Abstract: Example solutions for processing LLM prompts include creating a first large language model (LLM) prompt based on an input LLM prompt. The first LLM prompt represents a first step toward generating a solution to the input LLM prompt. The first LLM prompt is submitted to an LLM as a first sub-query, thereby resulting in the generation of a first LLM output. A second LLM prompt is generated based on the input LLM prompt. The second LLM prompt represents a second step toward generating the solution. The second LLM prompt includes the first LLM output. The second LLM prompt is submitted to the LLM as a second sub-query, thereby resulting in the generation of a second LLM output. The second LLM output represents the solution to the input LLM prompt in response to the input LLM prompt.

Abstract: A method implemented in an ophthalmic laser system to perform iris registration based on two iris images taken with the patient at upright and supine positions, respectively. For each iris image, the iris region is transformed into a rectangular rubbersheet, with the radial and angular coordinates of the iris image respectively mapped to vertical and horizontal coordinates of the rubbersheet. A horizontal one-dimensional log-Gabor transform is applied to the rubbersheet line-by-line. The transformed rubbersheet is binarized line-by-line. The two binary rubbersheets are compared at a series of relative horizontal shifts to determine the horizontal shift value that produces the lowest Hamming distance between the two binary rubbersheets, and the cyclotorsion rotation of the eye between the upright and supine positions is calculated accordingly.

Abstract: Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.

Abstract: The technology described in this document can be embodied in a computer-implemented method that includes receiving, at a processing system, a first signal including an output of a speaker device and an additional audio signal. The method also includes determining, by the processing system, based at least in part on a model trained to identify the output of the speaker device, that the additional audio signal corresponds to an utterance of a user. The method further includes initiating a reduction in an audio output level of the speaker device based on determining that the additional audio signal corresponds to the utterance of the user.

Abstract: A method of improving effluent brine quality, the method (i) providing a mud wash solvent comprising a hydrocarbon having a specific gravity less than that of a desalter brine to be treated; and (ii) adding the mud wash solvent to a mud wash stream of a desalter system to provide a treated effluent brine.

Abstract: A system is disclosed. The system may include a storage device and a processor. The processor may send a write request to the storage device. The write request may include a data to be written and a reclaim unit identifier identifying how the data is to be organized on the storage device. The processor may also send a message to the storage device regarding management of garbage collection of a reclaim unit identified by the reclaim unit identifier.

Abstract: Example solutions for real-world evidence generation using artificial intelligence models and performing trial simulations include: training a large language model (LLM) to receive medical documents that include medical text associated with a patient output predicted values for medical attributes of the patient based on the medical text; performing attribute extraction from structured medical documents, including extracting values for a first plurality of attributes associated with the plurality of patients; performing attribute extraction from a plurality of unstructured medical documents of the plurality of patients using the LLM, including extracting predicted values for a second plurality of attributes associated with the plurality of patients; and performing a survival model simulation that computes estimations of hazard ratio (HR) between cases and controls using real-world data of the plurality of patients extracted in the first attribute extraction and second attribute extraction.

Abstract: A fiducial is generated on an internal anatomical structure of the eye of a patient with a surgical laser. A toric artificial intraocular lens (IOL) is positioned so that a marker of the toric IOL is in a predetermined positional relationship relative to the fiducial. This positioning aligns the toric IOL with the astigmatic or other axis of the eye. The toric IOL is then implanted in the eye of the patient with high accuracy.

Abstract: A cuff for measuring blood flow through arteries of a limb may include an interior surface, a bladder, and a blood flow sensor. The interior surface of the cuff is configured to be secured around the limb. The bladder is configured to be fluidly coupled to a source of positive pressure. The bladder is further be adapted to inflate in response to application of a positive pressure and restrict blood flow through the arteries of the limb when inflated. The blood flow sensor is coupled to the interior surface and disposed between the interior surface and the limb. The blood flow sensor is configured to measure blood flow through the arteries of the limb.

Abstract: A laser system is calibrated with a tomography system capable of measuring locations of structure within an optically transmissive material such as a tissue of an eye. Alternatively or in combination, the tomography system can be used to track the location of the eye and adjust the treatment in response to one or more of the location or an orientation of the eye. In many embodiments, in situ calibration and tracking of an optically transmissive tissue structure such as an eye can be provided. The optically transmissive material may comprise one or more optically transmissive structures of the eye, or a non-ocular optically transmissive material such as a calibration gel in a container or an optically transmissive material of a machined part.

