Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Abstract: A method of stimulating a formation containing two or more wellbores includes simultaneously stimulating a first region of each wellbore using a stimulation fluid so as to create a primary fracture in the first region of each wellbore, wherein the first region comprises a first opening or openings allowing fluid communication between each wellbore and the formation, wherein the first region has a first stimulated lateral length and wherein the flow rate of the stimulation fluid through the first opening or openings is greater than 1 barrel per minute per foot of the first stimulated lateral length.

Abstract: A reservoir stimulation tool for stimulating a formation surrounding a wellbore having an inner wall includes: a tubular string including an outer wall defining therein an inner bore, the tubular string being configured to be inserted into the wellbore so as to form an annular space between the tubular string and the inner wall of the wellbore, a plurality of ports formed in the outer wall of the tubular string; a plurality of port valves for opening or closing the ports; and a plurality of packers coupled to the tubular string, wherein each packer is configured to be expanded in order to engage the inner wall of the wellbore, thereby isolating two or more longitudinal segments of the annular space from each other.

Abstract: The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Abstract: The present invention relates to tetrahydropyrido[4,3-d]pyrimidine based compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Abstract: A flat mailing envelope form for encapsulating an insert by an automated paper folding machine, includes a rectangular front panel with a seal flap fold edge, a bottom fold edge opposite the seal flap fold edge, a first side fold edge, and a second side fold edge opposite the first side edge. A back panel extends from the front panel bottom fold edge includes a back panel seal cohesive region, a first wing cohesive region, and a second wing cohesive region. A seal flap extends from the front panel seal flap fold edge includes a seal flap cohesive region configured to mate with the back panel seal cohesive region. First and second wings with cohesive regions extend from the front panel.

Abstract: An HD content acquisition and distribution system includes a central distributor disposed to encode and serve HD content and a plurality of modular packaged content acquisition equipment disposed to be deployed at a live event and in at least partial communication with the central distributor. The content acquisition equipment includes recording equipment, processing equipment, transmission equipment, and communications equipment. The recording equipment includes at least one camera, digital recording device, and digital production device. The processing equipment includes audio/video processing equipment. The transmission equipment includes equipment configured to be interfaced with an existing network for content transmission to the central distributor, and a backup transmission path. The communications equipment includes VOIP equipment configured to allow communication between personnel operating the content acquisition equipment and the central distributor.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: A method of recovering hydrocarbons from a hydrocarbon-bearing subterranean formation with a matrix permeability of less than 1 mD is disclosed. The method includes injecting a volume of a first fluid having a viscosity lower than the viscosity of water into an injection well present in the formation; separately injecting a volume of a second fluid into the formation before, after, or before and after injecting the first fluid; and producing at least a fraction of the injected volume of the first fluid and hydrocarbons from the formation through a production well present in the formation.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

Abstract: System including an excitation assembly that is configured to excite a sample with first and second wavelengths during first and second excitation events, respectively, of an illumination/detection cycle. The sample provides emission light that includes different first, second, third, and fourth spectral patterns in response to the first and second wavelengths. The system also includes a first detection camera that detects the first spectral pattern during a first measurement phase of the illumination/detection cycle. The first detection camera detects the third spectral pattern during a second measurement phase of the illumination/detection cycle. The system also includes a second detection camera that detects the second spectral pattern during the first measurement phase. The second detection camera detects the fourth spectral pattern during the second measurement phase.

Abstract: A detection system including a detection assembly to receive emission light emitted from a sample. The detection assembly has a multi-band dichroic member and at least first and second detection devices. The multi-band dichroic member has a transmission/reflection characteristic with first and second transmissive regions and a reflective region along a wavelength spectrum. The dichroic member transmits portions of the emission light that align with the first and second transmissive regions and reflects a portion of the emission light that aligns with the reflective region. The dichroic member includes a single mirror with an incident surface. The incident surface is configured to transmit the portions of the emission light that align with the first and second transmissive regions and configured to reflect the portion of the emission light that aligns with the reflective region.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: Disclosed are methods and apparatus for accessing data from electronic documents stored as print streams are disclosed. In one embodiment, an electronic document conforming to one of a plurality of print formats is obtained. The electronic document is parsed according to the one of the plurality of print formats to generate an intermediate data structure conforming to an intermediate format such that the electronic document is converted to the intermediate format, wherein the intermediate format is different from the plurality of print formats. One or more rules are applied to obtain data for a plurality of regions of the electronic document from the intermediate data structure. The data for the plurality of regions of the electronic document that has been obtained from the intermediate data structure is stored or provided, thereby enabling a report to be generated using at least a portion of the data for the plurality of regions that has been stored or provided.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.

Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.