Abstract: The present disclosure provides a fluid control device for use with a negative pressure wound therapy system including a pump having an inlet and an outlet. The fluid control device includes a first valve, a second valve, and a canister assembly. The canister assembly includes a first canister including a first chamber and a first diaphragm dividing the first chamber into a first air chamber and a first exudate chamber. The canister assembly further includes a second canister including a second chamber and a second diaphragm dividing the second chamber into a second air chamber and a second exudate chamber. The first valve is configured to selectively fluidly communicate the inlet with one of the first air chamber and the second air chamber. The second valve is configured to selectively fluidly communicate the outlet with the other of the first air chamber and the second air chamber.

Abstract: A dressing for an open abdominal wound is disclosed. The dressing includes a first manifold configured to be disposed within the open abdominal wound. The dressing further includes a traction film attached at least partially to the first manifold and configured to be disposed within the open abdominal wound. The traction film includes a plurality of microstructures extending away from the first manifold and a plurality of through openings. The plurality of microstructures is configured to engage a bottom surface of an abdominal wall around the open abdominal wound. The first manifold is configured to receive a negative pressure from a negative pressure source via the plurality of through openings of the traction film.

Abstract: Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

Abstract: A system and method for box dimensioning are disclosed. The system comprises a scanner to capture images of at least one object with at least one image capturing device and create one or more coloured map images for obtaining pixel information. Further, one or more sensors are configured to determine depth and distance information of each pixel of one or more coloured map images. Further, the system comprises at least one system processor to determine a plurality of pixel coordinates of each corner of a plurality of corners of at least one object based at least on distance information, determine a plurality of corner points of each corner based at least on plurality of pixel coordinates, map each corner point of plurality of corner points to a respective predefined distance, and determine a plurality of dimensions of at least one object based at least on mapping and determined depth information.

Abstract: Apparatus, systems, and methods for purging exudate from a fluid container suitable for use with negative pressure therapy. A canister assembly configured to purge exudate can include a primary container, a first one-way valve, and a second one-way valve. The primary container can include an internal volume, a pressure inlet port, an exudate inlet port, and an exudate outlet port each in fluid communication with the internal volume. The first one-way valve can be in fluid communication with the exudate inlet port and the internal volume and configured to permit fluid flow into the internal volume and to restrict fluid flow out of the internal volume. The second one-way valve can be in fluid communication with the exudate outlet port and the internal volume and configured to permit fluid flow out of the internal volume and to restrict fluid flow into the internal volume.

Abstract: The present disclosure provides methods include receiving an I-O from host system, determining whether an overwrite count of data of the I-O placed by the host system in a placement handle is different from an average overwrite count of data in the placement handle upon receiving the I-O, grouping one or more pages corresponding to the data of the I-O in the placement handle to another placement handle that matches the overwrite count of the data of the I-O based on the determination of the overwrite count of the data of the I-O in the placement handle being different from the average overwrite count of data in the placement handle of the storage device during an internal operation, and. updating a log page to record the grouping of the one or more pages.

Abstract: Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.

Abstract: Methods and systems for planning and forming incisions in a cornea, lens capsule, and/or crystalline lens nucleus are disclosed. A method includes measuring spatial dispositions, relative to a laser surgery system, of at least portions of the corneal anterior and posterior surfaces. A spatial disposition of an incision of the cornea is generated based at least in part on the measured corneal anterior and posterior spatial dispositions and at least one corneal incision parameter. A composite image is displayed that includes an image representative of the measured corneal anterior and posterior surfaces and an image representing the corneal incision.

Abstract: A dressing, system, and method for treating a tissue site is described. The dressing includes a tissue interface having a fluid flow path and an encapsulating film at least partially encapsulating the tissue interface. An indicator is disposed adjacent to the tissue interface proximate to at least one location along the fluid flow path.

