Abstract: Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.

Abstract: Described herein are Tz/TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Abstract: Methods of cementing include providing a geopolymer cement composition that includes a monophase amorphous hydraulic binder material (MAHBM), a metal silicate, an alkaline activator, and a carrier fluid, introducing the geopolymer cement composition into a subterranean formation, and allowing the geopolymer cement composition to set in the subterranean formation. The MAHBM includes silica or alumina core particulates coated with an amorphous calcium silicate hydrate.

Abstract: Wellbore cement compositions can be managed based on material characteristics determined from a cement sample. For example, a cement sample can be retrieved from a wellbore. The cement sample can be analyzed using a plurality of sensors to generate a three-dimensional mapping of particles in the cement sample. The three-dimensional mapping can represent three-dimensional spatial relationships between the particles in the cement sample. The three-dimensional mapping can be compared to baseline three-dimensional mappings in a database. The comparison of the three-dimensional mappings can be used to identify at least one material characteristic of the cement sample. Based on the at least one material characteristic of the cement sample, a cement mixture can be prepared or information related to the cement mixture can be output.

Abstract: A composition includes a borehole or pipeline fluid and a delivery molecule, the delivery molecule stable under conditions external to a borehole or pipeline and including a precursor having an end terminating in degradable linkages bonding the precursor to bridged groups and another end terminating in a leaving group, where under in situ conditions in the pipeline or downhole from the borehole surface contact with an initiator acid catalyzes degradation of the degradable linkages and elimination of the leaving group, releasing the precursor and generating an additive from the precursor. A method includes placing the delivery molecule in the borehole or pipeline; and after the placing, contacting the composition with an initiator acid under in situ conditions.

Abstract: Compositions for foamed treatment fluids are disclosed. The foamed treatment fluid may comprise a cement, a viscosifying agent, a thixotropic additive, a foaming surfactant, a gas, and water. The foaming surfactant may comprise a polyethylene glycol alkyl ether (C5-C10), sulfate ammonium salt.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.

Abstract: A method of well treatment may include: providing a polymer; correlating performance of the polymer to a least one physical property of the polymer; and preparing a treatment fluid comprising the polymer.

Abstract: A composition includes a borehole or pipeline fluid and a delivery molecule, the delivery molecule stable under conditions external to a borehole or pipeline and including a precursor having an end terminating in degradable linkages bonding the precursor to bridged groups and another end terminating in a leaving group, where under in situ conditions in the pipeline or downhole from the borehole surface contact with an initiator acid catalyzes degradation of the degradable linkages and elimination of the leaving group, releasing the precursor and generating an additive from the precursor. A method includes placing the delivery molecule in the borehole or pipeline; and after the placing, contacting the composition with an initiator acid under in situ conditions.

Abstract: A generative media pipeline automatically creates a personalized media program that is customized to reflect the specific viewing preferences of at least one individual user. The generative media pipeline obtains user data indicating the viewing preferences associated with the user and optionally the viewing context of the user. A recommendation service within the generative media pipeline provides a set of content options that includes various types of media content corresponding to the viewing preferences. A recipe service within the generative media pipeline obtains a recipe that defines the logical structure of the personalized media program. The recipe service populates the recipe by executing one or more video processing functions with some or all media content included in the content options. The recipe service thereby generates a logically structured and polished personalized media program that is individually tailored to reflect the specific preferences of the user.

Abstract: A media processing engine selectively transcodes only a portion of the media clips to be included in a personalized media program and generates playback data that allows seamless playback of the personalized media program. The media processing engine analyzes initial playback data associated with the media program that indicates the media clips needed to generate the personalized media program. The media processing engine identifies one or more transitions between media clips in the personalized media program and determines specific segments of those media clips that are associated with the identified transition(s). The media processing engine performs transcoding operations with the determined segments of the media clips to generate one or more transition clips. The media processing engine then updates the initial playback data to indicate that the transition clip(s) should be played during the corresponding transition(s) between the associated media clips.

Abstract: The present disclosure provides methods, compositions, and systems embodying cement compositions and the synergistic effect of lost circulation materials (LCMs) and fluid loss control additives (FLCAs) thereupon for cementing subterranean zones. A method of subterranean well cementing, comprising providing a cement composition comprising a hydraulic cement, a first FLCA, an LCM, and water, wherein the first FLCA comprises a water-soluble polymer with repeating units comprising a 5- to 6-membered cyclic amide; introducing the cement composition into a wellbore penetrating a subterranean formation, wherein inclusion of the first FLCA and the LCM in the cement composition fluid reduces fluid loss into the subterranean formation, wherein the subterranean formation has fractures with a width of from about 1 micron to about 800 microns, and wherein the subterranean formation has a permeability of about 1 milliDarcy to about 300 Darcy; and allowing the cement composition to set in the subterranean formation.

Abstract: Methods and compositions for a foamed treatment fluid in a wellbore. A method of treating a lost circulation zone comprising: introducing a foamed treatment fluid into a lost circulation zone in a subterranean formation, wherein the foamed treatment fluid comprises: a cement; a viscosifying agent; a thixotropic additive; a foaming surfactant; a gas; and water; allowing the foamed treatment fluid to set in the lost circulation zone to seal the lost circulation zone. A foamed treatment fluid comprising: a cement; a viscosifying agent; a thixotropic additive; a foaming surfactant; a gas; and water.

Abstract: Disclosed herein are methods and compositions for cementing. An example method may comprise providing a cement composition. The cement composition may comprise a composite cementitious material comprising a micronized particulate solid and a monophase amorphous hydraulic binder. The micronized particulate solid may have a mean particle size of about 500 microns or less. The cement composition may further comprise water. The method may further comprise introducing the cement composition into a subterranean formation; and allowing the cement composition to set.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: A method of cementing may comprise: providing a bulk dry cement, wherein the bulk dry cement comprises a dry blend of cement and a solid resin accelerator, wherein the solid resin accelerator comprises a liquid resin accelerator on a solid particle; preparing a cement slurry comprising: the bulk dry cement; water; and a liquid hardenable resin component; and introducing the cement slurry into a wellbore.

Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

Abstract: Methods and compositions for a foamed treatment fluid in a wellbore. A method of treating a lost circulation zone comprising: introducing a foamed treatment fluid into a lost circulation zone in a subterranean formation, wherein the foamed treatment fluid comprises: a cement; a viscosifying agent; a thixotropic additive; a foaming surfactant; a gas; and water; allowing the foamed treatment fluid to set in the lost circulation zone to seal the lost circulation zone. A foamed treatment fluid comprising: a cement; a viscosifying agent; a thixotropic additive; a foaming surfactant; a gas; and water.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.