Abstract: The invention generally relates to dosage regimes of anti-Cluster of Differentiation 73 (CD73) antibodies and/or anti-ectoenzyme ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) antibodies, used in methods of treatment of cancer in a subject, as well as dosage regimes of anti-CD73 antibodies for use in treating cancer. The invention further generally relates to dosage regimes of combinations of agents, such as combinations comprising anti-CD73 antibodies and/or anti-ENTPD2 antibodies and at least one or more of a PD-1 inhibitor, and an adenosine A2AR antagonist.

Abstract: Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

Abstract: Some embodiments of a manifold pad may be configured to distribute reduced pressure relative to a tissue site and to provide instillation to the tissue site. In some embodiments, the manifold pad may comprise open-cell foam and at least one skinned channel extending through the open-cell foam. The at least one skinned channel may be configured so that the skin is substantially impermeable to liquid, preventing liquid within the channel from seeping into the open-cell foam. In some embodiments, this may allow for two isolated pathways for fluid movement through the manifold pad. Some dressing embodiments may utilize such a manifold pad in conjunction with a treatment device. Other apparatus, dressings, systems, and methods are disclosed.

Abstract: Various aspects of techniques, systems, and use cases include provide instructions for calibrating or object identification in a human-robot interactive environment. A technique may include displaying a back illumination image having at least two distinct sections, capturing a scene including the first back illumination image and an object obstructing a portion of one of the at least two distinct sections of the first back illumination image, and identifying, using an orientation of the display screen relative to the camera (e.g., obtained via calibration), location information of the object relative to a robotic device based on the first scene. The technique may include outputting the location information.

Abstract: The technology described in this document can be embodied in a computer-implemented method that includes receiving, at a processing system, a first signal including an output of a speaker device and an additional audio signal. The method also includes determining, by the processing system, based at least in part on a model trained to identify the output of the speaker device, that the additional audio signal corresponds to an utterance of a user. The method further includes initiating a reduction in an audio output level of the speaker device based on determining that the additional audio signal corresponds to the utterance of the user.

Abstract: The arrangement includes a latch pivotally mounted to cooperate with a catch, a lock member including a locking ratchet arranged to cooperate with the latch between initial and intermediate locking configurations of the latch, following at least one movement control action of the ratchet by an actuator, an ejector arranged to drive, with the ejection thereof, the pivoting of the latch and the lifting of the hood, the latch and the ejector forming an ejection member of the striker. During the movement of the ratchet from the initial configuration to the final configuration, the lock member is arranged to pivot the ejection member in an ejection direction against the resultant torque of the weight of the hood exerted on the ejector via the striker in order to enable the lifting of the hood.

Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.

Abstract: A laser eye surgery system focuses light along a beam path to a focal point having a location within a lens of the eye. The refractive index of the lens is determined in response to the location. The lens comprises a surface adjacent a second material having a second refractive index. The beam path extends a distance from the surface to the focal point. The index is determined in response to the distances from the surface to the targeted focal point and from the surface to the actual focal point, which corresponds to a location of a peak intensity of an optical interference signal of the focused light within the lens. The determined refractive index is mapped to a region in the lens, and may be used to generate a gradient index profile of the lens to more accurately place laser beam pulses for incisions.

Abstract: Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

Abstract: Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.

Abstract: Methods and systems for planning and forming incisions in a cornea, lens capsule, and/or crystalline lens nucleus are disclosed. A method includes measuring spatial dispositions, relative to a laser surgery system, of at least portions of the corneal anterior and posterior surfaces. A spatial disposition of an incision of the cornea is generated based at least in part on the measured corneal anterior and posterior spatial dispositions and at least one corneal incision parameter. A composite image is displayed that includes an image representative of the measured corneal anterior and posterior surfaces and an image representing the corneal incision.

Abstract: Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.

Abstract: Methods and systems for planning and forming incisions in a cornea, lens capsule, and/or crystalline lens nucleus are disclosed. A method includes measuring spatial dispositions, relative to a laser surgery system, of at least portions of the corneal anterior and posterior surfaces. A spatial disposition of an incision of the cornea is generated based at least in part on the measured corneal anterior and posterior spatial dispositions and at least one corneal incision parameter. A composite image is displayed that includes an image representative of the measured corneal anterior and posterior surfaces and an image representing the corneal incision.

Abstract: In a cataract procedure, a new geometry of a lens segmentation pattern reduces the required phacoemulsification energy to remove the lens. The lens segmentation process employs a three-dimensional spiral lens segmentation pattern that resembles a spiral staircase or a spiral ramp, to incise a vertical cylindrical volume of the lens into a three-dimensional spiral that can be more easily removed. The segmentation patter is formed by scanning the laser focal spot in a layer by layer manner, each layer including a closed curve corresponding to the outer boundary of the segmentation volume, and a filled area inside the closed curve forming a horizontal step of the spiral staircase. The horizontal steps of vertically adjacent layers are offset by an offset angle, creating the spiral lens segmentation pattern that form a spiral volume.

Abstract: Some embodiments of a manifold pad may be configured to distribute reduced pressure relative to a tissue site and to provide a lateral contractive force relative to the tissue site. In some embodiments, the manifold pad may comprise a foam having a cell-structure forming ovoidal or ellipsoidal pores. In some embodiments, the manifold pad may be configured to preferentially contract radially or laterally upon application of negative pressure. For example, the manifold pad may be configured to be more resistant to collapse of the thickness of the manifold pad than to collapse radially or laterally. Other apparatus, dressings, systems, and methods are disclosed.

Abstract: Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.

Abstract: Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.

Abstract: In a laser cataract procedure that also corrects for astigmatism, an iris registration method compares an iris image of a patient's eye taken when the eye is not docked to a patient interface device with an iris image of the same eye that is docked to the patient interface, to calculate a rotation angle between the two images. The astigmatism axis of the eye is measured when the eye is not docked, and the measured axis is rotated by the calculated rotation angle to obtain a rotated astigmatism axis relative to the iris image of the docked eye. The laser cataract procedure is performed based on the rotated astigmatism axis. The rotation angle is calculated by optimizing a transformation that transforms the undocked iris image to match the docked iris image, where the transformation includes a dilation factor that accounts for different pupil dilation of the two iris images.

Abstract: The opening control device includes a fixed support configured to be mounted on the door leaf, a handle movably mounted on the support, a mechanism for electrical and mechanical activation of an unlocking of a latch of the motor vehicle door leaf respectively for electrically and mechanically actuating the unlocking of the latch, the mechanism being mechanically coupled with the handle of the vehicle such that the application of a predefined pulling force on the handle causes the electrical or mechanical activation of the unlocking of the latch. The activation mechanism includes a first lever for electrical activation of the latch and a second lever for mechanical activation of the latch movably mounted relative to each other.

Abstract: A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.