.

Abstract: A method of well treatment may include: providing a polymer; correlating performance of the polymer to a least one physical property of the polymer; and preparing a treatment fluid comprising the polymer.

Abstract: Preparing a cement slurry by mixing at least water and a cement dry blend, wherein the cement dry blend comprises a cement and an activated pozzolan; and introducing the cement slurry into a wellbore penetrating a subterranean formation; and allowing the cement slurry to set to form a hardened mass.

Abstract: Provided are methods, compositions, and systems embodying cement compositions and the synergistic effect of lost circulation materials (LCMs) and fluid loss control additives (FLCAs) thereupon for cementing subterranean zones. A method of subterranean well cementing, comprising providing a cement composition comprising a hydraulic cement, a first FLCA, a LCM, and water, wherein the first FLCA comprises a water-soluble polymer with repeating units comprising a 5- to 6-membered cyclic amide; introducing the cement composition into a wellbore penetrating a subterranean formation, wherein inclusion of the first FLCA and the LCM in the cement composition fluid reduces fluid loss into the subterranean formation, wherein the subterranean formation has fractures with a width of from about 1 micron to about 800 microns, and wherein the subterranean formation has a permeability of about 1 millidarcy to about 300 Darcy; and allowing the cement composition to set in the subterranean formation.

Abstract: A computer system generates a computer-guided personal care routine based at least in part on a digital model of a user's face. In an embodiment, a computer system generates the model based on one or more images or scans of the user's face, and generates a computer-guided personal care routine based on the model, environmental data (e.g., temperature data, humidity data, pollution data, UV radiation data), and user data. In an embodiment, a routine generated on this basis includes multiple steps to be carried out using a computer-controlled skin care device as well as user prompts related to execution of such steps that are configured to be presented in a user interface. In an embodiment, the computer-guided routine includes one or more operational settings (e.g., brush head speed, cleansing duration) for the computer-controlled skin care device that are automatically set at appropriate times according to the generated routine.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: wherein X, L, V, R1, R2, R3 and R4, are as defined herein.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: Methods of cementing include providing a geopolymer cement composition that includes a monophase amorphous hydraulic binder material (MAHBM), a metal silicate, an alkaline activator, and a carrier fluid, introducing the geopolymer cement composition into a subterranean formation, and allowing the geopolymer cement composition to set in the subterranean formation. The MAHBM includes silica or alumina core particulates coated with an amorphous calcium silicate hydrate.

Abstract: Systems, methods, and apparatuses of the present disclosure generally relate to dissolvable plugs for separating fluids in a wellbore. A dissolvable plug includes a first end comprising a first fluid barrier. The first fluid barrier includes a polymer film. The dissolvable plug also includes a second end opposite to the first end. The second end comprises a second fluid barrier. The second fluid barrier comprises a polymer film. The dissolvable plug includes a solid structure made of a sand and salt mixture.

Abstract: A method of cementing may include preparing a cement slurry by mixing at least water and a cement dry blend, wherein the cement dry blend comprises a cement and an activated pozzolan; and introducing the cement slurry into a wellbore penetrating a subterranean formation; and allowing the cement slurry to set to form a hardened mass.