Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: A thin film and a method of making a thin film. The thin film comprises a patterned substrate, a smooth film of electric field tuned quantum dots solution positioned on the patterned substrate, and a thin layer of metal positioned on the thin film. The method begins by drop-casting a quantum dots solution onto a patterned substrate to create a thin film. While the quantum dots solution is drying, a linearly increasing electric filed is applied. The thin film is then placed in a deposition chamber and a thin layer of metal is deposited onto the thin film. Also included are a method of measuring the photoinduced charge transfer (PCT) rate in a quantum dot nanocomposite film and methods of forming a Shottky barrier on a transparent ITO electrode of a quantum dot film.

Abstract: The real-time cyber threat indicator verification mechanism technology (hereinafter “TIVM”) instantiates one or more virtual client emulators to access a source of a threat, in response to a received threat indicator, so as to evaluate validity and/or severity of the potential threat. In one embodiment, the TIVM may receive a cyber threat indicator having identifying information of a cyber threat source; instantiate, in response to the cyber threat indicator, a virtual client emulator; send a control message to cause the virtual client emulator to interact with the cyber threat source based on the identifying information; obtain a confidence indicator relating to the cyber threat indicator based on interaction between the virtual client emulator and the cyber threat source; and generate a cyber threat indicator confirmation report including the confidence indicator.

Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.

Abstract: In some embodiments, an apparatus includes a memory, storing processor-executable instructions, blacklist terms, and credential dump records, and a processor. The processor receives repository data from targeted remote repositories and stores the repository data as a potential credential dump in the memory when the repository data includes a credential dump attribute. The processor stores the potential credential dump as a probable credential dump when the potential credential dump does not include a blacklist term, in which case the processor also detects a format and delimiter of the probable credential dump. Based on the format and delimiter, pairs of usernames and associated passwords are identified and hashed. If a percentage of the hashes not associated with the credential dump records exceeds a predetermined threshold, the probable credential dump is deemed authentic.

Abstract: Disclosed is a method of spraying a surface with a set-delayed cement. The method comprises providing a set-delayed cement composition comprising water, pumice, hydrated lime, and a set retarder; spraying a surface with the set-delayed cement composition; and allowing the set-delayed cement composition to set on the surface.

Abstract: Disclosed herein are cement compositions and methods of using set-delayed cement compositions in subterranean formations. An embodiment includes a method of cementing in a subterranean formation comprising: providing a cement composition comprising water, pumice, hydrated lime, a set retarder, and a strength enhancer, wherein the strength enhancer comprises at least one material selected from the group consisting of cement kiln dust, slag, amorphous silica, a pozzolan, and any combination thereof; introducing the cement composition into the subterranean formation; and allowing the cement composition to set in the subterranean formation.

Abstract: In some embodiments, an apparatus includes a memory, storing processor-executable instructions, blacklist terms, and credential dump records, and a processor. The processor receives repository data from targeted remote repositories and stores the repository data as a potential credential dump in the memory when the repository data includes a credential dump attribute. The processor stores the potential credential dump as a probable credential dump when the potential credential dump does not include a blacklist term, in which case the processor also detects a format and delimiter of the probable credential dump. Based on the format and delimiter, pairs of usernames and associated passwords are identified and hashed. If a percentage of the hashes not associated with the credential dump records exceeds a predetermined threshold, the probable credential dump is deemed authentic.

Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. The methods generally comprise administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that is designed to be substantially active in the gastrointestinal (GI) tract to inhibit NHE-mediated antiport of sodium ions and hydrogen ions therein.

Abstract: There is provided a system and method for multiple rights based video. Source video assets may be analyzed to identify segments associated with a restricted scope of rights, and replacement assets associated with rights of different restrictions may be provided. When a request is received to serve a particular source video asset, a correspondingly customized video asset may be constructed by analyzing the rights available to the target of the request and the associated rights of the available replacement assets. Multiple parameters may be utilized in such analysis, and may include criteria such as territorial region, audience age, paid subscription level, and intended distribution channel. Since video can be optimized for different targets largely automatically, wider distribution of content may be possible under stricter budget and schedule constraints. Potential benefits may include increased revenue streams, market penetration, and brand recognition.

