Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: A system and method for managing digital identities that in an aspect provides an identity governance service that enables a Web2 architecture user identity to be verifiably linked with a Web3 architecture user identity, and records the verified and signed association of the two identities on a blockchain or similar data block record. Then, either of these digital identities may be employed to execute a digital event or transaction, and where action by an agent of the user may also be taken on behalf of the user in an authentic manner. Recovery of lost digital keys can be achieved in an aspect without reliance on centralized digital authorities.

Abstract: The present disclosure relates to systems, devices, and subsystems for robotic surgeries. The surgical instrument is a robotic attachment that includes an articulation subsystem comprising a rotatable shaft, a distal channel retainer coupled to an end effector that is pivotable about an articulation pivot point, an articulation bushing slidable between a proximal position and a distal position, an articulation rod extending distally from the articulation bushing and coupled at a distal end to the distal channel retainer; and a rack movable with respect to the longitudinal axis of the rotatable shaft. Movement of the rack with respect to the longitudinal axis imparts an axial force onto the articulation bushing moving the articulation bushing between the proximal position and the distal position. Movement of the articulation bushing between the distal position and the proximal position actuates the articulation rod causing the distal channel retainer to pivot about the articulation pivot point.

Abstract: Systems and subsystems for cutting and stapling tissue are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment. The surgical instrument includes a closure subsystem, an articulation subsystem, a roll subsystem, and a transection subsystem that are operable independently of each other.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: Imaging systems and related methods are disclosed. In accordance with an implementation, a system includes a flow cell receptacle to receive a flow cell that receives a sample and an imaging system having a light source assembly, and an imaging device. The light source assembly to form a substantially collimated beam. The optical assembly including an asymmetric beam expander group that includes one or more asymmetric elements or anamorphic elements disposed along an optical axis. The optical assembly to receive the substantially collimated beam from the light source assembly, and transform the substantially collimated beam into a shaped sampling beam having an elongated cross section in a far field at or near a focal plane of the optical assembly to optically probe the sample. The imaging device to obtain image data associated with the sample in response to the optical probing of the sample with the sampling beam.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: Methods, drilling systems, and computer-readable media for evaluating candidate correctional trajectories for a directional drilling well. If the user wishes to investigate alternatives trajectories or trajectories to get a BHA back to a planned trajectory, the computing system allows the user to enter one or more intermediate targets. The computing system generates drilling parameters for the alternative targets and displays them to the user. The user can adjust parameters and intermediate targets, as well as drilling parameters, to investigate a range of possible solutions before selecting an update to the planned trajectory.

Abstract: An intermittent catheter, preferably a female intermittent catheter, is provided in an assembly. The assembly may include a cap which may be attachable to the base of the assembly in use, and/or a seal which misaligns with sealing surfaces of a chamber wall and a moveable insert in use. It may have a two-step deployment, and/or a sheath that pulls out a storage chamber. Internal and external housing may define the storage chamber. The housing may have a filling aperture and/or the storage chamber may comprise an insert configured to move axially in response to rotation.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

Abstract: A method and system that include receiving sensor data that is indicative of an operational status of a well construction equipment that is being utilized to construct a planned well that include receiving a well construction plan that includes information that is indicative of the planned well and the well construction equipment. The method and system additionally include accessing a database of operational sequences that are executable to be performed by the well construction equipment to construct a plurality of wells and selecting from the database an operational sequence to construct the planned well. The method and system further include electronically controlling the well construction equipment to autonomously perform the plurality of physical or mechanical operations of the selected operational sequence to drill at least one of: a selected portion of the planned well and a path along the selected portion of the planned well through a subterranean formation.

Abstract: A supervisory control system for a well construction rig operable to perform well construction operations to construct a planned well at a wellsite. The supervisory control system may be installable in association with the well construction rig. The supervisory control system may comprise a supervisory controller communicatively connectable with a central controller of a rig control system of the well construction rig. The rig control system may be communicatively connected with and operable to control well construction equipment of the well construction rig. The supervisory controller may be operable to control the well construction equipment via the rig control system to cause the well construction equipment to perform the well construction operations. The central controller may be operable as an I/O interface for matching inputs and outputs of the supervisory controller with corresponding inputs and outputs of at least one piece of the well construction equipment.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Abstract: Methods, drilling systems, and computer-readable media for evaluating candidate correctional trajectories for a directional drilling well. If the user wishes to investigate alternatives trajectories or trajectories to get a BHA back to a planned trajectory, the computing system allows the user to enter one or more intermediate targets. The computing system generates drilling parameters for the alternative targets and displays them to the user. The user can adjust parameters and intermediate targets, as well as drilling parameters, to investigate a range of possible solutions before selecting an update to the planned trajectory.

Abstract: Methods, computing systems, and computer-readable media for dynamically presenting different types of data in an interface at different stages of a plan based on the monitoring the progression of the plan. The method includes receiving a selection of a goal for an operation, determining a plan based on the selected goal, determining different types of data to present at different stages of the plan, continuously receiving data representing one or more measurements taken during the operation, identifying a progression of the plan based on the continuously receiving the data, and dynamically presenting the different types of data in an interface at different stages of the plan based on the identifying the progression of the plan. The dynamically presenting the different types of data directs a user's attention to the different types of data relevant at the different stages of the plan.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.