Abstract: A method of improving effluent brine quality, the method (i) providing a mud wash solvent comprising a hydrocarbon having a specific gravity less than that of a desalter brine to be treated; and (ii) adding the mud wash solvent to a mud wash stream of a desalter system to provide a treated effluent brine.

Abstract: A device for the detection of gamma rays to be used primarily in a PET scanner is based on a scintillator heterostructure combining the high stopping power of scintillators commonly used in PET scanners (such as L(Y)SO, BGO, etc.) and fast scintillators based on polymers loaded with fast emitting dyes or nanocrystals, or thin layers of nanocrystals or multiple quantum well structures. While the metascintillator block is read out in the monolithic or semi-monolithic arrangement, the fast scintillator is segmented so that it is read out by less photodetectors. The particular arrangement of this detector module allows combining all the important features of a high-performance Time-of-Flight PET (TOFPET) detector module, i.e. a high photoelectric detection efficiency for the gamma rays, a precise 3D information (including the depth of interaction DOI) of the gamma ray conversion in the module, good energy resolution and superior timing resolution.

Abstract: A negative pressure dressing includes a first foam section, a second foam section, and a longitudinal seam joining the first foam section to the second foam section. The longitudinal seam has a higher rigidity than the first foam section and the second foam section.

Abstract: Linear peptides that inhibit the phosphorylation mediated by the enzyme Casein Kinase 2 (CK2), which have an amino acid sequence selected from the group consisting of the sequences identified as SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 50, and SEQ ID NO: 57-SEQ ID NO: 62, as well as polypeptides comprising said peptides and an intracellular penetrating peptide. A pharmaceutical composition comprising at least one of these linear peptides or polypeptides and a pharmaceutically acceptable carrier. The invention also discloses the use of said peptides or polypeptides for the manufacture of a drug, and a method of treating solid or liquid tumors where said drug is administered.

Abstract: The invention is relate with a pharmaceutical composition comprising peptide type APL called identified as SEQ ID No. 1, sodium acetate buffer at pH 3.9-4.7; and at least one stabilizing sugar selected from sucrose or trehalose. This pharmaceutical composition is useful for manufacture of a medicament for treating inflammatory diseases related to an increase of neutrophils or citrullination of proteins. These inflammatory diseases include rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), Alzheimer's disease, and hepatic and pulmonary fibrosis. The invention also discloses a method for the treatment of these diseases, through effective therapeutic administration of the pharmaceutical composition of APL-type peptide.

Abstract: A tissue interface, suitable for use in an abdominal cavity, may comprise a liquid-impermeable layer having manifolding bubbles on at least a first surface. In some embodiments, a pattern of break-lines, without bubbles, may separate the plurality of bubbles into zones. For example, each break-line may be wider than the gap spacing between bubbles within adjacent zones on either side of the break-line. In some embodiments, the configuration of the pattern of break-lines may impact fluid flow rate across the liquid-impermeable layer during negative-pressure therapy. Users may be able to select a tissue interface with a break-line pattern corresponding to a desired fluid flow rate.

Abstract: The present invention relates to a quantum computer-implemented method for solving a partial differential equation for a function f which maps at least a subspace of a k-dimensional real space Rk into at least a subspace of an m-dimensional real space Rm, f: Rk?Rm, f: (t, X)·?f(t, X), wherein t e R, X e Rk-1. Furthermore, the present invention is related to an apparatus for solving such a partial differential equation using a quantum computer.

Abstract: A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.

Abstract: A method for decentralized management of edge computing nodes, where the user equipment assumes direct control of the edge nodes through an integrated edge manager module, which has means for seamlessly onboarding edge applications onto edge computing nodes, eliminating the need for a central management entity in the network. The user equipment further includes a context storage module to store applications and support the migration of their context into another edge computing node. The edge manager module of the user equipment can request the application context data of edge applications running in an edge computing node, store context data, onboard the edge application configurations in other edge computing nodes, instantiate the edge applications, and configure the application context data into the destination edge computing node, even in scenarios without direct connectivity between edge nodes.

Abstract: Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.