Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having opposing proximal and distal ends and defining a lumen that extends between the proximal and distal ends. One or more windows are defined in the cannula at or near the distal end, and one or more compliant deflection devices are arranged at or near the distal end and at least partially receivable within the one or more windows. Each compliant deflection device includes a radial biasing member that extends radially inward toward a centerline of the cannula.

Abstract: A food storage appliance is provided including a housing containing operative components of the food storage appliance. There is a first heat sealing element disposed on a lower portion of the housing configured to heat seal a first end of a section of food storage container material forming a food storage container unsealed at a second end. A vacuum chamber is disposed in an upper portion of the housing connected to a source of suction. A second heat sealing element is disposed in the upper portion of the housing adjacent to the vacuum chamber configured to heat seal the second end of the food storage container after being inserted into the vacuum chamber and being evacuated by suction from the suction source.

Abstract: One or more computing devices, systems, and/or methods for determining thresholds are provided. For example, first activity associated with a plurality of client devices may be detected. A first activity distribution associated with the plurality of client devices may be determined based upon the first activity. A plurality of peaks of the first activity distribution may be identified. A plurality of gradients associated with pairs of peaks of the plurality of peaks may be determined. A target peak of the plurality of peaks may be determined based upon the plurality of gradients. A threshold amount of activity associated with the first activity may be determined based upon the target peak. A first set of activity associated with a first client device may be detected. A fraudulence label associated with the first client device may be determined based upon the first set of activity and/or the threshold amount of activity.

Abstract: One or more computing devices, systems, and/or methods are provided. A request for content associated with a device and/or a set of request information associated with the request for content may be received. A content item may be transmitted to the device. A set of client information associated with the device may be received. The set of client information may be analyzed to determine a fraudulence label associated with the request for content. Fraud detection information generated based upon the set of request information, the set of client information and/or the fraudulence label may be stored in a fraud detection database. A second request for content associated with a second device and/or a second set of request information associated with the second request for content may be received. A second fraudulence label may be determined based upon the second set of request information and/or the fraud detection database.

Abstract: Described herein are Janus kinase (JAK) inhibitors and methods of utilizing JAK inhibitors in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: A gas analysis system includes spectroscopy assembly coupled to a vehicle. The spectroscopy assembly includes a plurality of emitters configured to emit a plurality of light beams toward a target surface. Each light beam of the plurality of light beams comprises a predetermined wavelength. The spectroscopy assembly includes a collection optic configured to receive a plurality of reflected light beams reflected from the target surface. Additionally, the spectroscopy assembly includes a detector configured to receive the plurality of reflected light beams from the collection optic and to detect a spectral intensity of the plurality of reflected light beams. Further, the spectroscopy assembly includes a controller configured to receive a light beam signal from the detector indicative of the spectral intensity of the plurality of reflected light beams. The controller is configured to detect a target fluid based on the light beam signal.

Abstract: An additive manufacturing system includes a laser device, a build plate, a first scanning device, and an alignment system. The laser device is configured to generate a laser beam. The build plate has a position relative to the laser device. The first scanning device is configured to selectively direct the laser beam across the build plate. The laser beam generates a melt pool on the build plate. The alignment system includes a fiducial marks projector configured to project a plurality of fiducial marks across the build plate. Each fiducial mark has a location on the build plate. The alignment system also includes an optical detector configured to detect the location of each of the fiducial marks on the build plate. The alignment system is configured to detect the position of the build plate relative to the laser device.

Abstract: Described herein are heterocyclic compounds, compositions, and methods for their use for the treatment of disease.

Abstract: A consolidating device for an additive manufacturing system is provided. The consolidating device includes at least one first energy beam generator, at least one second energy beam generator, at least one first lens, at least one second lens, and at least one reflective element. The first energy beam generator is configured to generate a first energy beam. The second energy beam generator is configured to generate a second energy beam. The first lens has a first entrance pupil and is positioned between the first energy beam generator and the layer of material. The second lens has a second entrance pupil and is positioned between the first lens and the layer of material. The first entrance pupil and the second entrance pupil substantially overlap. The reflective element is positioned between the first lens and the second lens, and is configured to reflect the second energy beam onto the layer of material.

Abstract: A smoke evacuation device includes one or more cooling mechanisms and an exhaust mechanism to reduce velocity and noise of filtered air exiting the smoke evacuation system. The cooling mechanism includes ventilation openings and/or a rotary mechanism disposed within the system to circulate air and cool by convective heat transfer. A pressure relief mechanism is also provided at the inlet or outlet of the system or the pump within the system. The pressure relief mechanism is configured to reduce pressures due to abnormal flows within the smoke evacuation system.

Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula coupled to the trocar housing at a proximal end to facilitate communication between the cannula and the working chamber. A tool stabilizing device is coupled to at least one of the trocar housing and the cannula and is actuatable to stabilize and center a surgical tool within the cannula.

Abstract: A fluid trap for minimizing the escape of contaminated fluids from the fluid trap when an orientation of the fluid trap changes during removal or transport includes a front cover, a rear cover coupled to the front cover, and an interior chamber defined by the front and rear covers. The front cover defines an inlet port extending a first distance into an interior chamber of the fluid trap. The rear cover defines an exhaust port extending a second distance away from the rear cover of the fluid trap and positioned above the inlet port when the fluid trap is in an upright position. The interior chamber has a maximum fluid volume defined as the lesser of a fluid reservoir volume, a front cover volume, and a rear cover volume.

Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having a proximal end and a distal end and defining a lumen that extends between the proximal and distal ends. The cannula is coupled to the trocar housing at the proximal end to facilitate communication between the lumen and the working chamber. A plurality of compliant deflection devices are provided at or near the distal end of the cannula, and each compliant deflection device includes a radial biasing member that extends radially inward toward a centerline of the cannula to center a surgical tool within the lumen and minimize unintended oscillation and vibration of the surgical tool.

Abstract: A filter includes (i) a filter body, (ii) a front cap associated with a first end of the filter body and coupled to and receiving smoke from a vacuum hose, (iii) a back cap associated with a second end of the filter body and having a filter exhaust sized and shaped to associate with and communicate suction from a smoke evacuation system, (iv) a compressed carbon reservoir disposed within the filter body between the front cap and the back cap, and (v) a flexible porous barrier disposed on at least a first side of the compressed carbon reservoir. The compressed carbon reservoir is under a compressive bias by the flexible porous barrier that transitions from a flexed state to a partially relaxed state in response to the compressed carbon reservoir reducing in volume.

Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having a proximal end and a distal end and defining a lumen that extends between the proximal and distal ends. The cannula is coupled to the trocar housing at the proximal end to facilitate communication between the lumen and the working chamber. A radial biasing device is arranged at or near the distal end of the cannula and includes an annular body coupled to the cannula and a compliant stabilizing member transitionable between a relaxed position and an extended position when acted upon by a surgical tool introduced into the lumen and passing through the compliant stabilizing member.

Abstract: A method and apparatus for determining a pressure in an annulus between an inner casing and an outer casing. An acoustic transducer is disposed within the casing at a selected depth within the inner casing and is configured to generate an acoustic pulse and receive a reflection of the acoustic pulse from the inner casing. A time of flight is measured of the acoustic pulse to the inner surface of the inner casing. An inner diameter of the inner casing is determined from the time of flight. The pressure in the annulus is determined from the inner diameter. A processor can be used to measure time and determine inner diameter and annulus pressure.

Abstract: An additive manufacturing system is configured to manufacture a component. The additive manufacturing system includes a build platform, a recoater, a monitoring camera, and a controller. The component is disposed on the build platform. The recoater includes a recoater blade configured to spread a powdered build material across the build platform and the component forming a powder bed. The monitoring camera is positioned to image the recoater blade. The monitoring camera is configured to acquire a plurality of images of the recoater blade. The controller is configured to receive the plurality of images from the monitoring camera. The controller is configured to detect defects in the powder bed based on the plurality of images received from the monitoring camera.

Abstract: Described herein are heterocyclic compounds, compositions, and methods for their use for the treatment of disease.

Abstract: A gas analysis system includes spectroscopy assembly coupled to a vehicle. The spectroscopy assembly includes a plurality of emitters configured to emit a plurality of light beams toward a target surface. Each light beam of the plurality of light beams comprises a predetermined wavelength. The spectroscopy assembly includes a collection optic configured to receive a plurality of reflected light beams reflected from the target surface. Additionally, the spectroscopy assembly includes a detector configured to receive the plurality of reflected light beams from the collection optic and to detect a spectral intensity of the plurality of reflected light beams. Further, the spectroscopy assembly includes a controller configured to receive a light beam signal from the detector indicative of the spectral intensity of the plurality of reflected light beams. The controller is configured to detect a target fluid based on the light beam signal.

Abstract: An imaging device for an additive manufacturing system is provided. The additive manufacturing system includes a material. The imaging device includes a high resolution imaging bar including at least one detector array, and an imaging element positioned between the at least one detector array and the material. The high resolution imaging bar is displaced from the material along a first direction and extends along a second direction. The high resolution imaging bar is configured to generate an image of a build layer within the material.