Patents by Inventor Jason P. Schrum

Jason P. Schrum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
    Publication number: 20170028085
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Inventors: Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan WHORISKEY, Kristy M. Wood, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD, Ron WEISS
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
    Publication number: 20160375134
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: January 4, 2016
    Publication date: December 29, 2016
    Inventors: Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan Whoriskey, Kristy M. WOOD, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD
  • Modified polynucleotides for the production of nuclear proteins
    Patent number: 9504734
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: November 29, 2016
    Assignee: ModernaTX, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild, Ron Weiss
  • Engineered nucleic acids and methods of use thereof
    Patent number: 9464124
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 11, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS
    Publication number: 20160289674
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: June 6, 2016
    Publication date: October 6, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20160271272
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent viral infection, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: June 6, 2016
    Publication date: September 22, 2016
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Jason P. Schrum, Alexander Aristarkhov
  • Engineered nucleic acids and methods of use thereof
    Patent number: 9447164
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 20, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan, Kenechi Ejebe
  • MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
    Publication number: 20160264975
    Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.
    Type: Application
    Filed: April 29, 2016
    Publication date: September 15, 2016
    Inventors: Jason P. Schrum, Suhaib Siddiqi, Kenechi Ejebe
  • Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
    Patent number: 9428535
    Abstract: The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: August 30, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Antonin de Fougerolles, Atanu Roy, Jason P. Schrum, Suhaib Siddiqi, Paul Hatala, Stephane Bancel
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE
    Publication number: 20160199513
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: March 4, 2016
    Publication date: July 14, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
    Publication number: 20160193299
    Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
    Type: Application
    Filed: March 22, 2016
    Publication date: July 7, 2016
    Inventors: Antonin de Fougerolles, Kristy M. Wood, Sayda M. Elbashir, Noubar B. Afeyan, Pedro Valencia, Jason P. Schrum
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS
    Publication number: 20160158385
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES
    Publication number: 20160152678
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS
    Publication number: 20160151516
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: November 13, 2015
    Publication date: June 2, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Jeff Lynn Ellsworth, Kenechi Ejebe, Justin Guild, Matthias John, Paul Hatala, Atanu Roy, Jason P. Schrum, Susan Whoriskey, Kristy M. Wood
  • Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
    Patent number: 9334328
    Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: May 10, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Suhaib Siddiqi, Kenechi Ejebe
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
    Publication number: 20160114011
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 28, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild, Ron Weiss
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE
    Publication number: 20160075733
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: October 8, 2015
    Publication date: March 17, 2016
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • Modified polynucleotides for the production of proteins
    Patent number: 9254311
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Grant
    Filed: March 9, 2013
    Date of Patent: February 9, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
  • ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
    Publication number: 20160024171
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: October 8, 2015
    Publication date: January 28, 2016
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan, Kenechi Ejebe
  • IN VIVO PRODUCTION OF PROTEINS
    Publication number: 20150376648
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
    Type: Application
    Filed: August 12, 2015
    Publication date: December 31, 2015
    Inventors: Stephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild