Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Abstract: The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides polyisocyanates, methods of making the polyisocyanates from fused bicyclic alcohols, polyurethanes, and methods of making the polyurethanes from the polyisocyanates.

Abstract: A computer-implemented method and system for authenticating identification of a customer during interaction with a company representative. Data is received and stored relating to the customer at a computer. The data includes one or more identification attributes associated with the customer and one or more authentication data attributes associated with the customer. An interaction is commenced between the customer and the company representative. Captured is one or more identification attributes and authentication data attributes relating to customer from the interaction between the customer and the company representative. The customer is identified by matching a captured identification attribute with a stored identification attribute. The customer is authenticated by matching a captured authentication data attribute with a like stored authentication data attribute associated with the identified customer.

Abstract: The invention described herein provides a flight crew with an easier and more intuitive way to control and monitor flight-control surfaces. Specifically, the invention displays all flight-control surfaces on a touch-screen display device located in an aircraft cockpit. The invention includes graphical and numerical position indicators to continuously display actual position information for flight-control surfaces. Additionally, the invention allows a flight crew to make flight-control surface adjustments through the touch-screen device. The invention further includes an engine performance indicator and a mode controller configured to display autopilot modes and to receive autopilot mode selections. A method is presented for controlling an aircraft flight-control surface via a touch screen device. The method includes receiving an indication of a flight-control surface and enabling selection of a position change.

Abstract: A method of gaming comprising conducting one or more paid game rounds initiated in response to the payment of a wager by a player and a series of one or more free game rounds initiated in response to a free game series trigger event, the method comprising: in each paid game round, selecting a set of paid game round symbols for display to the player, determining a paid game round outcome based on the selected symbols, and incrementing a jackpot by a paid game jackpot increment; in each free game round, selecting a set of free game round symbols for display to the player, determining a free game round outcome based on the selected symbols, and incrementing the jackpot by a free game jackpot increment; and awarding the jackpot on the occurrence of a jackpot award event.

Abstract: An interstitial creator identifies a playlist of media items, the playlist comprising pointers to the media items. The interstitial creator receives a request to insert an interstitial at a location in the playlist, wherein the location is after a first media item and before a second media item. In response to the request, the interstitial creator provides an interstitial creation interface and receives, through the interstitial creation interface, interstitial configuration parameters. The interstitial creator creates the interstitial based on the received interstitial configuration parameters and inserts a pointer to the interstitial into the playlist at the location.

Abstract: Row decoding is performed on row codewords in an array in order to produce a row decoded array that includes row decoded column codewords. Column decoding is performed on the row decoded column codewords in order to produce a row and column decoded array that includes row and column decoded row codewords and row and column decoded column codewords. The number of row and column decoded row codewords that are not in a row codebook is determined and the number of row and column decoded column codewords that are not in a column codebook are determined. If the number not in the row codebook equals 0 and the number not in the column codebook equals 1, at least a data portion of the row and column decoded array is output.

Abstract: Various embodiments include a camera system. The camera system can receive a command to photograph an environment utilizing a camera. The camera system can identify a plurality of flash settings for a flash system of the camera. The camera system can drive the flash system in a sequence of flashes respectively corresponding to the plurality of flash settings. The camera system can then capture consecutive images utilizing the camera. The capturing of the consecutive images can be synchronized against the sequence of flashes such that a device can later combine the consecutive images to generate a composite image that represents a virtual photograph of the environment.

Abstract: In one embodiment, ECG data collected during the long-term monitoring are compressed through a two-step compression algorithm executed by an electrocardiography monitor. Minimum amplitude signals may become indistinguishable from noise if overly inclusive encoding is employed in which voltage ranges are set too wide. The resulting ECG signal will appear “choppy” and uneven with an abrupt slope. The encoding used in the first stage of compression can be dynamically rescaled on-the-fly when the granularity of the encoding is too coarse. In a further embodiment, offloaded ECG signals are automatically gained as appropriate on a recording-by-recording basis to preserve the amplitude relationship between the signals. Raw decompressed ECG signals are filtered for noise content and any gaps in the signals are bridged. An appropriate signal gain is determined based on a statistical evaluation of peak-to-peak voltage (or other indicator) to land as many ECG waveforms within a desired range of display.

