Abstract: A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(?GST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the ?GST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia.

Abstract: A self-contained portable head worn device and methods to stimulate a portion of the brain of a wearer are presented. A first electrode is held by the head worn device against the scalp of the wearer in a first location and a second electrode is held against the scalp of the wearer in a second location. A pulse generator generates a first electric signal received by the first electrode and a second electric signal received by the second electrode. A power source is connected to the pulse generator.

Abstract: A self-contained portable head worn device and methods to stimulate a portion of the brain of a wearer are presented. A first electrode is held by the head worn device against the scalp of the wearer in a first location and a second electrode is held against the scalp of the wearer in a second location. A pulse generator generates a first electric signal received by the first electrode and a second electric signal received by the second electrode. A power source is connected to the pulse generator.

Abstract: Embodiments of the invention include a method for categorizing and displaying design rule errors. The method may include receiving, from a design rule checker, more than one violation of a design rule within a design layout. The method may also include determining distinct categories of the design rule violations by comparing parameters associated with the design rule violations.

Abstract: Embodiments of the invention include a method for categorizing and displaying design rule errors. The method may include receiving, from a design rule checker, more than one violation of a design rule within a design layout. The method may also include determining distinct categories of the design rule violations by comparing parameters associated with the design rule violations.

Abstract: A method for the early identification and prediction of abrupt reduction in kidney function in a patient undergoing cardiothoracic (CT) surgery, including Cardio-Pulmonary Bypass (CPB), comprises contacting a urine sample from the patient with a capture molecule for a biomarker, especially ?GST specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of an abrupt reduction in kidney function, the biomarker being detectable as early as intraoperatively or in the recovery stage post CT surgery, for example prior to transfer of the patient to the Intensive Care Unit (ICU), allowing for immediate corrective medical intervention. The method can be used to detect Acute Kidney Injury (AKI) and a requirement for Renal Replacement Therapy (RRT) namely dialysis, earlier than two hours post CT surgery and as early as zero hours post or during CT surgery or CPB.

Abstract: A system for transferring spinal cord signals comprises a superior electrode and an inferior electrode. The superior electrode interfaces with a first portion of a spinal cord of a human body; and the inferior electrode interfaces with a second portion of the spinal cord. The superior electrode has at least one superior contact for receiving signals from the first portion of the spinal cord to transmit to the inferior electrode; and the inferior electrode has at least one inferior contact for transmitting signals received from the superior electrode to the second portion of the spinal cord.

Abstract: A system for transferring spinal cord signals comprises a superior electrode and an inferior electrode. The superior electrode interfaces with a first portion of a spinal cord of a human body; and the inferior electrode interfaces with a second portion of the spinal cord. The superior electrode has at least one superior contact for receiving signals from the first portion of the spinal cord to transmit to the inferior electrode; and the inferior electrode has at least one inferior contact for transmitting signals received from the superior electrode to the second portion of the spinal cord.

Abstract: A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(?GST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the ?GST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia.

Abstract: In a method of routing a wire to a shape in an integrated circuit for minimizing undesirable jog creation during a masking process, a plurality of possible placements of the wire relative to a selected edge of the shape resulting in the wire being connected to the shape are determined. A cost is assigned to each placement, the cost indicating an amount of jog that would be created in the masking process corresponding to the placement, wherein a greater cost indicates that a greater jog would be created in the masking process than would be created by a placement assigned a lesser cost. A placement having a lowest cost of the plurality of possible placements is selected.

Abstract: A method for the early identification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic (CT) surgery, including Cardio-Pulmonary Bypass (CPB), comprises contacting a urine sample from the patient with a capture molecule for a biomarker, especially ?GST, specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of an abrupt reduction in kidney function, the biomarker being detectable as early as intraoperatively or in the recovery stage post CT surgery, for example prior to transfer of the patient to the Intensive Care Unit (ICU), allowing for immediate corrective medical intervention. The method can be used to detect Acute Kidney Injury (AKI) and a requirement for Renal Replacement Therapy (RRT) namely dialysis, earlier than two hours post CT surgery and as early as zero hours post or during CT surgery or CPB.

