Patents by Inventor Jason O. Fiering
Jason O. Fiering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9046192Abstract: A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.Type: GrantFiled: January 31, 2008Date of Patent: June 2, 2015Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Mark J. Mescher, Jason O. Fiering, Erin E. Swan
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Publication number: 20150126411Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.Type: ApplicationFiled: November 6, 2014Publication date: May 7, 2015Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, JR., Mitchell Hansberry, Stephen Bellio
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Patent number: 9006149Abstract: A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.Type: GrantFiled: January 14, 2010Date of Patent: April 14, 2015Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr.
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Publication number: 20150070123Abstract: A method of forming a planar, low loss electrical component such as an inductor or transmission line is provided. A channel can be formed on a top surface of a substrate. A threading plate can be positioned on an upper surface of the channel. A wire or fiber can be introduced through the substrate, the channel, and the threading plate. The wire or fiber can then be guided into the channel using the threading plate. The substrate and the threading plate can then be removed.Type: ApplicationFiled: September 10, 2014Publication date: March 12, 2015Inventors: Amy Duwel, Joshua Nation, Jason O. Fiering, Doug White
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Publication number: 20150017737Abstract: Devices and methods are disclosed herein for separating a supernate from a suspension. The apparatus consists of a sample zone, a controllable gate, and an analysis zone. The sample zone holds the suspension. The analysis zone passively transports a supernate formed from the suspension by capillary transport. A controllable gate prevents the suspension in the sample zone from flowing into the analysis zone. The controllable gate can be triggered after the supernate has separated from the suspension to allow the supernate to flow into the analysis zone.Type: ApplicationFiled: September 29, 2014Publication date: January 15, 2015Inventor: Jason O. Fiering
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Patent number: 8900532Abstract: Devices and methods are disclosed herein for separating a supernate from a suspension. The apparatus consists of a sample zone, a controllable gate, and an analysis zone. The sample zone holds the suspension. The analysis zone passively transports a supernate formed from the suspension by capillary transport. A controllable gate prevents the suspension in the sample zone from flowing into the analysis zone. The controllable gate can be triggered after the supernate has separated from the suspension to allow the supernate to flow into the analysis zone.Type: GrantFiled: November 16, 2012Date of Patent: December 2, 2014Assignee: The Charles Stark Draper Laboratory, Inc.Inventor: Jason O. Fiering
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Patent number: 8876795Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: GrantFiled: February 2, 2012Date of Patent: November 4, 2014Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear InfirmaryInventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
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Publication number: 20140273276Abstract: Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicants: Northeastern University, The Charles Stark Draper Laboratory, Inc.Inventors: Jason O. Fiering, Dale Larson, Gregory Kowalski, Amy Taylor, Wajeeh M. Saadi, Mehmet Sen
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Publication number: 20140209542Abstract: Systems, methods, and compositions for removing organophosphate toxins from blood are disclosed herein. The compositions include a lipid-based capture particle that displays BChE that binds to the toxin. The methods include acoustically separating toxins bound to lipid-based capture particles from blood factors of whole blood.Type: ApplicationFiled: January 30, 2014Publication date: July 31, 2014Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Tammy Spain, Jason O. Fiering, Leila Albers
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Publication number: 20140140891Abstract: Devices and methods are disclosed herein for separating a supernate from a suspension. The apparatus consists of a sample zone, a controllable gate, and an analysis zone. The sample zone holds the suspension. The analysis zone passively transports a supernate formed from the suspension by capillary transport. A controllable gate prevents the suspension in the transport zone from flowing into the analysis zone. The controllable gate can be triggered after the supernate has separated from the suspension to allow the supernate to flow into the analysis zone.Type: ApplicationFiled: November 16, 2012Publication date: May 22, 2014Applicant: The Charles Draper Stark Laboratory, Inc.Inventor: Jason O. Fiering
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Patent number: 8679313Abstract: A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules.Type: GrantFiled: January 19, 2010Date of Patent: March 25, 2014Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Jason O. Fiering, Mark Keegan
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Publication number: 20130053823Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: ApplicationFiled: February 2, 2012Publication date: February 28, 2013Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
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Publication number: 20130048565Abstract: Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Inventors: Jason O. FIERING, Shivshankar Sundaram
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Patent number: 8292083Abstract: A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.Type: GrantFiled: April 18, 2008Date of Patent: October 23, 2012Assignees: The Charles Stark Draper Laboratory, Inc., Children's Medical Center CorporationInventors: Mathew Varghese, Jason O. Fiering, Donald E. Ingber, Nan Xia, Mark J. Mescher, Jeffrey T. Borenstein, Chong Wing Yung
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Publication number: 20120264224Abstract: Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.Type: ApplicationFiled: January 13, 2012Publication date: October 18, 2012Applicants: Northeastern University, The Charles Stark Draper Laboratory, Inc.Inventors: Jason O. Fiering, Dale Larson, Gregory Kowalski, Mehmet Sen
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Publication number: 20120149021Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel.Type: ApplicationFiled: January 15, 2010Publication date: June 14, 2012Applicants: The Charles Stark Draper Laboratory, Inc., Children's Medical Center CorporationInventors: Chong Wing Yung, Donald E. Ingber, Jason O. Fiering, Mathew Varghese
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Publication number: 20120068801Abstract: In various embodiments, an inductance of an inductor is tuned by adjusting a position of a conductor and/or a magnetic material with respect to a conducting wire of the inductor, thereby changing the electro-magnetic characteristics of the conducting wire. The conductor and/or magnetic material can be disposed in a microfluidic channel and can be moved within the microfluidic channel using a suitable actuator mechanism.Type: ApplicationFiled: October 4, 2011Publication date: March 22, 2012Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Amy E. Duwel, Jason O. Fiering, Douglas W. White, Brian R. Smith
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Publication number: 20120007778Abstract: In various embodiments, an actuating mechanism is employed to displace a conductor disposed within a fluidic channel, thereby reconfiguring an electronic component.Type: ApplicationFiled: July 8, 2010Publication date: January 12, 2012Inventors: Amy E. Duwel, Jason O. Fiering, Douglas W. White, Mark J. Mescher, Joseph M. Bauer, John R. Lachapelle, Bryan McLaughlin, Frans Spaepen
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Publication number: 20110295194Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.Type: ApplicationFiled: January 6, 2011Publication date: December 1, 2011Inventors: Jason O. Fiering, Mark J. Mescher, Sharon G. Kujawa, Michael J. McKenna, William F. Sewell
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Patent number: 7867193Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.Type: GrantFiled: January 28, 2005Date of Patent: January 11, 2011Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear InfirmaryInventors: Michael J. McKenna, Jason O. Fiering, Mark J. Mescher, Sharon G. Kujawa, William F. Sewell, Anthony A. Mikulec