Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: wherein X, L, V, R1, R2, R3 and R4, are as defined herein.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: Methods of cementing include providing a geopolymer cement composition that includes a monophase amorphous hydraulic binder material (MAHBM), a metal silicate, an alkaline activator, and a carrier fluid, introducing the geopolymer cement composition into a subterranean formation, and allowing the geopolymer cement composition to set in the subterranean formation. The MAHBM includes silica or alumina core particulates coated with an amorphous calcium silicate hydrate.

Abstract: Systems, methods, and apparatuses of the present disclosure generally relate to dissolvable plugs for separating fluids in a wellbore. A dissolvable plug includes a first end comprising a first fluid barrier. The first fluid barrier includes a polymer film. The dissolvable plug also includes a second end opposite to the first end. The second end comprises a second fluid barrier. The second fluid barrier comprises a polymer film. The dissolvable plug includes a solid structure made of a sand and salt mixture.

Abstract: A method of cementing may include preparing a cement slurry by mixing at least water and a cement dry blend, wherein the cement dry blend comprises a cement and an activated pozzolan; and introducing the cement slurry into a wellbore penetrating a subterranean formation; and allowing the cement slurry to set to form a hardened mass.

Abstract: A method of cementing in a subterranean formation may include, activating an extended-life cement composition by mixing at least the extended-life cement composition with a liquid activated pozzolan additive comprising a carrier fluid and an activated pozzolan, wherein the extended-life cement composition comprises water, pumice, hydrated lime, and a set retarder; introducing the extended-life cement composition into a subterranean formation; and allowing the extended-life cement composition to set to form a hardened mass in the subterranean formation.

Abstract: A method of cementing may include: mixing at least a cement dry blend, water, and a liquid activated pozzolan additive to form a cement slurry, wherein the liquid activate pozzolan additive comprises a carrier fluid and an activated pozzolan; introducing the cement slurry into a wellbore penetrating a subterranean formation; and allowing the cement slurry to set.

Abstract: Disclosed herein are methods and compositions for cementing. An example method may comprise providing a cement composition. The cement composition may comprise a composite cementitious material comprising a micronized particulate solid and a monophase amorphous hydraulic binder. The micronized particulate solid may have a mean particle size of about 500 microns or less. The cement composition may further comprise water. The method may further comprise introducing the cement composition into a subterranean formation; and allowing the cement composition to set.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to and neutralize the activity of L1-CAM protein. The antibodies of the present technology are useful in methods for detecting and treating a L1-CAM-positive cancer in a subject in need thereof.

Abstract: Methods of cementing include providing a geopolymer cement composition that includes a monophase amorphous hydraulic binder material (MAHBM), a metal silicate, an alkaline activator, and a carrier fluid, introducing the geopolymer cement composition into a subterranean formation, and allowing the geopolymer cement composition to set in the subterranean formation. The MAHBM includes silica or alumina core particulates coated with an amorphous calcium silicate hydrate.

Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

Abstract: The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characterisitic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.

Abstract: Methods of cementing include providing a geopolymer cement composition that includes a monophase amorphous hydraulic binder material (MAHBM), a metal silicate, an alkaline activator, and a carrier fluid, introducing the geopolymer cement composition into a subterranean formation, and allowing the geopolymer cement composition to set in the subterranean formation. The MAHBM includes silica or alumina core particulates coated with an amorphous calcium silicate hydrate.

Abstract: Expansive cement compositions for use in subterranean wellbores that include a monophase amorphous hydraulic binder material (MAHBM). The MAHBM may include a plurality of particles having a silica core and an amorphous coating substantially surrounding the silica core. The coating may comprise, for example, a plurality of amorphous ?-dicalcium silicate hydrate nanoparticles or microparticles. The MAHBM may be used as an expansion agent in a cement composition or used as an expansive cement by itself.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to delta-like protein 3 (DLL3). The antibodies of the present technology are useful in methods for detecting and treating a DLL3-associated cancer in a subject in need thereof.

Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

Abstract: The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.

Abstract: Wellbore cement compositions can be managed based on material characteristics determined from a cement sample. For example, a cement sample can be retrieved from a wellbore. The cement sample can be analyzed using a plurality of sensors to generate a three-dimensional mapping of particles in the cement sample. The three-dimensional mapping can represent three-dimensional spatial relationships between the particles in the cement sample. The three-dimensional mapping can be compared to baseline three-dimensional mappings in a database. The comparison of the three-dimensional mappings can be used to identify at least one material characteristic of the cement sample. Based on the at least one material characteristic of the cement sample, a cement mixture can be prepared or information related to the cement mixture can be output.

Abstract: Intelligent illumination device are disclosed that use components in an LED light to perform one or more of a wide variety of desirable lighting functions for very low cost. The LEDs that produce light can be periodically turned off momentarily, for example, for a duration that the human eye cannot perceive, in order for the light to receive commands optically. The optically transmitted commands can be sent to the light, for example, using a remove control device. The illumination device can use the LEDs that are currently off to receive the data and then configure the light accordingly, or to measure light. Such light can be ambient light for a photosensor function, or light from other LEDs in the illumination device to adjust the color mix.