Abstract: A method for the early identification and prediction of elevated blood creatinine levels resulting from a reduction in kidney function in a subject, comprises contacting a urine sample from the subject with a capture molecule for a biomarker specific for the distal region of the renal tubule and which biomarker is released from said region when there is damage to said region indicative and predictive of elevated blood creatinine levels resulting from a reduction in kidney function. The method can be used to detect Acute Kidney Injury (AKI) caused by many conditions or diseases or through the administration of drugs. The method can indicate and/or predict a reduction in kidney function significantly earlier than the current standard creatinine test. Methods for predicting a need for renal replacement therapy (RRT) are also disclosed.

Abstract: A technique for verifying error detection of a design rule checking runset includes assigning first shapes for a first layer of an integrated circuit design to a first cell and assigning second shapes for a second layer of the integrated circuit design to a second cell. Design rule checking is then performed on the first and second cells. Whether the design rule checking runset is functioning properly is then determined based on whether an error is detected in the design rule checking of the first and second cells.

Abstract: In a method of routing a wire to a shape in an integrated circuit for minimizing undesirable jog creation during a masking process, a plurality of possible placements of the wire relative to a selected edge of the shape resulting in the wire being connected to the shape are determined. A cost is assigned to each placement, the cost indicating an amount of jog that would be created in the masking process corresponding to the placement, wherein a greater cost indicates that a greater jog would be created in the masking process than would be created by a placement assigned a lesser cost. A placement having a lowest cost of the plurality of possible placements is selected.

Abstract: A self-contained, integrated micro-cube-sized inertial measurement unit is provided wherein accuracy is achieved through the use of specifically oriented sensors, the orientation serving to substantially cancel noise and other first-order effects, and the use of a noise-reducing algorithm such as wavelet cascade denoising and an error correcting algorithm such as a Kalman filter embedded in a digital signal processor device. In a particular embodiment, a pair of three sets of angle rate sensors are orientable triaxially in opposite directions, wherein each set is mounted on a different sector of a base orientable normal to the other two and comprising N gyroscopes oriented at 360/N-degree increments, where N?2. At least one accelerometer is included to provide triaxial data. Signals are output from the angle rate sensors and accelerometer for calculating a change in attitude, position, angular rate, acceleration, and/or velocity of the unit.

Abstract: A computer program product stored on machine readable media includes machine executable instructions for displaying a layout of a circuit design, the product including instructions for: over a plurality of layers within a design, identifying at least one of a derived level and a device defined within the plurality; and displaying the at least one derived level and device to a user.

Abstract: A system for transferring spinal cord signals comprises a superior electrode and an inferior electrode. The superior electrode interfaces with a first portion of a spinal cord of a human body; and the inferior electrode interfaces with a second portion of the spinal cord. The superior electrode has at least one superior contact for receiving signals from the first portion of the spinal cord to transmit to the inferior electrode; and the inferior electrode has at least one inferior contact for transmitting signals received from the superior electrode to the second portion of the spinal cord.

Abstract: A fund-raising method and system relating to the planning and administration of fund-raising events such as live auctions, on-line sales, and on-line auction events. In a preferred aspect, a centralized Web site accessible by network users is provided and maintained for hosting on-line fund-raising auctions of goods or services in the name of fund-raising entities, where the goods or services are not owned or provided by the fund-raising entities, and preferably are provided or owned by the host of the fundraising event or host of the Web site. The goods or services are auctioned to users visiting the Web site, payment from a user successfully bidding on a good or service for auction is received and a portion of the payment preferably is allocated to the fund-raising entity. A rebate may be provided to the fund-raising organization proportional to a total amount of revenue generated during a fund-raising event, the rebate may be applicable to the cost of future fund-raising events.

Abstract: A digital multiplier has recoders for recoding the multiplier bits to form selection bits which are applied to selectors for selecting forms of the multiplicand, either the multiplicand itself or multiples of the multiplicand, the selected forms being applied to adders which produce partial products, the adders being interconnected to produce the product. Special product generators simultaneously generate multiples of the multiplicand which are applied to the selectors.