Abstract: Disclosed are methods of treating various disorders with anti-IL-4R? antibodies and fragments thereof.

Abstract: Systems, methods, and computer products can predict rates of hypoglycemia in patients. One of the methods includes receiving data representing medical records of a patient, the patient having been diagnosed with diabetes mellitus. The method includes determine an predicted rate of hypoglycemic events using a machine learning system, the machine being trained using data representing the medical records of a plurality of patients and the corresponding rate of hypoglycemic events for the respective patients. The methods also includes producing the predicted rate for the patient.

Abstract: Data processing systems for repurposing a drug can include a computer-readable memory including computer-executable instructions; and at least one processor configured to execute executable logic including the computer-executable instructions and at least one machine learning model to perform one or more operations. The one or more operations can include receiving data representing medical records of a plurality of patients; selecting a set of patients; determining a plurality of patient characteristics of the set of patients; grouping, in accordance with the plurality of patient characteristics, the set of patients to generate a plurality of distinct groups, each of the distinct groups including at least one patient of the set of patients; selecting, based on one or more group selection criteria, a set of distinct groups of the plurality of distinct groups; and identifying one or more relevant patient characteristics by analyzing each distinct group of the set of distinct groups.

Abstract: There is described a nonwoven material comprising a multilayered stack, the multilayered stack comprising discrete interconnected layers, each of the layers, which may be the same or different, comprising a composite fibre of from about 80 to 100% w/w leaf or stem fibre and from about 1 to 20% w/w of a polymer, wherein the polymer is fusible at a temperature of about 180° C. or less. There is also described a novel method of enzyme degumming leaf and/or stem fibres.

Abstract: A system for the physical-mechanical recovery and refining of non-ferrous metals from electronic scrap, with means for the separation of the interest metals from the polymeric and resin support frames, which does not require the addition of solvents or temperature rise, for the disintegration and separation of materials, so that no toxic waste is produced for the environment.

Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Abstract: A manufacturing and assembly method of parts of an aircraft comprising the following several steps. Providing a first aircraft part comprising a receptor surface on which a coupling surface of a second aircraft part is to be assembled. Providing a model of the first and the second aircraft parts in their assembled position, the model of the second aircraft part comprising machining allowances in its coupling surface. Digitalizing the receptor surface of the first aircraft part. Positioning the digitalization in the computer model in the assembled position such that the digitalization of the receptor surface intersects the coupling surface of the second aircraft part. Obtaining a model of the second part in which the coupling surface fits the digitalized receptor surface. Mechanizing the second aircraft part.

Abstract: Disclosed is a method and system to carry out the method comprising the steps: analyzing biological samples of a patient to obtain measurement values and according to a test order; a laboratory middleware receiving the measurement values; providing a virtual analyzer comprising a workflow engine and an algorithm calculator distinct from the laboratory middleware; the workflow engine receiving input data comprising the measurement values and second input data comprising patient data from the laboratory middleware; the algorithm calculator processing the input data and using the clinical algorithm as instructed by the workflow engine and transmitting interpretation support data to the workflow engine; and the laboratory middleware augmenting the measurement values and with the interpretation support data received from the virtual analyzer.

Abstract: A retaining device, a retaining system between a female part and a male part, and a female part and male part to assure retention between a wear element or tooth and an adaptor element or tooth bar used in excavators and the like. The female part, which can be a wear element or tooth, or an adaptor element or tooth bar, has, auto-fixed thereto, a retaining device which participates in the coupling with a pin of the female part with a male part, and prevents the pin from coming out of its blocking position, maintaining the fixing between the two parts, i.e., male part and female part. The coupling between both parts is detachable, allows removing the pin from the coupling and replacing the female part or male part together with the retaining device. The retaining device is formed by one or more attached tightening elements.

Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Abstract: The present invention provides a steel sheet or part suitable for enamelling. The steel sheet or part is coated with a coating including polymer in which particles of non-oxide ceramic are homogeneously dispersed. A process for producing an enamelled steel sheet or part which has a reduced firing temperature and reduced time compared with conventional firing temperatures and times is also provided. An enamelled steel sheet or part are also provided.

Abstract: An antenna assembly for aircraft including: a vertical tail of the aircraft including a front spar, a leading edge skin covering a leading portion of the front spar and a rib extended between the front spar and the leading edge skin; an antenna radiating element extending a length of the vertical tail and positioned between the leading edge skin and the front spar; a first metallic element included with or attached to the front spar; a second metallic element, wherein the second metallical element is electrically coupled to the antenna radiating element and to the first metallic element; an antenna coupler in electrical electrically connected to the antenna radiating element and the first metallic element, and wherein a closed looped electrical circuit is formed by the antenna radiating element, the first metallic element, the second metallic element and the antenna coupler.