Abstract: Current approaches to managing security intelligence data often address both threat and malicious behavior at the individual computer level, tracked by the Internet Protocol (IP) address. For example, important facts, observed behavior, and other indications that are tracked by security organizations are only tracked with respect to individual IP addresses. Bilateral network inheritance generally refers to inheriting a variety of attributes from parents to children and from children to parents in a computer network hierarchy. The computer network hierarchy may comprise various entities such as, for example, top level entities, autonomous systems, address ranges, and individual IP addresses.

Abstract: Disclosed is a method of cementing. The method comprises providing a set-delayed cement composition comprising water, pumice, hydrated lime, a set retarder, and a micro-electrical-mechanical system; and allowing the set-delayed cement composition to set.

Abstract: Disclosed is a method of spraying a surface with a set-delayed cement. The method comprises providing a set-delayed cement composition comprising water, pumice, hydrated lime, and a set retarder; spraying a surface with the set-delayed cement composition; and allowing the set-delayed cement composition to set on the surface.

Abstract: In some embodiments, an apparatus includes a memory, storing processor-executable instructions, blacklist terms, and credential dump records, and a processor. The processor receives repository data from targeted remote repositories and stores the repository data as a potential credential dump in the memory when the repository data includes a credential dump attribute. The processor stores the potential credential dump as a probable credential dump when the potential credential dump does not include a blacklist term, in which case the processor also detects a format and delimiter of the probable credential dump. Based on the format and delimiter, pairs of usernames and associated passwords are identified and hashed. If a percentage of the hashes not associated with the credential dump records exceeds a predetermined threshold, the probable credential dump is deemed authentic.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

Abstract: The real-time cyber threat indicator verification mechanism technology (hereinafter “TIVM”) instantiates one or more virtual client emulators to access a source of a threat, in response to a received threat indicator, so as to evaluate validity and/or severity of the potential threat. In one embodiment, the TIVM may receive a cyber threat indicator having identifying information of a cyber threat source; instantiate, in response to the cyber threat indicator, a virtual client emulator; send a control message to cause the virtual client emulator to interact with the cyber threat source based on the identifying information; obtain a confidence indicator relating to the cyber threat indicator based on interaction between the virtual client emulator and the cyber threat source; and generate a cyber threat indicator confirmation report including the confidence indicator.

Abstract: Embodiments relate to cementing operations and, in certain embodiments, to passivated cement accelerators and methods of using passivated cement accelerators in subterranean formations. An embodiment may comprise a method of cementing comprising: providing a cement composition comprising cement, water, and a passivated cement accelerator; and allowing the cement composition to set.

Abstract: Current approaches to managing security intelligence data often address both threat and malicious behavior at the individual computer level, tracked by the Internet Protocol (IP) address. For example, important facts, observed behavior, and other indications that are tracked by security organizations are only tracked with respect to individual IP addresses. Bilateral network inheritance generally refers to inheriting a variety of attributes from parents to children and from children to parents in a computer network hierarchy. The computer network hierarchy may comprise various entities such as, for example, top level entities, autonomous systems, address ranges, and individual IP addresses.

Abstract: Described herein are Tz/TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Abstract: An illumination device and methods are provided herein for avoiding over-current and over-power conditions in one or more power converters included within the illumination device. The illumination device may include at least a plurality of light emitting diode (LED) chains, a driver circuit, at least one power converter, and a control circuit. In some embodiments, the control circuit may be generally configured for determining a maximum safe current level and/or a maximum safe power level attributed to the power converter(s) at a present operating temperature, and for adjusting respective drive currents supplied to the plurality of LED chains by the driver circuit, so as not to exceed the maximum safe current level or the maximum safe power level at the present operating temperature. In some embodiments, a temperature sensor may be included within the illumination device for measuring the operating temperature presently associated with the power converter(s).