Abstract: An interactive computer game is described which works in conjunction with a number of physical modules that a user can connect together in different ways to form a coherent physical whole object. The game receives data from the object via a wireless link, the data identifying at least which modules form part of the object and updates game play based on the data received. At some point within the game play, the game presents an objective or goal to the user which the user can only achieve by interacting with the physical object formed from the modules. In an embodiment, this interaction comprises re-arranging the modules or swapping modules to form an object with a different visual appearance, moving all or part of the object and/or interacting with a sensor on a module in the object. The game may receive further data from the object during the user interaction.

Abstract: A centrifugal pump system having an impeller rotating with first and second magnetic structures on opposite surfaces. A levitation magnetic structure is disposed at a first end of a pump housing having a levitating magnetic field for axially attracting the first magnetic structure. A multiphase magnetic stator at a second end of the pump housing generates a rotating magnetic field for axially and rotationally attracting the second magnetic structure. A commutator circuit provides a plurality of phase voltages to the stator. A sensing circuit determines respective phase currents. A controller calculates successive commanded values for the phase voltages during a running state in response to a desired impeller speed and an actual impeller phase. The controller has a startup interval during which the commanded values of the phase voltages are determined in response to a pseudo impeller phase and in response to a ramping gain factor.

Abstract: A method for setting an engine speed of an internal combustion engine in a marine propulsion device of a marine propulsion system to an engine speed setpoint includes determining the engine speed setpoint based on an operator demand and predicting a position of a throttle valve that is needed to achieve the engine speed setpoint. The method also includes determining a feed forward signal that will move the throttle valve to the predicted position, and after moving the throttle valve to the predicted position, adjusting the engine speed with a feedback controller so as to obtain the engine speed setpoint. An operating state of the marine propulsion system is also determined. Depending on the operating state, the method may include determining limits on an authority of the feedback controller to adjust the engine speed and/or determining whether the operator demand should be modified prior to determining the engine speed setpoint.

Abstract: A modular framing assembly is provided. Each individual module comprises one or more retractable slats that may be extendable to connect with another individual module. The individual modules may be arranged in a plurality of angles and configurations to create frames of varying sizes, shapes and that are capable of bending around corners, where two wall meet.

Abstract: A fiber enforced sheet for use as a wall or floor covering which comprises of adhered thin bricks bonded to a fiber-reinforced, backing layer. Thin brick is adhered to the fiber enforced sheet. The fiber enforced backing increases strength and rigidity to the thin brick during handling, and installation permits the thin bricks to be adhered to proper specification and spacing to be cut using ordinary tile or thin brick tools.

Abstract: A sensor mounting bracket for attachment to a vehicle including a mast configured to support a sensor at a first end, a base pivotably connected to the mast at a second end, a shock absorber attached between the mast and the base, wherein the base is attached to a vehicle and the shock absorber predisposes the mast to either a deployed position or a stowed position.

Abstract: A fuel injector for a gas turbine engine includes a nozzle tip assembly having a substantially monolithically formed nozzle body. The nozzle body has an annular outlet chamber for issuing a spray from the nozzle tip. A feed channel is in fluid communication with the outlet chamber through a feed passage. A heat shield void substantially surrounds the feed channel(s).

Abstract: A grounding rope assembly for electrically grounding a rotatable conductive shaft of a dynamo-electric machine. The assembly includes a grounding rope member including a plurality of conductive wires extending along the length of the grounding rope member and one or more discrete fixation points intermediate the first and second ends of the grounding rope member. Two or more of the plurality of conductive wires are affixed together at each of the discrete fixation points.