Patents by Inventor Jason Witherington

Jason Witherington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease inhibitors
    Patent number: 6566373
    Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: May 20, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Andrew D Gribble, Ashley Edward Fenwick, Robert W Marquis, Daniel F Veber, Jason Witherington
  • Protease inhibitors
    Publication number: 20020082426
    Abstract: 1
    Type: Application
    Filed: February 27, 2002
    Publication date: June 27, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Ashley E. Fenwick, Andrew D. Gribble, Robert W. Marquis, Jason Witherington
  • Protease inhibitors
    Publication number: 20020013360
    Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
    Type: Application
    Filed: July 30, 2001
    Publication date: January 31, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Andrew D. Gribble, Ashley Edward Fenwick, Robert W. Marquis, Daniel F. Veber, Jason Witherington
  • Rearrangement of epoxides
    Patent number: 5750805
    Abstract: Epoxides containing hydroxy groups are rearranged enantioselectively using a chiral base to give allyl alcohols in high enantiomeric excess, e.g. ##STR1## If R.sup.3 .noteq.H, the reaction also has the effect of generating a chiral tetrasubstituted carbon atom.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: May 12, 1998
    Assignee: The University of Reading
    Inventors: David Michael Hodgson, Jason Witherington
  • Preparation process for beta-alkoxy acrylic acid
    Patent number: 5744635
    Abstract: A method for prerparing compounds of formula (I), wherein R is an optionally substituted alkenyl or alkynyl radical having up to 8 carbon atoms, or an optionally substituted mono- or polycyclic aryl or heteroaryl radical, and R.sub.1 and R.sub.2 are an alkyl radical having up to 4 carbon atoms. According to the method, a compound of the formula (II), wherein X is a halogen atom, is exposed to an organometallic compound of the formula (III): RZ, wherein R has the same meaning as before and Z is a metal or metal derivative. Alternatively, a compound of formula (II'), wherein Z' is a metal or metal derivative, is exposed to a compound of the formula (III'): RX', wherein X' is a nucleophilic reaction leaving group.
    Type: Grant
    Filed: October 3, 1995
    Date of Patent: April 28, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean-Louis Brayer, David Michael Hodgson, Ian Christopher Richards, Jason Witherington