Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.

Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.

Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.

Abstract: A gaming device for providing an award to a player is described herein. The gaming device displays a primary game including a plurality of reels and a plurality of symbols displayed with reels, generates an outcome of the primary game, and provides a primary award as a function of the outcome. The gaming device detects a triggering condition occurring with the primary game and responsively displays a secondary game including a game board having a plurality of paths and a plurality of position locations defined along each of the plurality of paths. The gaming device determines a current player position within the game board and responsively displays a player symbol at the current player position. The current player position is associated with one of the plurality of position locations and is indicative of a previous position location of the player symbol at a completion of a previous secondary game.

Abstract: A gaming machine for providing a game to a player is described herein. The gaming machine displays a primary game including a plurality of reels, detects a triggering condition occurring with the primary game and responsively displays a secondary game. The secondary game includes a player character and an enemy character being displayed on an animated game field. The gaming machine randomly selects an enemy strength value associated with the enemy character, randomly selects a player strength value associated with the player character, and determines an outcome of the secondary game including whether the player character defeats the enemy character as a function of the player strength value and the enemy strength value.

Abstract: A gaming machine, a method of controlling a gaming machine, and a computer-readable recording medium storing a program wherein a first game and a second game are related to each other are provided. In a gaming machine, a first area and a second area sharing virtual reel strips are displayed, only the first area is set as a determination area in a first game, and both the first area and the second area are set as determination areas in a second game. Therefore, the first game and the second game can be provided in a form such that they are related.

Abstract: The invention is directed to a gaming machine and method of providing a game. The game machine comprises a display and a controller. The display is configured to display a plurality of symbol positions displayed in a grid. The controller is configured to: initiate a game and define an initial result, the initial result including a symbol in each of the symbol positions within the grid; detect a trigger condition, the trigger condition being a collection of the same symbol within every position of the grid along a first axis; determine at least one adjacent axis from the first axis as a function of predetermined criteria; and copy the same symbol into at least one predetermined position along the adjacent axis.

Abstract: A gaming machine, a method of controlling a gaming machine, and a computer-readable recording medium storing a program wherein a first game and a second game are related to each other are provided. In a gaming machine, a first area and a second area sharing virtual reel strips are displayed, only the first area is set as a determination area in a first game, and both the first area and the second area are set as determination areas in a second game. Therefore, the first game and the second game can be provided in a form such that they are related.

Abstract: A gaming machine, a method of controlling a gaming machine, and a computer-readable recording medium storing a program wherein a first game and a second game are related to each other are provided. In a gaming machine, a first area and a second area sharing virtual reel strips are displayed, only the first area is set as a determination area in a first game, and both the first area and the second area are set as determination areas in a second game. Therefore, the first game and the second game can be provided in a form such that they are related.

Abstract: A gaming machine, a method of controlling a gaming machine, and a computer-readable recording medium storing a program wherein a first game and a second game are related to each other are provided. In a gaming machine, a first area and a second area sharing virtual reel strips are displayed, only the first area is set as a determination area in a first game, and both the first area and the second area are set as determination areas in a second game. Therefore, the first game and the second game can be provided in a form such that they are related.

Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.

Abstract: The invention is directed to a gaming machine and method of providing a game. The game machine comprises a display and a controller. The display is configured to display a plurality of symbol positions displayed in a grid, the grid defining a plurality of columns. The controller is configured to: initiate a game; determine at least one symbol associated with each of the plurality of symbol positions along at least one of the columns and display the symbols in the at least one column; evaluate the symbols displayed within the at least one column to determine a highest ranked symbol; replace all remaining symbols displayed within the at least one column with the highest ranked symbol; and insert the highest ranked symbol into the symbol positions of at least one other column within the grid.

