Abstract: A sleeve for protecting a lockdown screw of a wellhead assembly can include a body having an inner surface and an outer surface, wherein the body has a concave curvature, where the body is configured to be disposed within an upper portion of a recess of a component of the wellhead assembly inside of which the lockdown screw is disposed, where the concave curvature of the body is configured to match that of an inner wall of the component, and where the outer surface is configured to isolate the lockdown screw from an environment in a cavity partially formed by the inner surface when the body is disposed in the upper portion of the recess.

Abstract: Sensors may be located remotely from a rig of a well. The sensors may operate independently of the rig, and generate remote sensor information that characterizes operating characteristics of the well independent of the rig. The operation of the well may be analyzed based on the remote sensor information.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit PI3K?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by PI3K?.

Abstract: Disclosed are sweetened consumables and methods of forming said sweetened consumables that comprise certain sweeteners and at least one sweetness enhancer in a concentration near its sweetness detection threshold. The sweeteners include sucrose, fructose, glucose, high fructose corn syrup, corn syrup, xylose, arabinose, rhamnose, erythritol, xylitol, mannitol, sorbitol, inositol, acesulfame potassium, aspartame, neotame, sucralose, saccharine, or combinations thereof. The sweetness enhancer is selected from naringin dihydrochalcone, mogroside V, swingle extract, rubusoside, rubus extract, rebaudioside, and stevioside.

Abstract: The use of compounds according to formula (I) and with X, Y?—NH— or —O—, wherein at least X or Y is —NH—, in the form of any one of its stereoisomers or a mixture thereof, wherein is indicating a carbon-carbon single or double bond, and wherein one carbon-carbon double bond is present either at C2 or C3, the wavy bond is indicating an unspecified configuration of the adjacent double bond, as umami tastant.

Abstract: A system for fracturing multiple wellbores on a multi-well pad can include a missile that receives high-pressure fracturing fluid from a plurality of pump truck. The system can also include a main manifold that receives the high-pressure fracturing fluid from the missile, where the main manifold includes multiple valves and multiple output channels, where each of the valves are operated between an open position and a closed position. The system can further include multiple wellbores including a first wellbore, a second wellbore, and a third wellbore, where the wellbores are connected to the output channels of the main manifold. The valves of the main manifold can be operated to enable simultaneous flow of the high-pressure fracturing fluid to the first wellbore, the second wellbore, and the third wellbore so that the first wellbore, the second wellbore, and the third wellbore are fractured simultaneously.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: An offline casing string rotation system can include a ring gear configured to be coupled to a rotatable mandrel casing hanger, where the rotatable mandrel casing hanger is part of a wellhead assembly and is coupled to a top end of a casing string. The offline casing string rotation system can also include a gear driving assembly moveably coupled to the ring gear, wherein the gear driving assembly, when enabled, causes the gear to rotate the rotatable mandrel casing hanger.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Provided herein are improved processes for preparing aminopyrimidine compounds of Formula (I). The disclosed processes advantageously proceed through a ?-diketoester intermediate of Formula (A) and avoid the direct linking of a pyrimidine and phenyl moieties. The disclosed methods significantly increase yield of the desired compounds and simplifies the synthetic route.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: Dimensions of a tool moving in/out of a well may be measured during well operations. The measured dimensions of the tool may be used to analyze the well operations. Analysis of well operations may include identification of types of well operations being performed at the well, monitoring of the well operations, benchmarking of the well operations, identification of tools being used in the well operations, and/or other analysis of the well operations.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.