Abstract: A method for providing biofeedback to a user may include receiving a first signal associated with one or more biometric properties of a user, and determining a baseline cognitive state of the user based on the first signal. The method may include iteratively detecting an instant cognitive state of the user, and receiving, from the detecting step, a second signal associated with the one or more biometric properties. The method may include determining whether the second signal corresponds to threshold(s). Responsive to such determination, the method may include initiating first feedback action(s). Responsive to initiating the first feedback action(s), the method may include determining whether the instant cognitive state of the user is between the threshold(s) and the baseline cognitive state, and if not, initiating second feedback action(s).

Abstract: Systems and methods for aggregating data. The system is configured to receive metadata from an interactive graphical user interface (GUI) of a user device, aggregate field values from the data stored on one or more databases based on the received metadata and generate filter instructions based on the received metadata. The system is further configured to transmit the aggregated field values and the filter instructions to the user device, receive a user-customized filter set and subscription request for a synthetic symbol associated with the user-customized filter set from the user device, and create the synthetic symbol responsive to the subscription request. Moreover, the system aggregates one or more data values from the data stored on the databases associated with the created synthetic symbol and generates instructions to display the data values on the interactive GUI in accordance with the user-customized filter set associated with the created synthetic symbol.

Abstract: A method for processing requests to consolidate loans includes receiving, from one or more third party electronic computing devices, information regarding outstanding loans for a user that are issued by one or more third party lenders. The information is sent to a user electronic computing device. A selection is received of loans the user wishes to refinance or consolidate. A benefits analysis is performed for the loans. Based on the benefits analysis, a determination is made of whether any of the outstanding loans can be consolidated, and whether any of the loans are excluded from being consolidated. Consolidated loan information is sent to the user electronic computing device regarding a consolidated loan for any of the loans that can be consolidated. Exclusion information is sent to the user electronic computing device regarding any of the loans that are excluded from being consolidated.

Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).

Abstract: A system and method for managing a parking area of a rental complex is provided. Generally, a user may use the user interface of the system to input data pertaining to individual units of a rental complex, wherein each individual unit is associated with at least one parking space of a parking area. The parking space may have a specific location within a parking area or generally refer to one parking space of a plurality of parking spaces within a parking area. Preauthorization rules of the system dictate the maximum number of parking spaces a user of the system may be allocated at a given time. Users may manipulate user interfaces of the system to generate parking passes. In some embodiments, scanning devices may be used to help monitor parking areas by scanning parking passes generated by the system.

Abstract: A system may include a substrate in contact with a user. The substrate may include first detector(s) capable of detecting optical biometric properties of the user, and second detector(s) capable of detecting non-optical biometric properties of the user. The system may include a first and a second electronics module communicatively coupled to the substrate. Each of the two electronics modules may include a processor, a memory device, and instructions stored on the memory device that, when executed, direct the processor to perform step(s). These step(s) may include receiving a signal from the first detector(s) or second detector(s), processing the signal based on predefined algorithm(s), and determining, based on the processed signal, whether the user requires one or more feedback actions.

Abstract: Implementations of semantic parsing using pre-trained language models are provided. One aspect includes a computing system for semantic parsing of natural language.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: This invention relates to a parachute sea anchor system deployable from a payload tube. There is provided a parachute sea anchor system suitable for launch from a vessel comprising at least one payload tube, said payload tube, comprising a payload canister, which comprises a parachute sea anchor, wherein said parachute sea anchor comprises a buoy tethered thereto, wherein said payload canister is attached to said vessel.

Abstract: The disclosure relates to stable topical pharmaceutical compositions of SHR0302 (also known as ARQ-250). In certain embodiments, pharmaceutical compositions of SHR0302 having a pH of less than about 4.6 have improved stability and do not exhibit crystal formation of the API. In certain embodiments, pharmaceutical compositions of SHR0302 comprising about 20% to about 30% dimethyl sulfoxide (DMSO) have improved stability and do not exhibit crystal formation of the API. The improved formulations of SHR0302 can exhibit acceptable commercial product shelf life and do not exhibit loss of potency of the API after prolonged storage.