Abstract: A gaming machine for providing a game to a player is described herein. The gaming machine displays a primary game including a plurality of reels, detects a triggering condition occurring with the primary game and responsively displays a secondary game. The secondary game includes a player character and an enemy character being displayed on an animated game field. The gaming machine displays a plurality of dice on the animated game field including a player die displayed with a player strength value and an enemy die displayed with an enemy strength value. The gaming machine displays an expandable image of the player strength value at a first size and increases the size of the expandable image to a larger second size over a predefined period of time.

Abstract: The invention is directed to a gaming machine and method of providing a game. The game machine comprises a display and a controller. The display is configured to display a plurality of symbol positions displayed in a grid, the grid defining a plurality of columns. The controller is configured to: initiate a game; determine at least one symbol associated with each of the plurality of symbol positions along at least one of the columns and display the symbols in the at least one column; evaluate the symbols displayed within the at least one column to determine a highest ranked symbol; replace all remaining symbols displayed within the at least one column with the highest ranked symbol; and insert the highest ranked symbol into the symbol positions of at least one other column within the grid.

Abstract: The invention is directed to a gaming machine and method of providing a game. The game machine comprises a display and a controller. The display is configured to display a plurality of symbol positions displayed in a grid, the grid defining a plurality of columns. The controller is configured to: initiate a game; determine at least one symbol associated with each of the plurality of symbol positions along at least one of the columns and display the symbols in the at least one column; evaluate the symbols displayed within the at least one column to determine a highest ranked symbol; replace all remaining symbols displayed within the at least one column with the highest ranked symbol; and insert the highest ranked symbol into the symbol positions of at least one other column within the grid.

Abstract: A gaming device for providing an award to a player is described herein. The gaming device displays a primary game including a plurality of reels and a plurality of symbols displayed with reels, generates an outcome of the primary game, and provides a primary award as a function of the outcome. The gaming device detects a triggering condition occurring with the primary game and responsively displays a secondary game including a game board having a plurality of paths and a plurality of position locations defined along each of the plurality of paths. The gaming device determines a current player position within the game board and responsively displays a player symbol at the current player position. The current player position is associated with one of the plurality of position locations and is indicative of a previous position location of the player symbol at a completion of a previous secondary game.

Abstract: A gaming machine for providing a game to a player is described herein. The gaming machine displays a primary game including a plurality of reels, detects a triggering condition occurring with the primary game and responsively displays a secondary game. The secondary game includes a player character and an enemy character being displayed on an animated game field. The gaming machine randomly selects an enemy strength value associated with the enemy character, randomly selects a player strength value associated with the player character, and determines an outcome of the secondary game including whether the player character defeats the enemy character as a function of the player strength value and the enemy strength value.

Abstract: A gaming machine for providing a game to a player is described herein. The gaming machine displays a primary game including a plurality of reels, detects a triggering condition occurring with the primary game and responsively displays a secondary game. The secondary game includes a player character and an enemy character being displayed on an animated game field. The gaming machine displays a plurality of dice on the animated game field including a player die displayed with a player strength value and an enemy die displayed with an enemy strength value. The gaming machine displays an expandable image of the player strength value at a first size and increases the size of the expandable image to a larger second size over a predefined period of time.

Abstract: A slot game is provided. A display device displays a plurality of reels. During the slot game the reels are spun and an outcome of the game is randomly determined. The outcome of the game is displayed on the display device in a grid comprised of a plurality of symbol positions in a predetermined arrangement. One of the symbols from a corresponding reel are displayed at each symbol position. The spinning reels are visible in the grid during play of the game. The controller awards the player an award as a function of the wager, the outcome of the game and a predetermined paytable. A first one of the reels contains a stack of adjacent, similar symbols. The stack of adjacent similar symbols are displayed with a first single graphic overlay.

Abstract: A gaming machine and method are provided which provide a plurality of games on a display device to a player. The outcome of the games are randomly selected and displayed on the display device. For each game: if the outcome is a winning outcome an award is awarded to the player as a function of the outcome, the wager made by the player, and a predetermined paytable and if a triggering condition in the outcome of each game, an other award is responsively awarded to the player if the triggering condition is detected in at least two of the plurality of games.