Abstract: In an approach for sharing memory bandwidth in one or more processors, a processor receives a first set of monitored usage information for one or more processors executing one or more threads. A processor calculates impact of hardware data prefetching for each thread of the one or more threads, based on the first set of monitored usage information. A processor adjusts prefetch settings for the one or more threads, based on the calculated impact of hardware data prefetching for each thread of the one or more threads.

Abstract: The invention relates to a retaining device, a retaining system between a female part and a male part, and a female part and male part to assure the retention between a wear element or tooth and an adaptor element or tooth bar used in excavators and the like. The female part, which can be a wear clement or tooth, or an adaptor element or tooth bar, comprises, auto-fixed thereto, a retaining device which participates in the coupling with a pin of the female part with a male part, and prevents the pin from coming out of its blocking position, maintaining the fixing between the two parts, i.e., male part and female part. The coupling between both parts is detachable, allows removing the pin from the coupling and replacing the female part or male part together with the retaining device.

Abstract: The invention relates to a retaining device, a retaining system between a female part and a male part, and a female part and male part to assure the retention between a wear element or tooth and an adaptor element or tooth bar used in excavators and the like. The female part, which can be a wear element or tooth, or an adaptor element or tooth bar, comprises, auto-fixed thereto, a retaining device which participates in the coupling with a pin of the female part with a male part, and prevents the pin from coming out of its blocking position, maintaining the fixing between the two parts, i.e., male part and female part. The coupling between both parts is detachable, allows removing the pin from the coupling and replacing the female part or male part together with the retaining device.

Abstract: Device for detachable fastening of two mechanical components between which a channel or housing is defined, including a peg, with at least two grooves on opposite faces, and a band accommodated in the grooves, fastened by pinching at the lower part of the peg and with a flexible portion that has the upper end thereof bent in order to retain the peg/band assembly in a transverse grove of the channel The invention applies in particular to the fastening of a tooth in a tooth holder of the scoop of an excavating machine or the like.

Abstract: An antenna assembly for aircraft including: a vertical tail of the aircraft including a front spar, a leading edge skin covering a leading portion of the front spar and a rib extended between the front spar and the leading edge skin; an antenna radiating element extending a length of the vertical tail and positioned between the leading edge skin and the front spar; a first metallic element included with or attached to the front spar; a second metallic element, wherein the second metallical element is electrically coupled to the antenna radiating element and to the first metallic element; an antenna coupler in electrical electricaly connected to the antenna radiating element and the first metallic element, and wherein a closed looped electrical circuit is formed by the antenna radiating element, the first metallic element, the second metallic element and the antenna coupler.

Abstract: In an approach for sharing memory bandwidth in one or more processors, a processor receives a first set of monitored usage information for one or more processors executing one or more threads. A processor calculates impact of hardware data prefetching for each thread of the one or more threads, based on the first set of monitored usage information. A processor adjusts prefetch settings for the one or more threads, based on the calculated impact of hardware data prefetching for each thread of the one or more threads.

Abstract: A clothing accessory that protects from the cold, comprising a sleeve-shaped body having a top opening and a bottom opening, the top opening of the body at least comprising retaining means capable of fixing said body to both the neck and the lower portion of the face of the user, wherein fastening means are arranged in a rear portion of the top opening of the sleeve-shaped body, it being possible to firmly couple said fastening means to the ears and the back portion of the head of the user to hold the accessory in place.

Abstract: Analytical immunosensor device and method for obtaining thereof based on sequential deposition of self-assembled monolayers of polymers and affinity elements and their uses for the detection and quantitation of any analyte or target antigen in a liquid sample, allowing to perform the analysis by quasi-reagentless or reagentless displacement assay, and minimizing nonspecific adsorption and thus decreasing the detection limit. The device is arranged from a sensor surface covered with polymer monolayers (redox or non-redox) on top of which submonolayers of affinity elements are deposited and then, to let the affinity reaction to take place with the antigen, pseudo-antigen or the hapten labelled with a protein, preferably an enzyme (redox or non-redox), or with a nanoparticle enabling the method of the invention to develop “ad hoc” immunosensors, with a signal transduction by electrochemical, optical and/or piezoelectric means.