Abstract: A wound therapy system includes a dressing sealable over a wound and defining a wound space between the dressing and the wound, tubing fluidly communicable with the wound space, and a canister fluidly communicable with the tubing. The canister, the tubing, and the dressing define a sealed space that includes the wound space. The wound therapy system also includes a therapy unit coupled to the canister. The therapy unit includes a sensor configured to measure a pressure in the sealed space, a valve positioned between the sealed space and a surrounding environment and controllable between an open position and a closed position, and a control circuit. The control circuit is configured to control the valve to alternate between the open position and the closed position to allow airflow through the valve, receive measurements from the sensor, and determine a volume of the wound space based on the measurements.

Abstract: Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of vadadustat.

Abstract: Tissue interfaces, kits, and methods for treating an abdominal cavity. A tissue interface for use in an abdominal cavity includes a first contact layer, a second contact layer, a spacer layer, and a plurality of location tags. The first contact layer comprises a first plurality of perforations. The second contact layer comprises a second plurality of perforations. The spacer layer is disposed between the first contact layer and the second contact layer. The plurality of location tags are configured to be located by an identifier tool and to be positioned in a plurality of treatment areas within the abdominal cavity.

Abstract: A fiducial is generated on an internal anatomical structure of the eye of a patient with a surgical laser. A toric artificial intraocular lens (IOL) is positioned so that a marker of the toric IOL is in a predetermined positional relationship relative to the fiducial. This positioning aligns the toric IOL with the astigmatic or other axis of the eye. The toric IOL is then implanted in the eye of the patient with high accuracy.

Abstract: A method implemented in an ophthalmic laser system to perform iris registration based on two iris images taken with the patient at upright and supine positions, respectively. For each iris image, the iris region is transformed into a rectangular rubbersheet, with the radial and angular coordinates of the iris image respectively mapped to vertical and horizontal coordinates of the rubbersheet. A horizontal one-dimensional log-Gabor transform is applied to the rubbersheet line-by-line. The transformed rubbersheet is binarized line-by-line. The two binary rubbersheets are compared at a series of relative horizontal shifts to determine the horizontal shift value that produces the lowest Hamming distance between the two binary rubbersheets, and the cyclotorsion rotation of the eye between the upright and supine positions is calculated accordingly.

Abstract: Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.

Abstract: A system is disclosed. The system may include a storage device and a processor. The processor may send a write request to the storage device. The write request may include a data to be written and a reclaim unit identifier identifying how the data is to be organized on the storage device. The processor may also send a message to the storage device regarding management of garbage collection of a reclaim unit identified by the reclaim unit identifier.

Abstract: A method of improving effluent brine quality, the method (i) providing a mud wash solvent comprising a hydrocarbon having a specific gravity less than that of a desalter brine to be treated; and (ii) adding the mud wash solvent to a mud wash stream of a desalter system to provide a treated effluent brine.

Abstract: A fiducial is generated on an internal anatomical structure of the eye of a patient with a surgical laser. A toric artificial intraocular lens (IOL) is positioned so that a marker of the toric IOL is in a predetermined positional relationship relative to the fiducial. This positioning aligns the toric IOL with the astigmatic or other axis of the eye. The toric IOL is then implanted in the eye of the patient with high accuracy.

Abstract: A cuff for measuring blood flow through arteries of a limb may include an interior surface, a bladder, and a blood flow sensor. The interior surface of the cuff is configured to be secured around the limb. The bladder is configured to be fluidly coupled to a source of positive pressure. The bladder is further be adapted to inflate in response to application of a positive pressure and restrict blood flow through the arteries of the limb when inflated. The blood flow sensor is coupled to the interior surface and disposed between the interior surface and the limb. The blood flow sensor is configured to measure blood flow through the arteries of the limb.

Abstract: A laser system is calibrated with a tomography system capable of measuring locations of structure within an optically transmissive material such as a tissue of an eye. Alternatively or in combination, the tomography system can be used to track the location of the eye and adjust the treatment in response to one or more of the location or an orientation of the eye. In many embodiments, in situ calibration and tracking of an optically transmissive tissue structure such as an eye can be provided. The optically transmissive material may comprise one or more optically transmissive structures of the eye, or a non-ocular optically transmissive material such as a calibration gel in a container or an optically transmissive material of a machined part.