Abstract: The disclosure features modified regulatory T (TREG) cells having increased lineage stability, decreased activation of T cells (e.g., conventional T (TCONV) cells), and/or increased resistance to immune rejection, and methods of producing and using such cells, for example, in the treatment of graft versus host disease (GVHD).

Abstract: Apparatuses and methods for data traffic management in multi-source content delivery are described. The apparatus includes a downloader and a controller. The downloader is coupled to servers via communication links. The controller is configured to determine initial download requests for the servers based on predetermined information about a quality of the links. The controller is also configured to send the initial download requests to the servers with the downloader. The controller is further configured to update the information about the quality of the communication links after the downloader receives data associated with a data file from the servers via the communication links. The controller is also configured to determine subsequent download requests for the servers based on the updated information about the quality of the communication links. The controller of further configured to send the subsequent download requests to the servers via the downloader.

Abstract: A seat system with a seat back element including a vertical support disposed in a seat back interior region, and one or more first connector portions attached to the vertical support and aligned in a first direction, and a seat back panel having one or more second connector portions attached to an interior surface and configured to connect to the one or more first connector portions. The seat back panel has a first sidewall disposed at a first side and further has a second sidewall disposed on at a second side opposite the first side. The seat back panel has an upper wall portion forming a contiguous first surface with the first sidewall and second sidewall. The second connector portions connect to the first connector portions and attach the seat back panel to the seat back element.

Abstract: The disclosure provides probes comprising dipyrromethane-BF2 derivatives which exhibits different fluorescent spectral properties when conjugated to the amnio acids, compositions and kits comprising same. The disclosure also provides methods for detecting/identifying amino acids and sequencing polypeptide molecules by conjugating a dipyrromethane-BF2 derivative which exhibits different fluorescent spectral properties when conjugated to the amnio acids.

Abstract: Systems and methods for generating a data aggregator interactive graphical user interface. An interactive graphical user interface (GUI) includes a selectable symbol region, a query region and a data results region. The selectable symbol region displays predefined symbols. The query region displays user input fields for generating queries. The system receives user input associated with the user input fields of the query region to form a filter set. The data results region is automatically updated responsive to the user input, to display one or more data values from among one or more databases associated with the filter set. The system receives a subscription request to save the filter set as a user-customized query. A custom symbol is created responsive to the subscription request that is associated with the filter set. The selectable symbol region is updated to display the custom symbol together with the predefined symbols.

Abstract: Systems and methods for aggregating data. The system is configured to receive metadata from an interactive graphical user interface (GUI) of a user device, aggregate field values from the data stored on one or more databases based on the received metadata and generate filter instructions based on the received metadata. The system is further configured to transmit the aggregated field values and the filter instructions to the user device, receive a user-customized filter set and subscription request for a synthetic symbol associated with the user-customized filter set from the user device, and create the synthetic symbol responsive to the subscription request. Moreover, the system aggregates one or more data values from the data stored on the databases associated with the created synthetic symbol and generates instructions to display the data values on the interactive GUI in accordance with the user-customized filter set associated with the created synthetic symbol.

Abstract: A vehicle ECU receives an ECU update package from a remote source. The ECU verifies a first timestamp included with the ECU update package postdates a second timestamp stored onboard the vehicle in conjunction with a last-successful update of the ECU and obtains a unique vehicle identifier from the vehicle bus. The ECU obtains secure configuration data for the ECU included in a payload of the update package and calculates a first hash value using at least the unique vehicle identifier and the secure configuration data. Also, the ECU validates the update package based on comparison of the first hash value matching a second hash value included in the update package and, responsive to the first timestamp post-dating the second timestamp and validation of the update package, modifies the ECU through use of the secure configuration data.

Abstract: The present disclosure relates to managing services by a managed service provider (MSP) in a cloud based infrastructure. A control plane of the MSP is established in a first tenancy, and a first access plane of the MSP is established in a second tenancy of a cloud environment. The control plane is configured to manage a plurality of services offered by the MSP to a first host machine included in the second tenancy. A first request is transmitted from the control plane to the first access plane, where the first request is forwarded by the first access plane to the first host machine, and corresponds to a service utilized by the first host machine and managed by the control plane of the MSP. In response to the first request being validated, a first state of the first host machine is modified in the second tenancy based on the first request.